Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury [0.03%]
视上核棕黑素受体2介导褪黑素的心肌缺血再灌注损伤保护作用
Chao Zhang,Jin-Bao Yang,Wei Quan et al.
Chao Zhang et al.
Previous studies have shown that melatonin (Mel) can effectively ameliorate myocardial ischemia/reperfusion (MI/R) injury, but the mechanism is yet to be fully elucidated. Mel receptors are expressed in the paraventricular nucleus (PVN), wh...
Yusuke Miyazaki,Fumito Ichinose
Yusuke Miyazaki
Sudden cardiac arrest is a leading cause of death worldwide. Although the methods of cardiopulmonary resuscitation have been improved, mortality is still unacceptably high, and many survivors suffer from lasting neurological deficits due to...
Helix B Surface Peptide Protects Cardiomyocytes From Hypoxia/Reoxygenation-induced Autophagy Through the PI3K/Akt Pathway [0.03%]
肽 Helix B Surface 肽通过 PI3K / Akt 信号通路保护心肌细胞免受缺血再灌注诱导的自噬作用
Yongluan Lin,Song Huang,Yequn Chen et al.
Yongluan Lin et al.
Background: Helix B surface peptide (HBSP) is a newly discovered tissue-protective erythropoietin derivative that provides benefits after myocardial ischemia/reperfusion. This study explores the cardioprotective effects o...
Acute Effects of Interleukin-1 Blockade Using Anakinra in Patients With Acute Pericarditis [0.03%]
阿那白滞素用于急性心包炎患者治疗的急性期 interleukin-1 阻断的影响
George F Wohlford,Leo F Buckley,Alessandra Vecchié et al.
George F Wohlford et al.
Interleukin-1 (IL-1) receptor antagonist (anakinra) has been shown to be effective in steroid-dependent recurrent pericarditis resistant to nonsteroidal anti-inflammatory drugs (NSAIDs) and colchicine. We sought to evaluate the acute effica...
Raj Kishore,Venkata N S Garikipati,Carolina Gonzalez
Raj Kishore
Circular RNAs (circRNAs) have recently been identified as a new class of long noncoding RNAs with gene regulatory roles. These covalently closed transcripts are generated when the pre-mRNA splicing machinery back splices to join a downstrea...
A Preliminary Study on the Effect and Mechanism of Breviscapine for Improving Insulin Resistance in HepG2 Cells [0.03%]
金丝桃素改善HepG2细胞胰岛素抵抗的作用及机制的初步研究
Fangyan Yan,Jibo Feng,Weiping Li et al.
Fangyan Yan et al.
Insulin resistance (IR) is known to be a critical factor, which can lead to the onset of type 2 diabetes. Traditional Chinese medicine (TCM) has special advantages in treating IR, but the active components and action mechanisms of most TCM ...
Inhibition of MyD88 by LM8 Attenuates Obesity-Induced Cardiac Injury [0.03%]
MYD88抑制剂LM8可减轻肥胖诱导的心肌损伤
Hui Liu,Wenjing Jia,Yelin Tang et al.
Hui Liu et al.
Obesity-induced cardiomyopathy involves chronic and sustained inflammation. The toll-like receptor 4 (TLR4) signaling pathway can associate innate immunity with obesity. Myeloid differentiation primary response 88 (MyD88), an indispensable ...
Long Noncoding RNA LNC_000898 Alleviates Cardiomyocyte Apoptosis and Promotes Cardiac Repair After Myocardial Infarction Through Modulating the miR-375/PDK1 Axis [0.03%]
长非编码RNA LNC_000898通过调节miR-375/PDK1轴缓解心肌细胞凋亡并促进心梗后心脏修复
Meiyu Yan,Qiliang Liu,Yumei Jiang et al.
Meiyu Yan et al.
Increasing evidence has confirmed that both long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) exert key roles in the pathogenesis of myocardial infarction (MI). Previous microarray assay results revealed that lncRNA LNC_000898 expression...
Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension [0.03%]
口服曲前列环素在肺动脉高压儿童患者中的药动学特征
Rachel K Hopper,D Dunbar Ivy,Delphine Yung et al.
Rachel K Hopper et al.
As part of a clinical trial, this study examined the pharmacokinetics (PK) of oral treprostinil (TRE) in children with pulmonary arterial hypertension. The trial consisted of the following 3 cohorts: transition from parenteral (cohort 1) or...
[Retracted] Physcion8-O-Β-Glucopyranoside Alleviates Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells Injury by Inducing Autophagy Via AMPK/SIRT1 Signaling [0.03%]
#[撤回]_physcion 8-o-β-d-葡萄糖苷通过ampk/sirt1信号诱导自噬减轻氧化低密度脂蛋白致人脐静脉内皮细胞损伤
Retraction of Publication
Journal of cardiovascular pharmacology. 2020 May;75(5):482. DOI:10.1097/FJC.0000000000000833 2020