Xavier Catteau,Manon Charry,Justine Allard et al.
Xavier Catteau et al.
Background: Breast cancer is the most common form of cancer diagnosed in women. Breast cancer cells gain the expression of mesenchymal-specific genes in a process known as epithelial-mesenchymal transition (EMT). RhoJ, a ...
Prognostic Biomarkers in Ductal Carcinoma in Situ: An Interobserver Agreement Study [0.03%]
导管原位癌的预后生物标志物：一项组间一致性研究
Rachel L Stewart,Daniel S Hippe,Rebeca Alvarez et al.
Rachel L Stewart et al.
Ductal carcinoma in situ (DCIS) is a noninvasive form of breast cancer that accounts for 15% to 25% of all new breast cancer diagnoses. Clinical management approaches for DCIS include surgical excision, radiotherapy, and endocrine therapy (...
TROP2, Cyclin D1, and Ki-67 as Prognostic Markers of Aggressive Pituitary Adenoma [0.03%]
TROP2、Cyclin D1和Ki-67作为侵袭性垂体腺瘤预后标志物的研究
Aziza E Abdelrahman,Eman E Fayed,Hassan Abaza et al.
Aziza E Abdelrahman et al.
Pituitary adenomas have highly variable biological behavior, and reliable biomarkers are needed to distinguish indolent from aggressive tumors. This study evaluates the expression of TROP2, Cyclin D1, and Ki-67 as prognostic factors in pitu...
A High-Grade CD34-Positive Spindle Cell Sarcoma of the Palm Revealing an Unexpected TPM3::NTRK1 Fusion: A Diagnostic Pitfall With Major Therapeutic Implications [0.03%]
手掌起源的CD34阳性肉瘤样癌的一种特殊类型：TPM3::NTRK1融合基因导致的诊断陷阱及重要的治疗意义
Ayoub Nahal,Mahmoud El Kaissi,Suzan A Mbaideen et al.
Ayoub Nahal et al.
NTRK-rearranged spindle cell neoplasms are increasingly recognized soft-tissue sarcomas that can closely mimic other CD34-positive spindle cell tumors, particularly dermatofibrosarcoma protuberans (DFSP) and solitary fibrous tumor (SFT). Fa...
A Robust Protocol for the Establishment, Expansion, Bio-Banking, and Molecular Profiling of Triple-Negative Breast Cancer Organoids [0.03%]
三阴性乳腺癌类器官的建立、扩增、生物银行和分子特征分析的稳健协议
Prabhjot Kaur,Shalmoli Bhattacharyya,Parul Gupta et al.
Prabhjot Kaur et al.
Patient-derived organoids (PDOs) offer a powerful in vitro platform to model cancer biology, investigate therapeutic responses, and personalize treatment strategies. Here, we describe a comprehensive and reproducible protocol for establishi...
Tumorigenesis of Hepatocellular Carcinoma Related to Metabolic Disorders With a Focus on the Hippo Pathway [0.03%]
与代谢紊乱相关的肝细胞癌肿瘤发生重点关注Hippo信号通路
Haruto Nishida,Keiko Matsuura,Tsutomu Daa
Haruto Nishida
The Hippo pathway has been implicated in the tumorigenesis of hepatocellular carcinoma (HCC). We aimed to determine the expression of Hippo pathway-related proteins in HCC using immunohistochemical staining and compare the data among patien...
Golgi-Pattern PDGFRA Immunoreactivity Correlates With PDGFRA Mutation Status in Gastric Epithelioid and Mixed-Type Gastrointestinal Stromal Tumors [0.03%]
胃肠道间质瘤中戈尔吉氏染色PDGFRA免疫反应性与PDGFRA突变状态相关性研究
Rola H Ali,Maram Alwazan,Smiley George et al.
Rola H Ali et al.
Gastrointestinal stromal tumors (GISTs) with PDGFRA mutations represent a distinct subset with characteristic clinicopathological features and important therapeutic implications. The diagnostic performance of PDGFRA immunohistochemistry (IH...
HER2 Immunohistochemical Expression and Fluorescent In Situ Hybridization (FISH) Testing in Clear Cell Carcinoma of the Gynecologic Tract [0.03%]
妇科生殖道透明细胞癌的HER2免疫组化表达及原位荧光杂交(FISH)检测结果分析
Khaled S Mohamed,Preetha Ramalingam,Barrett C Lawson et al.
Khaled S Mohamed et al.
The DESTINY-PanTumor02 phase II trial, showing a remarkable response to fam-trastuzumab deruxtecan-nxki (Enhertu), has triggered an increase in HER2 testing for drug eligibility. We evaluated HER2 immunohistochemical (IHC) and FISH testing ...
Clinicopathological Significance of Leucine-rich Repeat-containing 15 in Distal Extrahepatic Bile Duct Carcinoma [0.03%]
富含亮氨酸的重复序列包含蛋白15在远端肝外胆管癌中的临床病理意义
Jihyun Chun,Deok-Beom Jung,Jinho Shin et al.
Jihyun Chun et al.
Leucine-rich repeat-containing 15 (LRRC15) is a membrane protein whose overexpression has been linked to poorer survival outcomes in various malignant neoplasms. However, its role in distal extrahepatic bile duct carcinoma (DBDC) remains un...