Technical Challenges Faced in Validation of Immunohistochemical Assays That Test for Loss of Protein Expression-Case Studies in Succinate Dehydrogenase B and H3K27ME3 [0.03%]
免疫组化检测蛋白丢失的验证过程中遇到的技术挑战——琥珀酸脱氢酶B和H3K27ME3案例分析
Amos Zhi En Tay,Kwee Hua See,Wing Fat Chong et al.
Amos Zhi En Tay et al.
As compared to most immunohistochemistry (IHC) assays, a minority of IHC tests detect loss of protein expression in tumor tissues. One may encounter unique challenges in assay optimization, validation, and standardization, illustrated here ...
Xinpeng Liu,Peng Li,Wenjuan Jia et al.
Xinpeng Liu et al.
The melanin affects the pathologic diagnosis, so melanin bleaching must be performed. Our study was to investigate the effect of different melanin-bleaching methods on hematoxylin-eosin staining and immunohistochemical staining. We were use...
Immunohistochemical Profiles of Dermatofibroma and Dermatofibrosarcoma Protuberans: A Scoping Review [0.03%]
皮肤纤维瘤和真皮纤维肉瘤的免疫组化特征：系统综述
Céline S C Hardy,Ali Razavi,Natalie Nunez et al.
Céline S C Hardy et al.
This review summarizes the immunohistochemical profiles of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) as reported by primary literature in the past 10 years. 63 studies were included in the review, with staining informat...
Prognostic Interplay of Caveolin1 and FOXC1 in Early Nonmetastatic Triple Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy [0.03%]
新辅助化疗早期三阴性乳腺癌中CAV1和FOXC1的预后交互作用
Asmaa H Mohamed,Aziza E Abdelrahman,Moamna M Fahmy et al.
Asmaa H Mohamed et al.
Triple-negative breast cancer (TNBC) lacks specific molecular targets. This highlights an obvious need to identify specific prognostic biomarkers to stratify patients and guide treatment decisions. We designed this study to evaluate CAV1 an...
Extranodal Histiocytic Sarcoma: A Clinicopathologic Study of Two Cases and Literature Review [0.03%]
网状组织郎罕氏细胞肉瘤二例临床病理学研究及文献复习
Jiayu Li,Qiong Liao
Jiayu Li
Histiocytic sarcoma (HS) is an extremely rare hematopoietic neoplasm derived from the monocytic/histiocytic/dendritic cell lineage. While sporadic cases of primary soft-tissue HS have been reported, its clinicopathological and molecular fea...
SMARCA4-deficient Non-small Cell Lung Carcinoma Harboring ALK Fusion: A Case Report [0.03%]
携带ALK融合的SMARCA4缺陷型非小细胞肺癌一例报告
Anne-Laure Désage,Simon Pointel,Eric Ezingeard et al.
Anne-Laure Désage et al.
SMARCA4-deficient non-small cell lung cancers are usually of poor prognosis and associated with smoking-related mutations. Here, we report the case of a SMARCA4-deficient non-small cell lung cancer (NSCLC) occurring in a non-smoker female a...
E2F7/Beclin-1 Pathway: Influencing Autophagy and EMT in ccRCC [0.03%]
E2F7/Beclin-1通路在透明细胞肾癌中的作用及其对自噬和上皮间质转化的影响研究
Junlin Zhao,Xinyi Yan,Dongmei Zhang et al.
Junlin Zhao et al.
Purpose: The deficiency of the current study of ccRCC lies in the incomplete understanding of the interaction between the E2F7/Beclin-1 pathway, autophagy, and EMT. This study aims to investigate the influence of the E2F7...
Immune Checkpoint Molecule Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Expressed in Lymphoma Subtypes With and Without Epstein-Barr Virus [0.03%]
免疫检查点分子吲哚胺2,3-双加氧酶1(IDO1)在有和无Epstein-Barr病毒的淋巴瘤亚型中表达
Kala Gnanasekaran Kiruthiga,Sheren Younes,Brindhavan N Jaeger et al.
Kala Gnanasekaran Kiruthiga et al.
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immune regulator involved in innate and acquired immunity and immune escape of tumors. Its expression in the tumor microenvironment of several solid tumors and lymphomas associated with Epstein-Bar...
CD71 in Tandem With Ki-67 and p53: Unraveling Their Prognostic and Diagnostic Significance in Esophageal Squamous Cell Carcinoma and Precursor Lesions [0.03%]
结合CD71、Ki-67和p53解开其在食管鳞状细胞癌及其前病变中的诊断及预后价值
Chuqiang Huang,Lili Tao,Xiaochen Ma et al.
Chuqiang Huang et al.
Background: Esophageal squamous cell carcinoma (ESCC), a commonly diagnosed cancer, poses challenges for early detection due to differentiation difficulties. ...
Monoamine Oxidase B Expression is a Prognostic Factor in Patients With Colorectal Cancer [0.03%]
单胺氧化酶B表达是结直肠癌患者预后的判断因素
Jiyoon Jung,Jeong Won Kim,Joo Young Kim
Jiyoon Jung
Monoamine oxidases (MAOs) produce hydrogen peroxide through an oxidative reaction and mediate the production of reactive oxygen species. MAO expression has been correlated with the prognosis in several tumor types. Accordingly, we aimed to ...