Melissa officinalis extract attenuates gamma radiation-induced cardiac injury in rats: An integrated bioinformatics and experimental study [0.03%]
Melissa officinalis提取物通过整合生物信息学和实验研究缓解γ射线辐射引起的Sprague Dawley大鼠心脏损伤
Ahmed Hammad,Safaa Ae Abd El Wahab,Salwa Ahmed Lotfi et al.
Ahmed Hammad et al.
The detrimental effect of gamma radiation on cardiac tissue is an intricate problem in the field of nuclear medicine. Therefore, this study aimed to investigate the potential mechanism of Melissa officinalis (MO) against irradiation (IR)-in...
When Three Is a Crowd: The Inflammatory Escalade of Triple ICI-Induced Myocarditis [0.03%]
三联ICI诱导的心肌炎的炎症级联反应
Nigeste Carter,Adolfo G Mauro
Nigeste Carter
Validation of Synthesa AI, a Large Language Model-Based Screening Tool for Systematic Reviews: Results from Nine Pharmacologic Studies [0.03%]
基于合成AI的大语言模型系统评价筛查工具验证研究：九项药理学研究结果
Lefteris Teperikidis,Christos Trampoukis,Kyiakos Polymenakos
Lefteris Teperikidis
Systematic review screening underpins the evidence base for pharmacology and drug development but remains burdensome, error-prone, and resource-intensive. Synthesa AI, a large language model (LLM)-based abstract screening tool, was develope...
Mean Platelet Volume Shows Distinct Patterns Between Mitral and Aortic Valve Replacement Patients but Does Not Predict Anticoagulation Quality in Mechanical Heart Valves [0.03%]
平均血小板体积在二尖瓣和主动脉瓣置换患者中的表现模式不同，但不能预测机械心脏瓣膜的抗凝质量
Veysi Can,Fuat Polat,Ahmet Ferhat Kaya et al.
Veysi Can et al.
Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This study evaluated whether mean platelet volum...
Rivaroxaban safety and adherence in patients with nonvalvular atrial fibrillation: prospective, observational, cohort, postmarketing study [0.03%]
利伐沙班非瓣膜性房颤患者安全性和依从性的评估：一项前瞻性、观察性队列研究
Elnur Smajić,Elmir Jahić,Denis Mršić et al.
Elnur Smajić et al.
The aim of this study was to evaluate real-world rivaroxaban safety and adherence in patients with nonvalvular atrial fibrillation (NVAF). A prospective, observational, cohort, postmarketing study was conducted during a six-month period. Th...
Sonodynamic Therapy Attenuates TLR4/NF-κB Signaling in Epicardial Adipose Tissue of Atrial Fibrillation: Insights from Animal Models, scRNA-seq, and Mendelian Randomization [0.03%]
声动力疗法通过动物模型、单细胞测序和孟德尔随机化研究抑制心外膜脂肪组织中TLR4/NF-κB信号通路以治疗房颤
Penghao Gao,Wei Wang,Weifa Wang et al.
Penghao Gao et al.
Atrial fibrillation (AF) is the most common arrhythmia leading to cardioembolic stroke, with inflammation of epicardial adipose tissue (EAT) contributing to its pathogenesis. However, current therapies cannot specifically target EAT inflamm...
Ling-Gui-Zhu-Gan decoction decreases doxorubicin-induced cardiotoxicity by regulating inflammation via the cGAS-STING pathway [0.03%]
苓桂枝甘汤通过调节cGAS-STING通路介导的炎症减轻阿霉素所致的心脏毒性
Shu-Shu Wang,Ya-Li Yang,Hui-Min Ding et al.
Shu-Shu Wang et al.
Recent evidence has shown that the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway mediated by nuclear factor E2-related factor 2 (Nrf2) contributes to the pathogenesis of doxorubicin (DOX)-induced ca...
Midodrine hydrochloride as a treatment for postural orthostatic tachycardia syndrome: A systematic review and meta-analysis [0.03%]
米多君治疗体位性心动过速综合征的疗效和安全性系统评价和meta分析
Chun Shing Kwok,Soyoung Lee,Azreen Afzal et al.
Chun Shing Kwok et al.
The aim of this review is to evaluate the evidence for midodrine as a treatment for patients with postural orthostatic tachycardia syndrome (POTS). We conducted a systematic review of the literature to identify studies which evaluate midodr...
Human H1 Receptor Antagonism by Imipramine: Bridging Experimental Models and Clinical Cardiotoxicity [0.03%]
阿米替林阻断人H1受体：从实验模型到临床心脏毒性的桥梁研究
Martina Toldo,Jazmin Kelly,Adolfo Gabriele Mauro et al.
Martina Toldo et al.
Efficacy and Safety of the β3-Adrenergic Agonist Mirabegron in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis [0.03%]
β肾上腺素受体激动剂米拉贝隆在心力衰竭患者中应用的有效性和安全性：系统综述和meta分析的更新研究
Alaa Abdelhamid,Ahmed Arabi,Humam Rajha et al.
Alaa Abdelhamid et al.
Heart failure (HF) remains a leading cause of global mortality. β3-adrenergic receptors are upregulated in HF and their activation has demonstrated cardioprotective effects in preclinical studies. This systematic review and meta-analysis e...