Design and Rationale of the COMMIT-LAD registry: a Comprehensive analysis of medical and invasive treatment strategies for patients with significant Left Anterior Descending artery disease (COMMIT -LAD) [0.03%]
Roberto Bova,Janneke Bastings,Matteo Betti et al.
Roberto Bova et al.
Understanding the severity and anatomical pattern of coronary artery disease (CAD), particularly whether lesions are focal or diffuse, is critical in determining the most effective treatment strategy for patients with significant left anter...
Targeting Myocardial Energetics in Nonobstructive Hypertrophic Cardiomyopathy (nHCM): The Role of Ninerafaxstat [0.03%]
针对非梗阻性肥厚型心肌病(nHCM)心肌能量代谢的治疗：Ninerafaxstat的作用
Mohammad Hazique,Arihant Surana,Birgurman Singh et al.
Mohammad Hazique et al.
Non-obstructive hypertrophic cardiomyopathy (nHCM) is a condition that has significant therapeutic challenges due to its complicated pathophysiology. Beta-blockers (BB) and calcium channel blockers (CCB) are the existing treatment modalitie...
Cardioprotective effects of prophylactic ACE inhibitors in anthracycline-induced cardiotoxicity: a systematic review and meta-analysis of randomized trials [0.03%]
血管紧张素转换酶抑制剂预防蒽环类药物诱导的心脏毒性作用：随机试验的系统评价和meta分析
D Pizzi,L Fazzini,D Bassil et al.
D Pizzi et al.
This study aims to evaluate the efficacy of angiotensin-converting enzyme inhibitors (ACEi) in preventing anthracycline-induced cardiotoxicity in patients undergoing anthracycline-based chemotherapy. PubMed, Embase, and Cochrane databases w...
Sphingosine-1-Phosphate/Protein Kinase Cβ2 Signaling Mediates Hypercontraction of Mesenteric Arterial Smooth Muscle in Spontaneously Hypertensive Rats [0.03%]
鞘氨醇-1-磷酸/蛋白激酶Cβ2信号介导自发性高血压大鼠肠系膜动脉平滑肌的过度收缩
Haiyan Wang,Libing Deng,Yu Shan et al.
Haiyan Wang et al.
Protein kinase C (PKC) isoforms are crucial in hypertension-associated vascular dysfunction. Our previous study suggested that upregulated PKCβ2 contributed to aorta hypercontraction in spontaneously hypertensive rats (SHR). However, its r...
The Multifaceted Role of Angiopoietin-Like Proteins in Coronary Heart Disease: From Molecular Mechanisms to Clinical Translation [0.03%]
血管生成素样蛋白在冠心病中的作用及机制研究从分子机制到临床转化
Jie Tan,Jun Gu
Jie Tan
Coronary heart disease (CHD) remains a leading cause of cardiovascular morbidity and mortality worldwide, posing a global health threat. In recent years, angiotensin-like proteins (ANGPTLs) have emerged as a research focus in CHD due to the...
The more the lipid lowering agents, the merrier: welcome to combination therapy with cholesteryl ester transfer protein inhibitors! [0.03%]
降低血脂的药物越多越好：结合使用胆固醇酯转移蛋白抑制剂治疗！
Giacomo Frati,Mariangela Peruzzi,Salvatore Giordano et al.
Giacomo Frati et al.
Diurnal rhythm in blood pressure is preserved in hypertensive mice despite therapy with mineralocorticoid receptor antagonists [0.03%]
矿皮质类固醇受体拮抗剂治疗不会影响高血压小鼠的血压昼夜节律
Diana S Usai,Olga Kudryavtseva,Morten B Thomsen
Diana S Usai
Human arterial blood pressure follows a circadian rhythm, where pressure is highest during the day and lowest during the night. Patients with hypertension can have either a preserved rhythm or a dampened rhythm with a lower day-to-night dif...
Patients' and Healthcare Professionals' Perspectives in Managing Atherosclerotic Cardiovascular Disease: A Survey of Unmet Needs and Perceived Benefits of Treating Systemic Inflammation in Cardiovascular Diseases [0.03%]
动脉粥样硬化性心血管病的患者和医务人员的认知与未满足需求以及治疗系统性炎症的获益：调查报告
Brittany Weber,Delilah McCarty,Carey Robar et al.
Brittany Weber et al.
Few surveys have focused on a patient's journey or healthcare professionals' (HCPs') perspectives in treating inflammation in atherosclerotic cardiovascular disease (ASCVD). Patients with ASCVD (n=200) and HCPs (n=204) completed separate 30...
Magnitude of blood pressure reduction in response to levosimendan infusion independently predicts in-hospital mortality in patients with acute heart failure [0.03%]
左西孟丹滴注降压幅度可独立预测急性心力衰竭患者的住院死亡率
Gianmarco Sarto,Beatrice Simeone,Francesca Sbandi et al.
Gianmarco Sarto et al.
The impact of blood pressure (BP) reduction induced by levosimendan infusion on in-hospital mortality in patients with acute heart failure (AHF) and systolic ventricular dysfunction still needs to be clarified. We conducted a retrospective ...