Current Challenges and Controversies in Colorectal Carcinoma Pathologic Staging-A Practical Guide [0.03%]
当前结直肠癌病理分期的挑战和争议——实用指南
Ian Clark,Ansa Mehreen,Paxton V Dickson et al.
Ian Clark et al.
The pathologic assessment of colorectal carcinoma specimens plays a crucial role in the therapeutic management of patients and disease prognostication. The TNM staging system is used globally and is a critical component of colorectal carcin...
Andrés M Acosta,Muhammad T Idrees,Daniel M Berney et al.
Andrés M Acosta et al.
Testicular sex cord-stromal tumors (TSCSTs) are relatively rare, representing ~5% of testicular neoplasms overall. Historically, TSCSTs have been classified into 3 major entities: Leydig cell tumor, Sertoli cell tumor, and granulosa cell tu...
#PathX: #PathTwitter's Transformation and a Discussion on Different Social Media Platforms Used by Pathologists in 2024 [0.03%]
#PathX：2024年PathTwitter的转型及其他病理学家使用的社交媒体平台讨论
Casey P Schukow,Lavisha S Punjabi,Fadi W Abdul-Karim
Casey P Schukow
#PathTwitter is a well-known virtual community that has historically been positive for pathologists, trainees, and medical students worldwide to communicate, collaborate, and connect for free. However, in 2023, the popular social media plat...
Jianping Zhao,Charles C Guo,Priya Rao
Jianping Zhao
Upper urinary tract urothelial carcinoma (UTUC) is an uncommon malignancy involving the renal pelvis and ureter. Careful pathologic analysis plays a critical role in the diagnosis and clinical management of UTUC. In combination with clinica...
DNA Damage Response and Mismatch Repair Gene Defects in Advanced and Metastatic Prostate Cancer [0.03%]
转移性前列腺癌的DNA损伤反应和错配修复基因缺陷
Dilara Akhoundova,Paola Francica,Sven Rottenberg et al.
Dilara Akhoundova et al.
Alterations in DNA damage response (DDR) and related genes are present in up to 25% of advanced prostate cancers (PCa). Most frequently altered genes are involved in the homologous recombination repair, the Fanconi anemia, and the mismatch ...
Multicystic Clear Cell Renal Tumors With Low-grade Nuclear Features: Time to Include TFE3 Translocation-associated Carcinomas [0.03%]
低级别核特征的多囊透明细胞肾肿瘤：是时候纳入TFE3基因易位相关癌了
Qi Cai,Jeffrey Gagan,Prasad Koduru et al.
Qi Cai et al.
TFE3 -rearranged renal cell carcinoma (RCC) is a distinct, uncommon entity with more than 20 different fusion partners identified; however, histomorphology may be suggestive of specific fusion partners in select TFE3 -rearranged RCCs. For e...
Renal Cell Carcinoma Associated With TSC/MTOR Genomic Alterations: An Update on its Expanding Spectrum and an Approach to Clinicopathologic Work-up [0.03%]
与TSC/MTOR基因组改变相关的肾细胞癌：不断扩大的谱系及其临床病理学检查方法的更新
Rajal B Shah,Rohit Mehra
Rajal B Shah
Renal cell carcinoma (RCC) with tuberous sclerosis complex (TSC)/mammalian target of rapamycin (MTOR) pathway-related genomic alterations have been classically described in hereditary TSC syndrome setting involving germline mutations, where...
Nipple Lesions of the Breast: An Update on Morphologic Features, Immunohistochemical Findings and Differential Diagnosis [0.03%]
乳腺乳头病变：形态学特征、免疫组化表现及鉴别诊断的新认识更新
Edi Brogi,Cristian Scatena
Edi Brogi
Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ...
Thomas J Lawton
Thomas J Lawton
The standard of care for invasive cancers of the breast has been and continues to be to evaluate them for breast prognostic markers: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 by immunohistochemis...
Is it Time to Retire the Term of Low-Grade Ductal Carcinoma in Situ and Replace it With Ductal Neoplasia? [0.03%]
是时候让导管原位癌这个术语退役，并用导管上皮不典型增生取代它了吗？
Shahla Masood,Melvin J Silverstein
Shahla Masood
As the leading cause of cancer morbidity and the second leading cause of cancer mortality among women, breast cancer continues to remain a major global public health problem. Consequently, significant attention has been directed toward earl...