A Tissue Processing Technique for Improving Slide Preparation Quality of ESD Specimens [0.03%]
一种改进ESD标本切片制作质量的组织处理技术
Shanshan Huang,Xiaodan Fu,Yu Zhang et al.
Shanshan Huang et al.
Background: The efficacy of endoscopic submucosal dissection (ESD) procedures and subsequent treatment is predominantly reliant on precise pathologic evaluation, intricately linked to specimen sampling and paraffin sectio...
Solving the Puzzle of Hans' Algorithm (HA) Methodological Shortcomings: Canadian Harmonization of Hans' Algorithm for Diffuse Large B-Cell Lymphoma (DLBCL) and Development of Fit-for-Purpose Modified Hans' Algorithm (mHA) [0.03%]
汉斯算法（HA）方法学缺陷的破解：加拿大弥漫性大B细胞淋巴瘤（DLBCL）的汉斯算法和谐化及改良汉斯算法（mHA）的开发
Emina Torlakovic,Ariz Akhter,Allam Shawwa et al.
Emina Torlakovic et al.
Hans' algorithm (HA) is the most frequently used surrogate biomarker scheme for subtyping Diffuse large B-cell lymphoma (DLBCL) by the cell-of-origin (COO) into GCB and non-GCB subtypes. The originally published positive and negative predic...
Exploring the Calcitonin Receptor Relationship With Bone Resorption in Odontogenic Cysts [0.03%]
牙源性囊肿中降钙素受体与骨吸收的关系研究
Maria Luiza Diniz de Sousa Lopes,Débora Frota Colares,Tiago João da Silva Filho et al.
Maria Luiza Diniz de Sousa Lopes et al.
Understanding the pathogenesis of odontogenic cysts (OCs) may facilitate the development of alternative therapeutic strategies and improve patients' quality of life. Given calcitonin's role in regulating bone metabolism and its clinical app...
Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma [0.03%]
双相型滤泡性 dendritic细胞肿瘤的分子特征分析
Farhan Hassan,Theresa Boyle,Justin Palma et al.
Farhan Hassan et al.
Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm commonly found in extranodal sites with unclear pathogenesis. Tumor cells typically exhibit a spindled morphology, whereas epithelioid morphology is rarely reported. Here...
Megan L Troxell
Megan L Troxell
The recent clinical trials and regulatory approval of new antibody drug conjugates targeting HER2 protein (trastuzumab deruxtecan, T-DXd) has moved the bar in terms of therapy for breast cancer and other solid tumors. With new drugs and exp...
MHC Class I and PD-L1 Expression May Predict Treatment Response to Anti-PD-1/PD-L1 Therapy in Metastatic Triple-negative Breast Cancer Patients [0.03%]
MHC class I和PD-L1的表达或可预测转移性三阴性乳腺癌患者抗PD-1/PD-L1治疗的反应
Joseph L Maniaci,Hijun Ryu,Anne M Mills et al.
Joseph L Maniaci et al.
Although immune checkpoint inhibition has proven to be efficacious in a subset of breast cancer patients, there remains a heterogeneity in clinical responses. Major histocompatibility complex class I (MHC I) expression has been touted as a ...
IHC p53 Performance in NordiQC: Recalibration of IHC Assays is Needed [0.03%]
北欧质量控制组织中IHC p53检测性能分析：需要对IHC检测进行校准
Kristi Bøgh Anderson,Søren Nielsen,Rasmus Røge
Kristi Bøgh Anderson
The TP53 gene is the most frequently mutated gene in human cancers, with alterations occurring in ∼50% of all malignancies. When properly optimized, p53 immunohistochemistry (IHC) can serve as a reliable surrogate for detecting TP53 mutati...
Diagnostic Utility of T-PIT, PIT-1, and SF-1 in Differentiating Pituitary Neuroendocrine Tumors From Sinonasal and Skull Base Tumors [0.03%]
T-PIT、PIT-1和SF-1在区分垂体神经内分泌肿瘤与鼻窦和 skull base 肿瘤中的诊断价值
Hebatullah Elsafy,Nelli S Lakis,Mohammad Haeri et al.
Hebatullah Elsafy et al.
Pituitary adenoma (pituitary neuroendocrine tumor) can present a diagnostic pitfall when it involves the sinonasal tract ectopically or by direct extension due to morphologic and immunohistochemical overlap with sinonasal small round blue c...
Cooper D Rutland,Aihui Wang,Sabrina Zdravkovic et al.
Cooper D Rutland et al.
Paget disease (PD) is histologically characterized by malignant glandular epithelial cells singly or in clusters within the epidermis. PD most commonly involves the nipple, though it may also occur at extramammary sites. Immunohistochemistr...