Androgen Receptor (AR) Expression in Invasive Male Breast Carcinoma (MBC): An International Multi-Institutional Review of 168 Cases Emphasizing the Potential Use of AR as a Therapeutic Target [0.03%]
雄激素受体（AR）在侵袭性男性乳腺癌（MBC）中的表达：对168例国际多中心研究的回顾性分析，强调了将AR作为潜在治疗靶点的可能性
Simona Stolnicu,Denisa Moncea,Alis Dema et al.
Simona Stolnicu et al.
Poroid Condyloma Versus Poroma With Atypias Because of Human Papillomavirus Infection [0.03%]
人乳头瘤病毒感染引起的皮样乳头状疣与异型皮样瘤
Angel Fernandez-Flores,David S Cassarino
Angel Fernandez-Flores
We present the case of a 43-year-old white man with a complex lesion at the base of the penis that combines features of both a poroma and a condyloma with human papillomavirus (HPV) infection, atypias, and focal ductal differentiation. It w...
IgG4 Expression in Primary Cutaneous Marginal Zone Lymphoma: A Multicenter Study [0.03%]
以边缘区淋巴瘤为主的IgG4表达多中心研究
Aieska De Souza,Judith A Ferry,Daniel R Burghart et al.
Aieska De Souza et al.
Background: Primary cutaneous marginal zone lymphoma (PCMZL) is the second most common B-cell lymphoma of the skin. A recent study has demonstrated a strikingly high prevalence of immunoglobulin (Ig)G4 expression in PCMZL...
Discordance Rate in Estrogen Receptor, Progesterone Receptor, HER2 Status, and Ki67 Index Between Primary Unifocal and Multiple Homogenous Breast Carcinomas and Synchronous Axillary Lymph Node Metastases Have an Impact on Therapeutic Decision [0.03%]
雌激素受体、孕激素受体、HER2状态和Ki67指数在原发单灶及多灶同质乳腺癌与同步腋窝淋巴结转移中的不一致影响治疗决策
Rares Georgescu,Monica Boros,Denisa Moncea et al.
Rares Georgescu et al.
Background: We aimed to demonstrate that in breast carcinomas the tumor profile is not stable during the metastatic process, with impact on therapeutic decisions. ...
Modified Nanoantibodies Increase Sensitivity in Avidin-Biotin Immunohistochemistry [0.03%]
改良的纳米抗体提高了avidin-biotin免疫组化敏感性
Anthony Wong,Chelsea Sykora,Lewis Rogers et al.
Anthony Wong et al.
Revealing the spatial arrangement of molecules within a tissue through immunohistochemistry (IHC) is an invaluable tool in biomedical research and clinical diagnostics. Choosing both the appropriate antibody and amplification system is para...
Comparison of β-Catenin and LEF1 Immunohistochemical Stains in Desmoid-type Fibromatosis and its Selected Mimickers, With Unexpected Finding of LEF1 Positivity in Scars [0.03%]
β-catenin和LEF1免疫组化在纤维瘤病及其选定类似病变中的比较以及瘢痕组织中意外发现LEF1阳性
Youran Zou,Yaxia Zhang,James Church et al.
Youran Zou et al.
β-catenin immunohistochemical stain can be useful in the diagnosis of many tumors including desmoid-type fibromatosis (DTF). Lymphoid enhancer-factor 1 (LEF1), a recently emerged marker, is part of the Wnt pathway with β-catenin but has n...
Gain of TP53 Mutation in Imatinib-treated SDH-Deficient Gastrointestinal Stromal Tumor and Clinical Utilization of Targeted Next-generation Sequencing Panel for Therapeutic Decision Support [0.03%]
伊马替尼治疗后SDH缺陷型胃肠间质瘤中TP53基因突变的 acquire 及其在精准医疗中的应用研究
Christina H Wei,Jonas Pettersson,Mihaela Campan et al.
Christina H Wei et al.
Patients with succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST) have few therapeutic options. Despite lack of KIT or platelet-derived growth factor receptor A (PDGFRA) driver mutations, SDH-deficient GISTs displa...
Precision Medicine Starts With Preanalytics: Real-Time Assessment of Tissue Fixation Quality by Ultrasound Time-of-Flight Analysis [0.03%]
精准医疗始于前分析：通过超声飞行时间分析实时评估组织固定质量
Melissa L Lerch,Daniel R Bauer,David Chafin et al.
Melissa L Lerch et al.
Personalized medicine promises diagnosis and treatment of disease at the individual level and relies heavily on clinical specimen integrity and diagnostic assay quality. Preanalytics, the collection and handling steps of a clinical specimen...
Mitotic Index Determined by Phosphohistone H3 Immunohistochemistry for Precise Grading in Follicular Lymphoma [0.03%]
采用磷酸组蛋白H3免疫组织化学法确定有丝分裂指数以精确分级滤泡性淋巴瘤
Judit Bedekovics,Gábor Irsai,Katalin Hegyi et al.
Judit Bedekovics et al.
The World Health Organization classification recommends follicular lymphoma (FL) grading (G1-3) by considering centroblast number, while also suggesting its influence on disease outcome. As centroblast counting and other proliferation marke...
Maria C Mengoli,Riccardo Valli,Gian F Zannoni
Maria C Mengoli