Omaveloxolone promotes macrophage M2 polarization by activating the NRF2-Keap1 pathway and improves myocardial remodeling induced by pressure overload [0.03%]
Omaveloxolone通过激活NRF2-Keap1通路促进巨噬细胞M2极化并改善压力超负荷诱导的心肌重塑
Qian Li,Wei Chen,Zhi-Shuo Hu et al.
Qian Li et al.
Nuclear factor erythrocyte 2-associated factor 2 (Nrf2) is an important transcriptional regulator that plays a protective role in myocardial remodeling. Omaveloxolone (Omav) acts as an activator of Nrf2 and plays a protective role by decrea...
Heart Rate Lowering With Ivabradine and Burden of Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome [0.03%]
伊伐布雷定治疗体位性心动过速综合征患者的静息心率下降与症状负担的关系
Michele Marchetta,Rocio I Lopez,Austin C Hogwood et al.
Michele Marchetta et al.
Current Practices and Perspectives on the Use of Intravenous Vasodilators in Acute Heart Failure: An International Survey [0.03%]
急性心力衰竭静脉血管扩张剂应用现状及国际专家共识展望的一项全球调查
Alessandro Galluzzo,Maurizio Bertaina,Julie K K Vishram-Nielsen et al.
Alessandro Galluzzo et al.
Although a solid pathophysiological rationale supports intravenous vasodilators (IVV) for acute heart failure (AHF), trial evidence is conflicting and international guidelines offer only weak recommendations. We conducted an international s...
Landscape of Berberine Targets: A Potential Pharmacological Insight for Heart failure Treatment [0.03%]
小檗碱靶点概览：心力衰竭治疗的潜在药理学见解
Siao Wen,Xiehong Liu,Liping Liu et al.
Siao Wen et al.
Berberine, the primary active compound in Coptis chinensis Franch., is well-known for its anti-infective, hypoglycemic, lipid-lowering, anti-tumor, and anti-inflammatory effects. This review summarizes the physicochemical and pharmacokineti...
Lactylation in Cardiovascular Diseases: Epigenetic Mechanisms and Therapeutic Potential [0.03%]
乳酰化在心血管疾病中的表观遗传机制与治疗潜力
Meican Ma,Chong Xu,Hong Zhou et al.
Meican Ma et al.
The global burden of mortality is largely attributable to cardiovascular diseases (CVDs), where altered metabolic homeostasis plays a critical role. The identification of lactylation as an epigenetic modification mediated by lactate has tra...
Integration of vascular smooth muscle cell phenotypic switching and senescence [0.03%]
血管平滑肌细胞表型转换和衰老的整合
Shiqi Deng,Xinglei Yin,Ruigong Zhu
Shiqi Deng
Cardiovascular diseases (CVDs) are life-threatening conditions with multifactorial causes. As the most abundant cells in the vascular wall, vascular smooth muscle cells (VSMCs) play a crucial role in regulating vascular tone. Under physiolo...
Zhuo-Nan Jia,Bo-Yu Zhang,Zhi-Yuan Gao et al.
Zhuo-Nan Jia et al.
Recently, Apigenin has been widely studied for its anti-atherosclerosis properties, but its mechanism remains to be further elucidated.This study aims to evaluate the expression of LOX-1, Bcl-2 and Bax in apigenin-treated atherosclerotic ra...
Giuseppe Biondi-Zoccai,Giacomo Frati,Roberto Carnevale et al.
Giuseppe Biondi-Zoccai et al.
Human-based technologies are revolutionizing cardiovascular pharmacology by offering innovative platforms that more accurately reflect human biology and disease mechanisms than traditional animal models. These approaches include tissue chip...
Effect of rosuvastatin and vitamin K on vascular calcification in a rat model of adenine induced chronic kidney disease [0.03%]
rosuvastatin和维生素K对腺嘌呤诱导慢性肾病大鼠模型血管钙化的影响
Sherouk S Shams,Mohamed T Ghoneim,Doaa A Ghareeb et al.
Sherouk S Shams et al.
Vascular calcification (VC) is prevalent in patients with chronic kidney disease and raises the risk of cardiovascular death. The study aimed to evaluate the protective effects of rosuvastatin and/or vitamin K on VC in a rat model of adenin...
Androgen replacement therapy for Torsades de Pointes in males: hormonal modulation as a novel antiarrhythmic strategy [0.03%]
用于男性Torsades de Pointes的雄激素替代疗法：激素调节作为新的抗心律失常策略
Riccardo Accioli,Pier Leopoldo Capecchi,Mohamed Boutjdir et al.
Riccardo Accioli et al.