Julia Adler,Anna Kuret,Natalie Längst et al.
Julia Adler et al.
The 3',5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase type I (cGKI aka PKGI) is a major cardiac effector acting downstream of nitric oxide (NO)-sensitive soluble guanylyl cyclase and natriuretic peptides (NPs), which sign...
Transduction Efficiency of Adenovirus Vectors in Endothelial Cells and Vascular Smooth Muscle Cells [0.03%]
腺病毒载体在内皮细胞和血管平滑肌细胞中的转导效率
Nikita Mokhashi,Robert Y Choi,Stephanie Cicalese et al.
Nikita Mokhashi et al.
Adenoviral vectors are useful tools in manipulating a gene of interest in vitro and in vivo, including in the vascular system. The transduction efficiencies of adenoviral vectors in vascular cells such as endothelial cells (ECs) and vascula...
Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells [0.03%]
染料木黄酮通过调节肺动脉平滑肌细胞内的钙稳态缓解单端孢霉毒素所致大鼠肺动脉高压作用机制研究
Fang Dong,Jun Zhang,Xiuqing Chen et al.
Fang Dong et al.
Chrysin (CH) is the main ingredient of many medicinal plants. Our previous study showed that CH could suppress hypoxia-induced pulmonary arterial smooth muscle cells proliferation and alleviate chronic hypoxia-induced pulmonary hypertension...
Use of Treprostinil in Pediatric Pulmonary Hypertension: Case Reports and Review of the Literature [0.03%]
曲前列环素治疗儿童肺动脉高压的用药经验及文献回顾
Arthur Gavotto,Fanny Thomas,Oscar Werner et al.
Arthur Gavotto et al.
Background: Add-on therapy with prostacyclin in pediatric refractory pulmonary hypertension (PH) poses a challenge, especially when considering continuous intravenous administration in younger children. A search for alter...
Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway [0.03%]
高基因胺通过ASK1信号途径改善心肾综合征大鼠的心脏和肾脏纤维化
Ting Deng,Zhenming Wei,Akindavyi Gael et al.
Ting Deng et al.
The pathogenesis of cardiorenal syndrome (CRS) is very complex, and currently there is no effective treatment for CRS. Higenamine (HI) has been shown to improve cardiac function in rats with heart failure. However, the role of higenamine in...
miR-4286/TGF-β1/Smad3-Negative Feedback Loop Ameliorated Vascular Endothelial Cell Damage by Attenuating Apoptosis and Inflammatory Response [0.03%]
miR-4286/TGF-β1/Smad3负反馈环通过抑制凋亡和炎症反应缓解血管内皮细胞损伤
Zhiyu He,Hao Xue,Peiying Liu et al.
Zhiyu He et al.
Atherosclerosis (AS), known as the chronic inflammatory disease, results from the dysfunction of vascular endothelial cells (VECs). Transforming growth factor-β1 (TGF-β1) has been reported to be induced by oxidized low-density lipoprotein...
Ursolic Acid Improves Monocrotaline-Induced Right Ventricular Remodeling by Regulating Metabolism [0.03%]
乌索酸通过调节代谢改善单端孢霉烯酮诱导的右心室重塑
Xiaojian Gao,Zeyu Zhang,Xin Li et al.
Xiaojian Gao et al.
Pulmonary arterial hypertension (PAH) is a progressive and malignant disease characterized by pulmonary small arteries and right ventricle (RV) remodeling that can lead to severe RV dysfunction and death. The current therapeutic targets for...
Nitrate Esters Alleviated Coronary Atherosclerosis Through Inhibition of NF-κB-Regulated Macrophage Polarization Shift in Epicardial Adipose Tissue [0.03%]
硝酸酯通过抑制心外膜脂肪组织中NF-κB调节的巨噬细胞极化转移来缓解冠状动脉粥样硬化
Chun-Yan Wei,Yong-Mei Wang,Lu Han et al.
Chun-Yan Wei et al.
Nitrate esters have been used in clinical practice for more than one century for the treatment of angina. Their clinical effectiveness is due to vasodilator activity in arteries through a method of delivering nitric oxide or a nitric oxide-...
Simvastatin Treatment Protects Myocardium in Noncoronary Artery Cardiac Surgery by Inhibiting Apoptosis Through miR-15a-5p Targeting: Erratum [0.03%]
辛伐他汀治疗通过抑制miR-15a-5p靶向的凋亡保护非冠状动脉心脏手术患者的心肌：勘误表
Published Erratum
Journal of cardiovascular pharmacology. 2020 Mar;75(3):267. DOI:10.1097/FJC.0000000000000790 2020
Deciphering the Dynamics and Therapeutic Potential of the Cardiac cGMP Cascade: An Update on Where We Are and What We Need to Know [0.03%]
心肌cGMP信号转导通路的动态及潜在治疗作用的再认识——现状与展望
Robert Lukowski,George W Booz
Robert Lukowski