Marie Rivera-Zengotita,Anthony T Yachnis
Marie Rivera-Zengotita
A major challenge in the routine practice of surgical neuropathology is the distinction between reactive astrocytosis, which may be because of non-neoplastic and neoplastic conditions, and a low-grade infiltrating diffuse astrocytoma [World...
Identifying Lynch syndrome in patients with endometrial carcinoma: shortcomings of morphologic and clinical schemas [0.03%]
子宫内膜癌患者林奇综合征识别的形态学和临床标准不足之处
Blaise A Clarke,Kumarasen Cooper
Blaise A Clarke
It has been suggested that reflex testing for Lynch syndrome (LS) using mismatch repair immunohistochemistry and/or microsatellite instability analysis in newly diagnosed colorectal carcinoma (CRC) patients is an emerging standard of care i...
Changqing Ma,Elizabeth M Brunt
Changqing Ma
In current medical practice, the clinical diagnosis of cirrhosis is rendered when a patient has suggestive imaging findings or features of portal hypertension (pHTN). Liver biopsy may be considered to assess potential underlying cause(s). C...
The clinical significance of recognizing distinct morphologic features of systemic diseases on breast biopsies [0.03%]
认识系统性疾病在乳腺活检中的形态特征的临床意义
Shahla Masood,Cindy Lee Davis,Melanie Jennifer Kubik
Shahla Masood
Prominent lymphocytic periductal inflammation has been previously described in association with diabetes mellitus type I and II, other autoimmune diseases such as lupus, thyroid disease, and connective tissue abnormalities, and even lymphom...
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations [0.03%]
前列腺癌的变异和特殊模式：临床病理学及鉴别诊断考虑因素
Samson W Fine
Samson W Fine
Beyond the typical acinar morphology observed in the majority of prostatic adenocarcinomas, a spectrum of morphologic variants and prostate cancer subtypes exists. These unusual entities may be classified as: (1) cancer morphologies arising...
Succinate dehydrogenase-deficient tumors: diagnostic advances and clinical implications [0.03%]
琥珀酸脱氢酶缺陷型肿瘤：诊断进展与临床意义
Justine A Barletta,Jason L Hornick
Justine A Barletta
Just over 10 years ago, germline mutations in SDHD, a gene that encodes 1 of the 4 proteins of the succinate dehydrogenase (SDH) complex, were reported in a subset of patients with hereditary paraganglioma-pheochromocytoma syndrome. Since t...
Additional thoughts about juvenile hyaline fibromatosis and infantile systemic hyalinosis [0.03%]
关于透明纤维瘤病和婴儿期系统性类黏液积聚症的进一步思考
Rafael Denadai,Debora Romeo Bertola,Rafael Fantelli Stelini et al.
Rafael Denadai et al.
The role of pathology experts in defining practice gaps in continuing pathology education: what do we need to know and how can we find them? [0.03%]
病理学专家在继续病理学教育实践差距定义中的作用：我们需要知道什么以及如何找到它们？
Sarah Calkins,Fred Silva,Tarik Tihan
Sarah Calkins
Two of the most important issues in continuing pathology education are the definition of a content expert and the issue of recognizing the "practice gaps." Purposeful definition of these concepts are critical in recognizing how the expert c...
Rania Ahmed,Safa Al-Shaikh,Mohammed Akhtar
Rania Ahmed
More than a century has passed since the first description of Hashimoto thyroiditis (HT) as a clinicopathologic entity. HT is an autoimmune disease in which a breakdown of immune tolerance is caused by interplay of a variety of immunologic,...
Elizabeth G Demicco,Robert G Maki,Dina C Lev et al.
Elizabeth G Demicco et al.
Soft tissue sarcomas are an uncommon and diverse group of more than 50 mesenchymal malignancies. The pathogenesis of many of these is poorly understood, but others have begun to reveal the secrets of their underlying mechanisms. With consid...