Peroxisome Proliferator-Activated Receptor (PPAR) Expression Correlates With Tumor Grade and Prognostic Outcome in Meningiomas [0.03%]
过氧化物酶体增殖激活受体（PPAR）在脑膜瘤中的表达与肿瘤分级和预后相关性研究
Sanjana S James,Hari S Malla,Vishnupriya Gopalakrishnan et al.
Sanjana S James et al.
The present study assessed the expression of different isoforms of PPAR, an important regulator of cell metabolism and proliferation, in meningiomas and correlated it with different clinicopathological variables and clinical outcomes. A tot...
Summary and Analysis of Molecular Biological Changes, PD-L1 Immune Status and Clinicopathological Features of 78 Cases of Papillary Thyroid Carcinoma ( [0.03%]
78例乳头状甲状腺癌分子生物学改变、免疫状态及临床病理特征总结与分析
Xiaoteng Sun,Zhengyan He,Weijie Yu et al.
Xiaoteng Sun et al.
To observe and analyze the variation status of BRAF, K-RAS, N-RAS, RET, TERT and PIK3CA genes and the expression of PD-L1 immune factors in patients with papillary thyroid carcinoma (
Interrelationship Between SHH and TGF-beta in the Formation of Odontomas [0.03%]
SHH与TGF-β在牙骨质瘤形成中的相互关系研究
Glória Maria de França,Cláudia Nunes de Oliveira,Roseana de Almeida Freitas et al.
Glória Maria de França et al.
The SHH signaling regulates cell proliferation in the ectomesenchyme, thus controlling tooth morphogenesis, while TGF-ß and bone morphogenetic proteins (BMPs) have been associated with reactionary and reparative dentinogenesis. The aim of ...
A Study on Differential Proteomics in Differentiated Gastric Adenocarcinoma With Low-grade Atypia Based on Paraffin-embedded Tissues [0.03%]
基于石蜡包埋组织低度不典型分化型胃腺癌差异蛋白质组学研究
Xuan-Tao Yang,Yu Zhang,Yue-Jiao Ding et al.
Xuan-Tao Yang et al.
In this study, we analyzed and characterized differentially expressed proteins in differentiated gastric adenocarcinoma with low-grade atypia for screening potential protein markers. We collected gastric tissue specimens from 90 patients tr...
The Suitability of Repurposed, Legacy HER2 Immunohistochemistry Assays for the Detection of HER2 Low and Ultralow Expression: Current Limitations and Potential Considerations [0.03%]
既往HER2免疫组化检测方法用于低表达和极低表达检测的局限性及未来考虑
Hadi Yaziji,Jason L Hornick,Megan L Troxell
Hadi Yaziji
Dennis P O&#x;Malley,Skyler Stephan,Andrew M Bellizzi
Dennis P O&#x;Malley
Klotho and LRP6 as Emerging Biomarkers in Gastric Adenocarcinoma: Expression Patterns and Clinical Relevance [0.03%]
胃腺癌中新兴生物标志物Klotho和LRP6的表达模式及临床意义
Marina B Youssef,Fatma A M Badary,Rabab M M Farghaly et al.
Marina B Youssef et al.
Gastric cancer (GC) is often diagnosed at an advanced stage, limiting treatment options and leading to poor outcomes. Klotho, a transmembrane anti-aging protein, generally functions as a tumor suppressor, while low-density lipoprotein recep...
A Practical Approach to the Diagnosis of Liver Metastases from Cancer of Unknown Primary: Application of Immunohistochemistry and an Update [0.03%]
未知原发灶肝转移癌的诊断及免疫组化应用的实用方法更新报告
Ali Koyuncuer,Tolga Canbak,Aylin Acar
Ali Koyuncuer
Cancers of unknown primary (CUP) are tumors whose site of origin remains undetectable despite thorough clinical, radiologic, and histopathologic evaluations. They make up about 2% to 3% of all epithelial tumors and generally have a poor pro...
Technical Challenges Faced in Validation of Immunohistochemical Assays That Test for Loss of Protein Expression-Case Studies in Succinate Dehydrogenase B and H3K27ME3 [0.03%]
免疫组化检测蛋白丢失的验证过程中遇到的技术挑战——琥珀酸脱氢酶B和H3K27ME3案例分析
Amos Zhi En Tay,Kwee Hua See,Wing Fat Chong et al.
Amos Zhi En Tay et al.
As compared to most immunohistochemistry (IHC) assays, a minority of IHC tests detect loss of protein expression in tumor tissues. One may encounter unique challenges in assay optimization, validation, and standardization, illustrated here ...
Xinpeng Liu,Peng Li,Wenjuan Jia et al.
Xinpeng Liu et al.
The melanin affects the pathologic diagnosis, so melanin bleaching must be performed. Our study was to investigate the effect of different melanin-bleaching methods on hematoxylin-eosin staining and immunohistochemical staining. We were use...