Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention? [0.03%]
与精神分裂症相关的GABA能功能表观遗传沉默的下调：潜在的药物干预作用？
Erminio Costa,Dennis R Grayson,Alessandro Guidotti
Erminio Costa
Douglas A Bayliss,Jay E Sirois,Edmund M Talley
Douglas A Bayliss
F Peter Guengerich
F Peter Guengerich
Kazuyoshi Yonezawa
Kazuyoshi Yonezawa
Mark J Smyth,Michael H Kershaw
Mark J Smyth
Deogracia Cornelio,Sara Warber
Deogracia Cornelio
Harry Smith
Harry Smith
Jason Matthews,Jan-Ake Gustafsson
Jason Matthews
The biological actions of estrogens are mediated by estrogen binding to one of two specific estrogen receptors (ERs) ERalpha and ERbeta, which belong to the nuclear receptor superfamily, a family of ligand-regulated transcription factors. E...
PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling [0.03%]
PLC-epsilon：Ras、Rho和Gαβγ介导信号转导的共同效应蛋白
Michele R Wing,David M Bourdon,T Kendall Harden
Michele R Wing
The conceptual segregation of G protein-stimulated cell signaling responses into those mediated by heterotrimeric G proteins versus those promoted by small GTPases of the Ras superfamily is no longer vogue. PLC-epsilon, an isozyme of the ph...
Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease [0.03%]
G蛋白偶联受体的磷酸化：心病中的G蛋白偶联受体激酶
Jonathan A Hata,Walter J Koch
Jonathan A Hata
In the heart, beta -adrenergic receptors (beta ARs), members of the superfamily of G protein-coupled receptors (GPCRs), modulate cardiac responses to catecholamines. beta AR signaling, which is compromised in many cardiac diseases (e.g., co...