Rationale and Design of the SOTA-THROMBOSIS Trial (ATRU-VI): Antithrombotic Activities of Sotagliflozin compared to Empagliflozin [0.03%]
SOTA-THROMBOSIS试验（ATRU-VI）的 rationale与设计：比较sotagliflozin和empagliflozin的抗血栓作用
Juan Antonio Requena-Ibáñez,Mohammad Urooj Zafar,Marcos Ferrandez-Escarabajal et al.
Juan Antonio Requena-Ibáñez et al.
While selective SGLT2 inhibitors improve heart failure (HF) outcomes, they do not consistently reduce atherothrombotic events (myocardial infarctions and strokes). Clinical trials with sotagliflozin, the first dual SGLT1/2 inhibitor, have s...
Intrapericardial Bleomycin for Malignant Pericardial Effusion: Revisiting a Targeted Pharmacologic Approach [0.03%]
恶性心包积液的心包内博来霉素治疗：重新审视靶向药物疗法
Danny L Rayes,Hira Latif,Syed Waqas Haider
Danny L Rayes
Malignant pericardial effusion, a complication of advanced malignancy, carries a poor prognosis and may be life-threatening in cases of cardiac tamponade. Treatment is challenging due to high recurrence rates. Management options include sur...
Genetic and Epigenetic Biomarkers in Hypertension: Impact on the Effectiveness of Individualized Therapy: A Systematic Review [0.03%]
高血压的遗传和表观遗传生物标志物：对个体化治疗有效性的影啊：系统评价
Anderson Matheus Pereira da Silva,Elaine da Silva Torres,Maria da Vitória Santos do Nascimento et al.
Anderson Matheus Pereira da Silva et al.
Arterial hypertension (AH) affects over 1.28 billion adults globally, remaining a leading cause of cardiovascular morbidity and mortality. Despite effective therapies, suboptimal blood pressure control persists, highlighting the need for pr...
Effect of regular exercise and resveratrol on hypertension-induced cellular stress response and senescence in renal and vascular tissues of rats [0.03%]
规律锻炼和白藜芦醇对高血压大鼠肾组织和血管组织细胞应激反应及衰老的影响
Nur Banu Bal,Gökhan Sadi,Aykut Bostanci et al.
Nur Banu Bal et al.
Hypertension remains the leading cause of morbidity and mortality worldwide and requires more understanding of its molecular basis. This study investigated cellular stress responses and senescence signaling in vascular and renal tissues of ...
GPX4: A Key Regulator of Mitochondrial Function and Glycolysis in Pulmonary Artery Smooth Muscle Cells [0.03%]
GPX4：肺动脉平滑肌细胞线粒体功能和糖酵解的关键调节因子
Hongli Zhang,Jihong Ren,Yan He et al.
Hongli Zhang et al.
Pulmonary arterial hypertension (PAH) is a progressive cardiovascular disease characterized by elevated pulmonary arterial pressure and vascular remodeling. However, the underlying mechanisms remain unclear. This study reveals a novel mecha...
Relevance of CYP2D6 in the Efficacy and Toxicity of Flecainide in Patients with Atrial Fibrillation: A Cohort Study [0.03%]
卡维地洛在房颤患者氟卡尼疗效和毒性中的作用：队列研究
Mauro Trincado Ave,María Brión,Alejandro Blanco-Verea et al.
Mauro Trincado Ave et al.
A 25% flecainide dose reduction has been recommended for intermediate metabolisers (IMs); however, studies have yielded contradictory results, likely due to the lack of standardisation in CYP2D6 pharmacogenetic classifications. We aimed to ...
Innovation and Challenges in Preventive Cardiology: Highlights from ESC Preventive Cardiology 2025 [0.03%]
预防心脏病学的创新与挑战：ESC 2025预防心脏病学会议亮点
Svetlana Mosteoru,Giuseppe Biondi Zoccai,Luigi Spadafora
Svetlana Mosteoru
Rare but Severe Cardiovascular Complications of SARS-CoV-2 Vaccination: A Call for Awareness [0.03%]
警惕新冠疫苗罕见却严重的不良反应——同舟共“心”战疫情
Michele Marchetta,Michele Golino,John D Markley et al.
Michele Marchetta et al.
The extensive use of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines has played a crucial role in controlling the Coronavirus disease 2019 (COVID-19) pandemic, underscoring the remarkable advantages and efficacy of nov...
Perspectives on artificial intelligence in medical publishing: a survey of medical journal editors [0.03%]
医学期刊编辑对医学出版领域人工智能的看法调查研究
Giuseppe Biondi-Zoccai,Attilio Lauretti,Stefan Agewall et al.
Giuseppe Biondi-Zoccai et al.
Artificial intelligence (AI) has been increasingly integrated into medical publishing, hopefully improving efficiency and accuracy, but serious concerns persist regarding ethical implications, authorship attribution, and content reliability...
Phthalates and Cardiovascular Risk: A Call for Awareness in Clinical Practice [0.03%]
增塑剂与心血管风险——临床实践中应提高意识
Giuseppe Biondi-Zoccai,Vassilios S Vassiliou,Maria Camilla Palumbo et al.
Giuseppe Biondi-Zoccai et al.
Phthalates, widely used as plasticizers in industrial and medical products, are increasingly recognized as cardiovascular health disruptors. Their ubiquity poses a significant threat, particularly to patients with or at risk of cardiovascul...