Benjamin M Gaston,Jeannean Carver,Allan Doctor et al.
Benjamin M Gaston et al.
S-Nitrosylated proteins form when a cysteine thiol reacts with nitric oxide (NO) in the presence of an electron acceptor to form an S-NO bond. Under physiological conditions, this posttranslational modification affects the function a wide a...
LTP may trigger addiction [0.03%]
LTP可能引发上瘾
Marina E Wolf
Marina E Wolf
Differing classes of abused drugs utilize different mechanisms of molecular pharmacological action yet the overuse of these same drugs frequently leads to the same outcome: addiction. Similarly, episodes of stress can lead to drug-seeking b...
D A Henderson
D A Henderson
They had said that it couldn't be done-the worldwide eradication of smallpox. To hear D.A. Henderson tell it, the job of leading the World Health Organization's initiative to conquer the disease in the 1960s and 1970s rather fell into his l...
Seiya Miyamoto,Anthony S LaMantia,Gary E Duncan et al.
Seiya Miyamoto et al.
Despite great progress in basic schizophrenia research, the conclusive identification of specific etiological factors or pathogenic processes in the illness has remained elusive. The convergence of modern neuroscientific studies in molecula...
Portrait of a killer: the mitochondrial apoptosome emerges from the shadows [0.03%]
杀手的画像：线粒体凋亡体浮出水面
Michelle M Hill,Colin Adrain,Seamus J Martin
Michelle M Hill
Apoptosis (programmed cell death) is a physiological process used to eliminate superfluous, damaged, infected, or aged cells in multicellular organisms. During apoptosis the cellular architecture is dismantled from within in a highly contro...
Mechanisms of synaptic plasticity: from membrane to intracellular AMPAR trafficking [0.03%]
突触可塑性的机制：从膜到细胞内的AMPA受体转运
J Julius Zhu
J Julius Zhu
Brief periods of repetitive neural firing onto adjacent neurons can lead to changes in synaptic plasticity, that is, changes in the make-up of macromolecular complexes located at synapses. This process includes the regulated trafficking of ...
Rapid extranuclear signaling by the estrogen receptor (ER): MNAR couples ER and Src to the MAP kinase signaling pathway [0.03%]
雌激素受体（ER）的快速细胞核外信号转导：MNAR将ER和Src与MAP激酶信号传导途径偶联起来
Dean P Edwards,Viroj Boonyaratanakornkit
Dean P Edwards
In addition to their well-studied ability to transactivate the expression of many genes, estrogen receptors (ERs) also effect cytoplasmic changes occurring too quickly to be accounted for by gene expression. Indeed, these immediate, "nongen...
Palmer Taylor
Palmer Taylor
Blood-brain barrier drug targeting: the future of brain drug development [0.03%]
血脑屏障靶向给药：未来大脑药物研发的方向
William M Pardridge
William M Pardridge
As human longevity increases, the likelihood of the onset of diseases of the brain (and other organs) also increases. Clinical therapeutics offer useful long-term treatments, if not cures, if drugs can be delivered appropriately and effecti...
Holger Nilsson,Christian Aalkjaer
Holger Nilsson
That smooth muscles dilate and contract rhythmically has been known for a long time and the phenomenon has been studied for nearly as long. However, the causes and effects of smooth muscle oscillation (termed vasomotion) are far from clear....