Pediatric Mesenchymal Tumors [0.03%]
儿童间叶组织肿瘤
Omar Aljuboori,Ali G Saad
Omar Aljuboori
Vascular, fibrous/myofibroblastic, and myogenic tumors account for the majority of mesenchymal tumors in children. These tumors often show significant overlap in morphology and immunophenotype posing diagnostic difficulties and, thus, their...
Bone Matrix-forming Tumors [0.03%]
骨基质形成性肿瘤
Julio A Diaz-Perez,Andrew E Rosenberg
Julio A Diaz-Perez
Bone matrix-forming tumors are a group of neoplasms that exhibit differentiation toward any stage of osteoblast development. Their clinicopathologic features can resemble one another, yet their clinical management may vary significantly. Th...
Julio A Diaz-Perez,Andrew E Rosenberg
Julio A Diaz-Perez
The accurate diagnosis of giant cell-rich tumors of bone is challenging, especially in limited tissue samples. This diverse group of neoplasms have similar and often ambiguous clinical presentations, radiologic features, and morphologic cha...
Julio A Diaz-Perez,Andrew E Rosenberg
Julio A Diaz-Perez
Cartilage-forming tumors are a broad and diverse group of neoplasms frequently affecting the skeleton. Distinguishing between the members of this group is important because of significant differences in treatment and prognosis. Accurate dia...
Mesenchymal Tumors of the Tubular Gastrointestinal Tract (Non-GIST): The GI Pathologist's Approach [0.03%]
管状胃肠道间叶瘤（非GIST）：病理学家的诊断方法
Bence P Kővári,Gregory Y Lauwers
Bence P Kővári
Mesenchymal neoplasms of the gastrointestinal tract are rare compared with epithelial lesions. However, over the past few decades, the increasing volume of gastrointestinal endoscopy has expedited the recognition of several novel entities w...
Diagnosis and Risk Stratification of Ovarian Mucinous Neoplasms: Pattern of Invasion, Immunohistochemistry, and Molecular Diagnostics [0.03%]
卵巢粘液性肿瘤的诊断与风险分层：侵袭模式、免疫组化及分子诊断
Martin Köbel,Carlos Parra-Herran,Kylie Gorringe
Martin Köbel
Ovarian mucinous tumors are subclassified in multiple categories. Recent studies have highlighted issues in interobserver reproducibility. This review will focus on some new developments including criteria and ancillary tests that may help ...
Ovarian Sex Cord-Stromal Neoplasms: An Overview of Molecular Events and How to Correlate Morphology With Molecular Findings [0.03%]
卵巢性索-间质肿瘤：分子事件概览以及如何将形态学与分子发现相关联
Joseph T Rabban,W Glenn McCluggage
Joseph T Rabban
Since the discovery in 2009 that missence pathogenic variants/mutations in FOXL2 are extremely common in ovarian adult granulosa cell tumours, the last 2 decades have witnessed significant developments in our understanding of the molecular ...
Precancerous Lesions of HPV-independent Vulvar Squamous Cell Carcinoma: Clinicopathologic Consideration of an Evolving Spectrum [0.03%]
人乳头瘤病毒阴性外阴鳞癌癌前病变：对谱系演变的临床病理学考虑
Jaclyn Watkins,Oluwole Fadare
Jaclyn Watkins
HPV-independent squamous cell carcinomas of the vulva comprise the majority of vulvar cancers, but their putative precancers represent only a small proportion of the vulvar squamous intraepithelial lesions that are encountered in routine pr...
Daniel J Zaccarini,Lester D R Thompson
Daniel J Zaccarini
Laryngectomy margin assessment is an important part of patient care and can affect outcomes. There is no standard approach to grossing laryngectomy specimens, with variations in the published guidelines. A uniform approach to margin assessm...
Katherine Drews-Elger,Erik A Williams
Katherine Drews-Elger
Mesenchymal tumors of the skin are rare and clinically heterogeneous, and can represent diagnostic challenge for pathologists. Most of these lesions have overlapping clinical and histological features, thus the understanding of architectura...