Richard Weinshilboum
Richard Weinshilboum
Richard Weinshilboum has a no-nonsense attitude about pharmacogenetics. He is enthusiastic about the practicalities and ramifications of the field's solid accomplishments, but he carefully measures statements that might feed the hype that i...
Central neural mechanisms that interrelate sensory and affective dimensions of pain [0.03%]
与痛觉感觉和情感维度相关的中枢神经机制
Donald D Price
Donald D Price
The perception of pain is highly complex, and requires neural integration from a variety of routes. Spinal pathways to the amygdala, hypothalamus, reticular formation, medial thalamic nuclei, and limbic cortical structures transmit informat...
Edwin J Weeber,Jonathan M Levenson,J David Sweatt
Edwin J Weeber
Our understanding of the molecular underpinnings of human cognition has been greatly aided by the convergent synergy of clinical, genetic, and signaling research. By identifying the mutated genes that give rise to syndromes of mental retard...
K R Bales,J C Dodart,R B DeMattos et al.
K R Bales et al.
Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (ap...
Guojun Cheng,Otabek Imamov,Yoko Omoto et al.
Guojun Cheng et al.
The presence or absence of estrogen receptor (ER) expression in tumor cells affects prognosis and guides treatment choices. Kumar et al. suggest that a shortened form of the metastatic tumor antigen 1 (MTA1s) acts to sequester the estrogen ...
Determining the destiny of NF-kappa B after TCR ligation: it's CARMA1 [0.03%]
CARMA1决定TCR聚集后NF-κB的命运
Stephen C Bunnell
Stephen C Bunnell
In T lymphocytes, the "novel" protein kinase C theta (PKC theta) isoform and the transcription factor nuclear factor-kappaB (NF-kappaB) are required for cell proliferation and the production of cytokines in response to T cell activation; ho...
Phospholipase C-gamma1: a phospholipase and guanine nucleotide exchange factor [0.03%]
磷脂酶C-gamma1：一种磷脂酶和鸟苷核苷酸交换因子
Zhixiang Wang,Michael F Moran
Zhixiang Wang
Although phospholipase C-gamma (PLC-gamma) participates in cellular mitogenesis, evidence indicates that the catalytic activity of PLC-gamma (to hydrolyze certain phosphoinositides) is nonessential to the process. So how is it that PLC-gamm...
Research as an art form [0.03%]
作为艺术形式的研究
Sol Synder
Sol Synder
Nathan Greenslit
Nathan Greenslit
William T Gerthoffer,Cherie A Singer
William T Gerthoffer