Current Practices and Perspectives on the Use of Intravenous Vasodilators in Acute Heart Failure: An International Survey [0.03%]
急性心力衰竭静脉血管扩张剂应用现状及国际专家共识展望的一项全球调查
Alessandro Galluzzo,Maurizio Bertaina,Julie K K Vishram-Nielsen et al.
Alessandro Galluzzo et al.
Although a solid pathophysiological rationale supports intravenous vasodilators (IVV) for acute heart failure (AHF), trial evidence is conflicting and international guidelines offer only weak recommendations. We conducted an international s...
Landscape of Berberine Targets: A Potential Pharmacological Insight for Heart failure Treatment [0.03%]
小檗碱靶点概览：心力衰竭治疗的潜在药理学见解
Siao Wen,Xiehong Liu,Liping Liu et al.
Siao Wen et al.
Berberine, the primary active compound in Coptis chinensis Franch., is well-known for its anti-infective, hypoglycemic, lipid-lowering, anti-tumor, and anti-inflammatory effects. This review summarizes the physicochemical and pharmacokineti...
Lactylation in Cardiovascular Diseases: Epigenetic Mechanisms and Therapeutic Potential [0.03%]
乳酰化在心血管疾病中的表观遗传机制与治疗潜力
Meican Ma,Chong Xu,Hong Zhou et al.
Meican Ma et al.
The global burden of mortality is largely attributable to cardiovascular diseases (CVDs), where altered metabolic homeostasis plays a critical role. The identification of lactylation as an epigenetic modification mediated by lactate has tra...
Integration of vascular smooth muscle cell phenotypic switching and senescence [0.03%]
血管平滑肌细胞表型转换和衰老的整合
Shiqi Deng,Xinglei Yin,Ruigong Zhu
Shiqi Deng
Cardiovascular diseases (CVDs) are life-threatening conditions with multifactorial causes. As the most abundant cells in the vascular wall, vascular smooth muscle cells (VSMCs) play a crucial role in regulating vascular tone. Under physiolo...
Zhuo-Nan Jia,Bo-Yu Zhang,Zhi-Yuan Gao et al.
Zhuo-Nan Jia et al.
Recently, Apigenin has been widely studied for its anti-atherosclerosis properties, but its mechanism remains to be further elucidated.This study aims to evaluate the expression of LOX-1, Bcl-2 and Bax in apigenin-treated atherosclerotic ra...
Giuseppe Biondi-Zoccai,Giacomo Frati,Roberto Carnevale et al.
Giuseppe Biondi-Zoccai et al.
Human-based technologies are revolutionizing cardiovascular pharmacology by offering innovative platforms that more accurately reflect human biology and disease mechanisms than traditional animal models. These approaches include tissue chip...
Effect of rosuvastatin and vitamin K on vascular calcification in a rat model of adenine induced chronic kidney disease [0.03%]
rosuvastatin和维生素K对腺嘌呤诱导慢性肾病大鼠模型血管钙化的影响
Sherouk S Shams,Mohamed T Ghoneim,Doaa A Ghareeb et al.
Sherouk S Shams et al.
Vascular calcification (VC) is prevalent in patients with chronic kidney disease and raises the risk of cardiovascular death. The study aimed to evaluate the protective effects of rosuvastatin and/or vitamin K on VC in a rat model of adenin...
Androgen replacement therapy for Torsades de Pointes in males: hormonal modulation as a novel antiarrhythmic strategy [0.03%]
用于男性Torsades de Pointes的雄激素替代疗法：激素调节作为新的抗心律失常策略
Riccardo Accioli,Pier Leopoldo Capecchi,Mohamed Boutjdir et al.
Riccardo Accioli et al.
Rationale and Design of the SOTA-THROMBOSIS Trial (ATRU-VI): Antithrombotic Activities of Sotagliflozin compared to Empagliflozin [0.03%]
SOTA-THROMBOSIS试验（ATRU-VI）的 rationale与设计：比较sotagliflozin和empagliflozin的抗血栓作用
Juan Antonio Requena-Ibáñez,Mohammad Urooj Zafar,Marcos Ferrandez-Escarabajal et al.
Juan Antonio Requena-Ibáñez et al.
While selective SGLT2 inhibitors improve heart failure (HF) outcomes, they do not consistently reduce atherothrombotic events (myocardial infarctions and strokes). Clinical trials with sotagliflozin, the first dual SGLT1/2 inhibitor, have s...
Intrapericardial Bleomycin for Malignant Pericardial Effusion: Revisiting a Targeted Pharmacologic Approach [0.03%]
恶性心包积液的心包内博来霉素治疗：重新审视靶向药物疗法
Danny L Rayes,Hira Latif,Syed Waqas Haider
Danny L Rayes
Malignant pericardial effusion, a complication of advanced malignancy, carries a poor prognosis and may be life-threatening in cases of cardiac tamponade. Treatment is challenging due to high recurrence rates. Management options include sur...