Cardioprotective effects of soluble guanylate cyclase and its α1 subunit on myocardial ischemia/reperfusion injury via the PGC-1α/UCP2 pathway [0.03%]
可溶性鸟苷酸环化酶及其α1亚基通过PGC-1α/UCP2信号通路对心肌缺血再灌注损伤的保护作用
Jiao Li,Xinhang Li,Yafang Chen et al.
Jiao Li et al.
This study investigates the cardioprotective potential of soluble guanylate cyclase (sGC) and its α1 subunit in myocardial ischemia/reperfusion (I/R) injury, along with the underlying mechanisms. We used a model involving Sprague Dawley ra...
Commentary On the Effects of Anakinra on Cardiorespiratory Fitness in Heart Failure Stratified by Age in Phase II Clinical Trials [0.03%]
二期临床试验中不同年龄段安卡拉对心力衰竭患者心肺功能影响的评论
Davide Nilo,Francesca Gualdiero,Vincenzo Russo et al.
Davide Nilo et al.
NOX-derived ROS generation drives endothelial-to-mesenchymal transition in human pulmonary endothelial cells exposed to sera from patients with idiopathic pulmonary fibrosis [0.03%]
人特发性肺纤维化患者血清中NOX来源的ROS生成可驱动人肺内皮细胞向间充质细胞转化
Thị Hằng Giang Phan,Anna Maria Posadino,Roberta Giordo et al.
Thị Hằng Giang Phan et al.
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive lung disease marked by extracellular matrix deposition, oxidative stress, and profound microvascular remodeling. Endothelial dysfunction, particularly via endothelial-to-mese...
Time to combinatorial regimens: SGLT2i and PCSK9i in High-Risk Cardio-Oncology Patients [0.03%]
高危心血管肿瘤患者的联合治疗：SGLT2i和PCSK9i的最佳时机
Vincenzo Quagliariello,Massimiliano Berretta,Irma Bisceglia et al.
Vincenzo Quagliariello et al.
Cardiometabolic complications represent a leading cause of morbidity and mortality among cancer survivors, who increasingly face a dual burden of residual oncologic risk and rising cardiovascular vulnerability. The shared pathophysiological...
Anakinra in Fulminant Acute Myocarditis: A Case Report and Review of the Literature [0.03%]
阿那白滞素治疗急进性心肌炎一例及文献复习
Sofia Morini,Simone Filomia,Gianluigi Saponara et al.
Sofia Morini et al.
Fulminant myocarditis (FM) is a critical condition with high mortality. Interleukin-1 (IL-1) is a key mediator of myocardial inflammation. We describe the case of a 19-year-old male with FM, hemodynamic deterioration refractory to standard ...
Fadi N Salloum,Frank J Raucci
Fadi N Salloum
Current challenges for the diagnosis of HFpEF and possible simplification of the diagnostic approach [0.03%]
HFpEF诊断的当前挑战以及简化诊断流程的可能性
Marco Bernardi,Michele Golino,Luigi Spadafora et al.
Marco Bernardi et al.
Heart failure with preserved ejection fraction (HFpEF) is a prevalent and multifaceted clinical syndrome, often underdiagnosed due to its heterogeneous presentation and overlapping comorbidities. Recent randomized trials have demonstrated t...
The Effects of Anakinra on Cardiorespiratory Fitness in Heart Failure Stratified by Age in Phase II Clinical Trials [0.03%]
安卡拉对心力衰竭患者 cardiorespiratory fitness的影响：II 期临床试验按年龄分层分析
Austin C Hogwood,Michele Golino,Francesco Moroni et al.
Austin C Hogwood et al.
Cardiorespiratory fitness (CRF) in heart failure (HF) declines with age. Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging and HF. We aimed to determine the changes in CRF before and after treatment with anakinra, recomb...
CDK Inhibitor R547 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via PI3K/AKT and TGF-β/Smad3 Signaling Pathways [0.03%]
R547通过PI3K/AKT和TGF-β/Smad3信号通路抑制压力超负荷诱导的心脏肥厚
Chenglan Song,Qun Tang,Ling Liu et al.
Chenglan Song et al.
Chronic stress-induced cardiac hypertrophy remains a critical precursor to heart failure, with current therapies limited by incomplete mechanistic targeting. Cyclin-dependent kinases (CDKs), pivotal regulators of cell cycle and stress signa...