Rossana N Lazcano Segura,Mai P Hoang
Rossana N Lazcano Segura
BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome is due to germline mutation of BAP1, a tumor suppressor gene. Patients with this syndrome has an increased susceptibility to the development of uveal melanomas, cutaneous melan...
Large Cell Neuroendocrine Carcinoma of the Lung: In Search for a Better Definition [0.03%]
大细胞神经内分泌肺癌：更好的定义迫在眉睫
David Suster,Saul Suster
David Suster
Pulmonary large cell neuroendocrine carcinoma (LCNEC) represents a controversial entity that has been associated with difficulties for diagnosis. The sources for these difficulties are multiple, including lack of stringent morphologic crite...
Raima Memon,Romil Saxena
Raima Memon
The list of genetically defined causes of cholestatic liver diseases continues to expand; it currently includes mutations affecting bile acid synthesis, basolateral and apical membrane transporters, bile duct development, canalicular tight ...
Daniel A Arber,James R Cook
Daniel A Arber
Michael Michal,Steven D Billings,Thomas Brenn
Michael Michal
Over the past few years, several fusion genes have been reported in dermal-based tumors, resulting in the activation of the microphthalmia (MITF) signalling pathway and a melanocytic phenotype by immunohistochemistry. The best-studied examp...
Multimodal Generative AI for Anatomic Pathology-A Review of Current Applications to Envisage the Future Direction [0.03%]
多模态生成式AI在解剖病理学中的应用现状及未来展望综述
Ehsan Ullah,Mirza Mansoor Baig,Asim Waqas et al.
Ehsan Ullah et al.
This review focuses on the purported applications of multimodal Gen-AI models for anatomic pathology image analysis and interpretation to predict future directions. A scoping review was conducted to explore the applications of multimodal Ge...
Advances in Hepatocellular Carcinoma: Molecular Insights, Histologic Subtypes, and Differential Diagnosis [0.03%]
原发性肝细胞癌的研究新进展：分子机制、组织学分类及鉴别诊断
Wei Zheng,Yulin Haw,Hanlin L Wang
Wei Zheng
Significant advancements over the past 2 decades have reshaped our understanding and diagnostic capabilities for hepatocellular carcinoma (HCC). These advancements span molecular insights into key driver gene mutations and chromosomal aberr...
Despoina Myoteri,Stratigoula Sakellariou,Dina G Tiniakos
Despoina Myoteri
Autoimmune hepatitis (AIH) is a rare immune-mediated chronic liver disease that is diagnosed based on a combination of biochemical, immunologic, and histologic features and the exclusion of other causes of liver disease. According to the ne...
Diagnostic Approach to Myeloproliferative Neoplasms and Myelodysplastic/Myeloproliferative Neoplasms [0.03%]
骨髓增生性肿瘤和骨髓增生/增殖性肿瘤的诊断方法
Sonam Prakash,Attilio Orazi
Sonam Prakash
The International Consensus Classification (ICC) updated in 2022 the World Health Organization (WHO) classification of hematopoietic tumors (2016 revision of the 4th edition WHO classification). Although the major categories of myeloid neop...
Sarah L Ondrejka,Laurence de Leval
Sarah L Ondrejka
In recent decades, there have been many meaningful contributions to the pathology literature with respect to T-cell lymphoma pathogenesis and biology and improved diagnostics. We know more about disease classification, clinical characterist...