FAP Promotes Pulmonary Artery Hypertension via Activation of the PTEN/PI3K/Akt Pathway [0.03%]
FAP通过激活PTEN/PI3K/Akt通路促进肺动脉高血压
Minghui Zhu,Fei Xu,Le Zhu et al.
Minghui Zhu et al.
Pulmonary arterial hypertension (PAH) is a severe disease characterized by significant pulmonary vascular remodeling and right ventricular dysfunction. Activated fibroblasts can induce collagen deposition around blood vessels, thereby promo...
Treating the Broken Heart: Role of Stellate Ganglion Block in Takotsubo Syndrome [0.03%]
治疗伤心综合征：星状神经节阻滞的作用
Chiara Giuliana,Simone Filomia,Marta Ricci et al.
Chiara Giuliana et al.
Takotsubo syndrome (TTS) is an acute stress-induced cardiomyopathy characterized by transient left ventricular dysfunction, often mimicking acute myocardial infarction but without obstructive coronary artery disease. While typically reversi...
Comparative LDL-C Lowering Efficacy of Non-Statin Therapies: Inclisiran is Better than Ezetimibe, PCSK9 inhibitors, and Bempedoic Acid [0.03%]
非他汀类降脂药物降低LDL-C疗效的比较：Inclisiran优于Ezetimibe、PCSK9抑制剂和Bempedoic Acid
Gaetano Santulli,Urna Kansakar,Stanislovas S Jankauskas et al.
Gaetano Santulli et al.
Methotrexate improves left ventricle systolic and diastolic function in induced Takotsubo myocardiopathy rats [0.03%]
甲氨蝶呤改善Takotsubo型心肌病大鼠左心室收缩和舒张功能
Maria Carolina Guido,Lucas Lage Marinho,Elaine Rufo Tavares et al.
Maria Carolina Guido et al.
Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy which is associated with important morbidity and in-hospital mortality. Microvascular dysfunction, inflammation and fibrosis may play crucial roles in TTS pathophysiology. Here we ...
miR-132 inhibition improves cardiac remodeling and function in a two-hit mouse model of heart failure with a preserved ejection fraction [0.03%]
抑制mir-132可改善两击小鼠房颤相关射血分数保留的心力衰竭中重构和功能紊乱的现象
Ying Wu,Meiyan Song,Wen Chen et al.
Ying Wu et al.
To investigate the impact of antimiR-132, a miR-132 antisense inhibitor, on cardiac remodeling and function in a two-hit mouse model of heart failure with preserved ejection fraction (HFpEF), as well as its underlying mechanism. Male C57BL/...
Types, Molecular Mechanisms and Potential Therapeutic Targets of Programmed Endothelial Cell Death in Atherosclerosis [0.03%]
动脉粥样硬化中内皮细胞程序性坏死的类型、分子机制和潜在治疗靶点
Lu Kuang,Qijun Chen,Zenghui Liu et al.
Lu Kuang et al.
Atherosclerosis (AS) is a chronic progressive disease that occurs in the inner walls of arteries. Endothelial dysfunction is a key component in the early stages of atherosclerosis. Unhealthy lifestyle factors (e.g., smoking), hypertension, ...
Cardiac-specific overexpression of Klotho attenuates paraquat-induced myocardial injury by enhancing the Nrf2/ARE signaling pathway [0.03%]
心脏特异性过表达Klotho通过增强Nrf2/ARE信号通路减弱百草枯引起的的心肌损伤
Xiao Qian Feng,Ai Ping Deng,Yi Qin Wu et al.
Xiao Qian Feng et al.
Paraquat, a widely used herbicide, is known to induce oxidative stress and inflammation, which leads to myocardial injury. Klotho, a protein with antioxidative and anti-inflammatory properties, has garnered as a potential cardioprotective f...
Genetic exploration of targeting the transient receptor potential cation channel subfamily member 6 [0.03%]
靶向瞬时受体电位阳离子通道亚家族成员6的遗传学探索
Christian Graesser,Nikita Panyam,Xiaofeng Qian et al.
Christian Graesser et al.
The transient receptor potential cation channel subfamily member 6 (TRPC6) represents an emerging druggable target with a broad therapeutic spectrum. TRPC6 Inhibitors are currently investigated for focal segmental glomerulosclerosis (FSGS),...
Differential Binding Affinities and Kinetics of Transthyretin Stabilizers [0.03%]
稳定transthyretin的结合亲和力及动力学差异性研究
Alan X Ji,Andreas Betz,Uma Sinha
Alan X Ji
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Dissociation of tetrameric transthyretin (TTR) is the triggering event in the pathogenic mechanism; destabilizing TTR mutations accelerate the process. The TTR ...