J C Bermak,Q Y Zhou
J C Bermak
Intracellular accessory proteins can be critical for G protein-coupled receptor (GPCR) biogenesis, including aspects of GPCR trafficking. Recent discoveries include the identification of multiple membrane-associated proteins that dictate no...
Z Wang
Z Wang
Tolerance to some degree of unrepaired DNA damage is crucial for cell survival-more specifically, for the sustained functionality of the DNA replication machinery-in the presence of adverse (genotoxic) conditions. At least two mechanisms en...
Promiscuous ligands and attractive cavities: how do the inhaled anesthetics work? [0.03%]
共辄配体与吸引腔室：吸入麻醉剂的作用机理是什么？
R G Eckenhoff
R G Eckenhoff
The inhaled anesthetics were officially introduced to American medicine more than 160 years ago and rank among the most important medical advances in our time. These drugs are used to render patients insensible over twenty million times eac...
R Ruffolo
R Ruffolo
By his own admission, Robert R. Ruffolo, Head of Research and Development at Wyeth-Ayerst, is a bit of a nerd. Opting to spend seven nights per week with his textbooks at the expense of all else, he earned his pharmacy degree summa cum laud...
J Guillemin
J Guillemin
L G Miller
L G Miller
Expression array technology in the diagnosis and treatment of breast cancer [0.03%]
基因表达谱技术在乳腺癌诊治中的应用
Stefanie S Jeffrey,Michael J Fero,Anne-Lise Børresen-Dale et al.
Stefanie S Jeffrey et al.
The most common group of cancers among American women involves malignancies of the breast. Breast cancer is a complex disease, involving several different types of tissues and specific cells with various functions, that is categorized into ...
The GoLoco motif: heralding a new tango between G protein signaling and cell division [0.03%]
新的韵律：G蛋白信号转导与细胞分裂之间的戈洛科模体
Randall J Kimple,Francis S Willard,David P Siderovski
Randall J Kimple
The Galpha and Gbetagamma components of heterotrimeric G proteins, typically associated with cell-surface receptor signaling, also partake in the macromolecular interactions that underlie cell polarity and cell division. Proteins with Galph...
LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing [0.03%]
脂质稳态的奢华：核激素受体、转录调控和胆固醇感应的统一性
Yuan Zhang,David J Mangelsdorf
Yuan Zhang
Cholesterol homeostasis is maintained by a regulatory network that controls both the acquisition and elimination of cholesterol. Recent studies have elucidated a mechanism by which cholesterol metabolism is transcriptionally regulated by se...