Dihydroartemisinin Attenuates Pulmonary Hypertension Through Inhibition of Pulmonary Vascular Remodeling in Rats [0.03%]
双氢青蒿素通过抑制血管重构治疗大鼠肺动脉高压作用的研究
Ming Tang,Ruiyu Wang,Panpan Feng et al.
Ming Tang et al.
Pulmonary arterial hypertension (PAH) is a malignant disease characterized by pulmonary arterial remodeling because of the abnormal proliferation and migration of pulmonary arterial smooth muscle cells. Dihydroartemisinin (DHA), an artemisi...
Insight into the Pro-inflammatory and Profibrotic Role of Macrophage in Heart Failure With Preserved Ejection Fraction [0.03%]
心力衰竭保留射血分数中巨噬细胞促炎和促纤维化作用的再认识
Jin-Lian Shen,Xiao-Jie Xie
Jin-Lian Shen
The prevalence of heart failure (HF) with preserved ejection fraction (HFpEF) is higher than that of HF with reduced/midrange ejection fraction (HFrEF/HFmrEF). However, no evidence-based guidelines for managing HFpEF have been generated. Th...
cGMP Signaling in Cardiovascular Diseases: Linking Genotype and Phenotype [0.03%]
心血管疾病的cGMP信号转导：连接基因型和表型
Tan An Dang,Heribert Schunkert,Thorsten Kessler
Tan An Dang
Cyclic guanosine 3',5'-monophosphate (cGMP) is the key second messenger molecule in nitric oxide signaling. Its rapid generation and fate, but also its role in mediating acute cellular functions has been extensively studied. In the past yea...
ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARγ Expression [0.03%]
ALK7通过负向调控PPARγ表达促进血管平滑肌细胞表型转换
Fu-Han Gong,Wen-Lin Cheng,Quan Zhang et al.
Fu-Han Gong et al.
As a receptor for transforming growth factor-β, nodal and activin, activin receptor-like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. Howe...
Atrial Fibrillation in COVID-19: From Epidemiological Association to Pharmacological Implications [0.03%]
新冠肺炎中的房颤：从流行病学关联到药理学含义
Vincenzo Russo,Anna Rago,Andreina Carbone et al.
Vincenzo Russo et al.
Coronavirus disease 2019 (COVID-19) outbreak is a public health emergency of international concerns because of a highly pathogenic human coronavirus (HCoV), actually named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despit...
MiR-7-5p Enhances Cerebral Ischemia-Reperfusion Injury by Degrading sirt1 mRNA [0.03%]
MiR-7-5p通过降解sirt1 mRNA增强脑缺血再灌注损伤
Jing Zhao,Bo Wang
Jing Zhao
Cerebral ischemia-reperfusion (I/R) is a kind of neurovascular disease that causes serious cerebral damage. MicroRNAs (miRNAs) have been widely reported to participate in multiple diseases, including cerebral I/R injury. However, the exact ...
LOXL1-AS1/miR-515-5p/STAT3 Positive Feedback Loop Facilitates Cell Proliferation and Migration in Atherosclerosis [0.03%]
LOXL1-AS1/miR-515-5p/STAT3正反馈环促进动脉粥样硬化细胞增殖和迁移的作用及机制研究
Qiong Xie,Feng Li,Kangjun Shen et al.
Qiong Xie et al.
Existing research has elucidated the critical role of long noncoding RNAs (lncRNAs) in the progression of multiple human cardiovascular diseases, including atherosclerosis (AS). Nonetheless, whether long noncoding RNA LOXL1 antisense RNA 1 ...
The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity [0.03%]
新型非选择性钙激活的小电导钾通道抑制剂预防房颤的 atrio-selective Na+通道抑制新机制研究
Alexander Burashnikov,Hector Barajas-Martinez,Dan Hu et al.
Alexander Burashnikov et al.
The mechanisms underlying atrial-selective prolongation of effective refractory period (ERP) and suppression of atrial fibrillation (AF) by NS8593 and UCL1684, small conductance calcium-activated potassium (SK) channel blockers, are poorly ...
Mazen Kurdi,Piero Pollesello,George W Booz
Mazen Kurdi
Mibefradil Alleviates High-Glucose-induced Cardiac Hypertrophy by Inhibiting PI3K/Akt/mTOR-mediated Autophagy [0.03%]
米贝拉地尔通过抑制PI3K/Akt/mTOR介导的自噬缓解高糖诱导的心肌肥厚
Ling-Gong Zhao,Pei-Lin Li,Ying Dai et al.
Ling-Gong Zhao et al.
Cardiac hypertrophy causes heart failure and is associated with hyperglycemia in patients with diabetes mellitus. Mibefradil, which acts as a T-type calcium channel blocker, exerts beneficial effects in patients with heart failure. In this ...