The missing link(er): a return to symmetry in antigen receptor signaling? [0.03%]
缺失的链路（符）：抗原受体信号传导回归对称？
Ronald L Wange
Ronald L Wange
B lymphocytes and T lymphocytes utilize several proteins with common functions to transduce signals from their respective receptors. However, at the hierarchial signalling level of SLP-76 [Src homology 2(SH2) domain-containing leukocyte pro...
Jeremy Veenstra-VanderWeele,Edwin H Cook Jr
Jeremy Veenstra-VanderWeele
A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1(-/-)mice were found to express normal amounts of serotonin in brain, but not in the periphery. Addi...
Mordecai P Blaustein,Shawn W Robinson,Stephen S Gottlieb et al.
Mordecai P Blaustein et al.
Foxglove and its constituents therapeutic agent digitalis have been used for centuries for the treatment of heart failure. All digitalis-like cardiotonic steroids enhance heart contraction through a mechanism involving the inhibition of the...
A career, in sequences [0.03%]
以序列藏人生职业之路尽斑斓
Claire M Fraser
Claire M Fraser
David A Kirby
David A Kirby
Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function [0.03%]
钠钾泵介导的信号转导：从蛋白质相互作用到细胞功能
Zijian Xie,Ting Cai
Zijian Xie
The Na+-K+--ATPase, or Na+ pump, is a member of the P-type ATPase superfamily. In addition to pumping ions, Na+-K+--ATPase is engaged in assembly of multiple protein complexes that transmit signals to different intracellular compartments. T...
Scott E Counts,Sylvia E Perez,Stephen D Ginsberg et al.
Scott E Counts et al.
Galanin (GAL) and GAL receptors (GALR) are overexpressed in limbic brain regions associated with cognition in Alzheimer disease (AD). The functional consequences of this overexpression are unclear. Because GAL inhibits cholinergic transmiss...
Sandro Yong,Xiaoli Tian,Qing Wang
Sandro Yong
Mutations in ion channels have been implicated in the formation of long QT syndrome (LQTS). However, Mohler et al. have recently uncovered a role for ankyrin-B, a non-ion channel protein, in type IV LQTS. Calcium signalling is altered, and ...
Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint [0.03%]
Aurora-A过表达导致微管-着丝点连接检测点失效
Stéphanie Dutertre,Claude Prigent
Stéphanie Dutertre
The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistanc...
Harald Wajant
Harald Wajant
In some cases, treatment of ovarian cancer cells with tumor necrosis factor-alpha can induce an apoptotic signal leading to the death of these cells; however, many ovarian malignancies are resistant to the effects of TNF-alpha. A new public...