Muscle Adverse Events Associated with Inclisiran: Data Mining of FAERS database and Mendelian Randomization Analysis [0.03%]
Inclisiran相关的肌肉不良事件：基于FAERS数据库的数据挖掘和孟德尔随机化分析
Dan Liu,JiFang Liu,Wei Mao et al.
Dan Liu et al.
Inclisiran, the first small interfering RNA (siRNA) lipid lowering drug, has reported muscle adverse events (MAEs), but long-term safety is unclear. This study is based on data obtained from the Food and Drug Administration Adverse Event Re...
Lactylation-Related Gene Signature and Immune Infiltration Crosstalk in Heart Failure: Insights from Bulk and Single-Cell Transcriptomics [0.03%]
心力衰竭中乳酰化相关基因特征与免疫浸润交叉对话：来自批量和单细胞转录组学的见解
Yao Xie,Tieqiu Huang,He Wang et al.
Yao Xie et al.
Heart failure (HF), with varied symptoms caused by cardiac strain or damage, has high morbidity and mortality. Protein lactylation, a post-translational modification, regulates immune and cardiovascular processes, but its role in HF's immun...
Cardiac Remodeling in Preeclampsia: A Large-Language-Model-Assisted Meta-Analysis and Meta-Regression [0.03%]
子痫前期心室重塑的meta分析和Meta回归
Lefteris Teperikidis,Aristi Boulmpou,Ghadir Amin et al.
Lefteris Teperikidis et al.
Preeclampsia is a hypertensive disorder of pregnancy associated with substantial maternal morbidity and long-term cardiovascular risk, but the consistency of echocardiographic remodeling remains unclear. We conducted a mega-meta-analysis of...
A New Era for Cardio-Oncology: Highlights from the Inaugural ESC Cardio-Oncology Congress [0.03%]
心血管肿瘤学的新时代：首次欧洲心脏病学会心血管肿瘤学大会亮点
Luigi Spadafora,Massimiliano Camilli,Svetlana Mosteoru et al.
Luigi Spadafora et al.
Baxdrostat: the new kid on the block for the treatment of resistant hypertension [0.03%]
巴索 drostat：难治性高血压治疗的新秀
Giuseppe Biondi-Zoccai,Antonio Abbate,George W Booz
Giuseppe Biondi-Zoccai
Traditional Chinese Medicine in the Treatment of Diabetic Cardiomyopathy: A Comprehensive Review [0.03%]
糖尿病心肌病的中医治疗研究进展综述
Jia-Xin He,Hai-Tao Xiao,Meng-Meng Du et al.
Jia-Xin He et al.
Diabetic cardiomyopathy (DCM), a global cardiovascular complication of diabetes, is characterized by concurrent diastolic and systolic ventricular dysfunction that progressively leads to heart failure, arrhythmias, and cardiogenic shock. De...
Cardioprotective Effects of Apelin in Myocardial Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis [0.03%]
阿利宁对心肌缺血再灌注损伤保护作用的系统评价和meta分析
Seyedhesamoddin Khatami,Mohammadsadegh Faghihi,Amirali Zarrin et al.
Seyedhesamoddin Khatami et al.
Myocardial ischemia/reperfusion (I/R) injury remains a major clinical challenge, as blood flow restoration can exacerbate tissue damage. Apelin, an endogenous peptide acting via the APJ receptor, has demonstrated cardioprotective effects in...
Disparate mechanical and functional properties of spontaneously hypertensive rat (SHR) and spontaneously hypertensive heart failure (SHHF) rat penetrating arterioles [0.03%]
自发性高血压(SHR)和自发性高血压心脏衰竭(SHFF)大鼠的穿支动脉具有不同的机械性能和功能性质
Crystal Acosta,Hope D Anderson,Christopher M Anderson
Crystal Acosta
Hypertension is associated with significant changes in the vascular system and is an important risk factor for cerebrovascular disease. Moreover, hypertension is a dominant determinant of heart failure, and both contribute to the developmen...
New cardioprotective frontiers in double inhibition with SGLT2 and PCSK9 in cancer survivors [0.03%]
癌症幸存者中SGLT2和PCSK9双重抑制的新心血管保护作用前沿研究
Alexander E Berezin
Alexander E Berezin
PHB1 attenuates triptolide-induced cardiotoxicity by regulating mitochondrial dynamics in cultured newborn mice cardiomyocytes [0.03%]
PHB1通过调节新生小鼠心肌细胞线粒体动力学来减轻三氧茋碱引起的心脏毒性
Wanlin Chen,XinGuo Li
Wanlin Chen
Triptolide (TP) is widely used clinically for multiple diseases, but its cardiotoxicity significantly limits its clinical applications. The underlying mechanisms of its cardiotoxicity are still unclear. Mitochondria are crucial for cellular...