The "heartbreak" of older age [0.03%]
老年的心碎之痛
Edward G Lakatta,Steven J Sollott
Edward G Lakatta
Philip L Cohen
Philip L Cohen
Cytokines in heart failure: potential interactions with angiotensin II and leptin [0.03%]
心力衰竭中的细胞因子与血管紧张素Ⅱ及脂素的潜在相互作用
Bethany J Holycross,M Judith Radin
Bethany J Holycross
Rene Vandenboom,Joseph M Metzger
Rene Vandenboom
On average, the human heart beats 100,000 times a day and it is in a person's best interest to have the heart move blood as efficiently as possible. For example, imagine a wet rag: squeezing the rag in your fist does not remove as much wate...
In the service of pharmacology [0.03%]
药理学服务
Paul Vanhoutte
Paul Vanhoutte
Hiroshi Hosoda,Masayasu Kojima,Kenji Kangawa
Hiroshi Hosoda
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach and is released in response to acute and chronic changes in nutritional state. In addition to having a powerful effect on ...
Ibrahim Halil Kavakli,Aziz Sancar
Ibrahim Halil Kavakli
Circadian rhythms are the endogenous oscillations, occurring with a periodicity of approximately twenty-four hours, in the biochemical and behavioral functions of organisms. In mammals, the phase and period of the rhythm are synchronized to...
Sheila A Stewart
Sheila A Stewart
Normally, cell division leads to shortening of telomeres, the nucleoprotein complexes located at the ends of linear chromosomes. When telomeres reach a critically short length, cells cease to divide. However, immortal tumor cells display st...
François Mach
François Mach
The family of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitors, collectively known as statins, is used clinically to reduce cholesterol levels in patients. Recent reports suggest that not only would statin therapy be beneficial fo...
Modulating modulation: crosstalk between regulatory pathways of presynaptic calcium channels [0.03%]
调控的调节：前突触钙通道调控途径之间的串扰
Gerald W Zamponi,Terrance P Snutch
Gerald W Zamponi
The activity of some voltage-gated calcium channels (VGCCs) can be inhibited by specific G protein beta subunits. Conversely, in the case of N-type VGCCs, protein kinase C can relieve Gbeta-dependent inhibition by phosphorylating at least o...