Stanley Scheindlin
Stanley Scheindlin
Emily M Jutkiewicz
Emily M Jutkiewicz
Activation of the delta-opioid receptor (DOR) system produces an interesting behavioral profile distinct from that of other opioids. Unlike mu- and kappa-opioid agonists, delta-opioid agonists alone have limited pain-relieving qualities as ...
Christian C Felder,Amy K Dickason-Chesterfield,Steven A Moore
Christian C Felder
Cannabinoids, in the form of marijuana plant extracts, have been used for thousands of years for a wide variety of medical conditions, ranging from general malaise and mood disorders to more specific ailments, such as pain, nausea, and musc...
Cancer stem cells: redefining the paradigm of cancer treatment strategies [0.03%]
癌症干细胞：重新定义癌症治疗策略的范式
Michael Dean
Michael Dean
Cancer has been known to arise from long-lived cells in the body and to possess properties in common with undifferentiated, embryonic cells. Recent findings of a population of cells in solid tumors resembling stem cells supports a stem cell...
Thomas E Willnow,Olav M Andersen
Thomas E Willnow
Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death? [0.03%]
肿瘤细胞中失去caspase-8：克服整合素介导的死亡的机制？
Izabela Podgorski,Bonnie F Sloane
Izabela Podgorski
Stanley Scheindlin
Stanley Scheindlin
Bi-Sen Ding,Thomas Dziubla,Vladimir V Shuvaev et al.
Bi-Sen Ding et al.
Targeted drug delivery to endothelial cells lining the vascular lumen will provide effective, precise and safe therapeutic interventions for treatment of diverse disease conditions. Rational design of such drug delivery systems (DDS) includ...
Donna W Lee,Julie K Andersen,Deepinder Kaur
Donna W Lee
Iron is essential for many biological processes however excess concentrations can be harmful to many tissues. Its amounts must therefore be carefully regulated in all cells of the body including those in the brain. Increased amounts of iron...
Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders [0.03%]
组胺H3受体拮抗剂：治疗肥胖和认知障碍的药物研发进展与前景
Timothy A Esbenshade,Gerard B Fox,Marlon D Cowart
Timothy A Esbenshade
The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a role in cognitive and homeostatic functions. Drug discovery efforts by numerous pha...