Expression of Phosphoinositide 3-Kinase p110α and p110β Subunits and PIK3CA Mutation in Patients With Advanced Gastric Carcinoma [0.03%]
磷脂酰肌醇-3-激酶p110α和p110β亚基及PIK3CA突变在晚期胃癌患者中的表达
Kyungeun Kim,Hyoun Wook Lee
Kyungeun Kim
Activation of phosphoinositide 3-kinase (PI3K) is pivotal for the activity of the oncogenic PI3K/AKT signaling pathway. This study assessed the expression of 2 PI3K isoform proteins, p110α and p110β, and PIK3CA mutational status in advanc...
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor [0.03%]
CHD4作为区分施万细胞瘤和恶性外周神经鞘瘤的潜在生物标志物研究
Chun-Chieh Wu,Mei-Ren Pan,Yu-Ching Wei et al.
Chun-Chieh Wu et al.
Cellular schwannoma is an uncommon variant of benign peripheral nerve sheath tumors, but is commonly misdiagnosed as malignant peripheral sheath tumor (MPNST). Conventional methods that are used to distinguish cellular schwannoma from MPNST...
P40 Immunostain Does Not Outperform p63 as a Myoepithelial Cell Marker in the Daily Practice of Breast Pathology [0.03%]
P40免疫组化染色不如p63染色能够有效识别肌上皮细胞而应用于乳腺病理的日常工作
Laila Khazai,Emmanuel Agosto-Arroyo,Marilin Rosa
Laila Khazai
P40 antibody has been shown to be a more specific squamous and basal cell marker compared with p63. As detection of myoepithelial cells (MECs) plays a critical role in breast pathology, and the fact that p40 targets an isoform of p63, this ...
Diagnostic Utility of Pax8, Pax2, and NGFR Immunohistochemical Expression in Pediatric Renal Tumors [0.03%]
Pax8、Pax2和NGFR免疫组织化学在儿科肾脏肿瘤诊断中的应用价值分析
Nicoleta C Arva,Jeffrey Bonadio,Elizabeth J Perlman et al.
Nicoleta C Arva et al.
Pediatric renal tumors (PRT) with small round blue or spindle cell morphology can be diagnostically challenging and only a limited number of immunohistochemical markers have been documented to help in the diagnosis: paired box (Pax) 2 and n...
Comparative Analysis of Multicolor Flow Cytometry and Immunohistochemistry for the Detection of Disseminated Tumor Cells [0.03%]
多色流式细胞术和免疫组化检测转移性肿瘤细胞的比较分析
Eszter Szánthó,Bettina Kárai,Gergely Ivády et al.
Eszter Szánthó et al.
Disseminating cells of a primary solid tumor may represent the origin of metastases and relapses. We aimed at comparing the diagnostic efficacy of multicolor flow cytometry (MFC) and morphology/immunohistochemistry (IHC) in the detection of...
An Immunoscore Using PD-L1, CD68, and Tumor-infiltrating Lymphocytes (TILs) to Predict Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer [0.03%]
基于PD-L1、CD68和肿瘤浸润淋巴细胞（TIL）的免疫评分用于预测新辅助化疗在侵袭性乳腺癌中的应答
Lauren E McLemore,Murali Janakiram,Joseph Albanese et al.
Lauren E McLemore et al.
Response to neoadjuvant chemotherapy (NAC) in invasive breast cancer (IBC) is partly regulated by the immune microenvironment. We evaluated immune checkpoint PD-L1 expression, presence of CD68+ cells of macrophage/monocytic lineage and stro...
Vascular Endothelial Growth Inhibitor, a Cytokine of the Tumor Necrosis Factor Family, is Associated With Epithelial-Mesenchymal Transition in Renal Cell Carcinoma [0.03%]
血管内皮生长抑制素是一种肿瘤坏死因子家族细胞因子，与肾细胞癌上皮间质转化相关
Qiang Zhao,Tiezhu Liu,Baoan Hong et al.
Qiang Zhao et al.
Previous studies have revealed that the activation of the epithelial-mesenchymal transition (EMT) endows metastatic properties upon cancer cells to promote invasion and migration. In this study, immunohistochemical analysis was performed in...
Diana M Lin,Sara Javidiparsijani,Alexandra Vardouniotis et al.
Diana M Lin et al.
Ectopic thyroid tissue is rare and controversial. Some experts consider it to always be metastatic thyroid carcinoma, whereas others consider it benign as long as it is restricted to few follicles without cytoarchitectural features of papil...
Detection of Loss of Heterozygosity (LOH) Using Circulating Cell-free DNA (cfDNA) by Fluorescence-based Multiplex PCR for Identification of Patients With Prostate Cancer [0.03%]
采用荧光多重PCR技术使用循环细胞游离DNA（cfDNA）检测杂合性丢失（LOH），以识别前列腺癌患者
S-Maryam Seyedolmohadessin,Mohammad T Akbari,Zahra Nourmohammadi et al.
S-Maryam Seyedolmohadessin et al.
Several lines of evidence suggest that loss of heterozygosity (LOH) in specific chromosomal regions is a common mechanism for the inactivation of tumor-suppressor genes that are implicated in the pathogenesis of prostate cancer (PCa). Short...
A Diagnostic Algorithm Combining Immunohistochemistry and Molecular Cytogenetics to Diagnose Challenging Melanocytic Tumors [0.03%]
结合免疫组化和分子细胞遗传学诊断疑难黑色素细胞肿瘤的算法
Sylvia Redon,Briac Guibourg,Matthieu Talagas et al.
Sylvia Redon et al.
Some melanocytic tumors are diagnostic challenges and require ancillary tools in helping the pathologists to determine their potential of malignancy. We intend to propose a diagnostic algorithm in helping to classify challenging melanocytic...