Expert Opinion: Restrictions, Precautions, or Normalcy? Defining Everyday Risk in Patients Treated With IL-1 Blockers for Recurrent Pericarditis [0.03%]
专家观点：限制、预防还是常规？如何界定衣illin抑制剂治疗复发性心包炎患者的日常风险？
Patrick Creechan,Jonathan Salik,Brittany Weber et al.
Patrick Creechan et al.
As the use of interleukin-1 blockers in recurrent pericarditis has increased, questions regarding infection risk, activity restrictions, and lifestyle considerations have increasingly arisen in clinical practice. We describe expert opinion-...
The Therapeutic Role of Exercise in Diabetic Cardiomyopathy: Underlying Mechanisms and Interactions with Antidiabetic Medications [0.03%]
运动在糖尿病心肌病治疗中的作用：潜在机制及其与降糖药物的相互作用
Nabil Deb Nath,Amy Thomas,Jun Yoshioka
Nabil Deb Nath
Diabetes mellitus is an emerging global health concern, with its prevalence rising at an alarming rate. Cardiovascular complications are significantly more pronounced in diabetic individuals, underscoring the urgent need for effective thera...
Cardiovascular Adverse Events Associated with Immune Checkpoint Inhibitors from the Perspective of Gut Microecology: Potential Roles and Research Advances of the Gut Microbiota [0.03%]
免疫检查点抑制剂心血管不良反应与肠道微生态：肠道菌群的潜在作用及研究进展
Zaiyi Chen,Guo Li,Xinyi Tang et al.
Zaiyi Chen et al.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy by significantly improving the prognosis of patients with various malignancies. Despite their clinical benefits, ICIs are increasingly recognized for inducing card...
Silencing Triglycerides: The Clinical Impact of Plozasiran and apoC-III Inhibition in Severe Hypertriglyceridemia [0.03%]
降甘油三酯：PLOZASIRAN和apoC-III抑制在重度高甘油三酯血症中的临床影响
Belal Kassem,Fawaz A Shaik,Omar Sorour et al.
Belal Kassem et al.
Severe hypertriglyceridemia (sHTG) is a critical metabolic disorder that substantially elevates the risk of atherosclerotic vascular disease and acute pancreatitis. Despite its clinical significance, many conventional triglyceride-lowering ...
Ivabradine in Heart Transplant Recipients With Sinus Tachycardia: A Systematic Review and Meta-Analysis [0.03%]
伊伐布雷定治疗心脏移植受者的窦性心动过速：系统评价和meta分析
Khadeeja Ali Hamzah,Yousif Hameed Kurmasha,Waleed Mohaned Rasheed et al.
Khadeeja Ali Hamzah et al.
Sinus tachycardia is common after heart transplantation (HTx) and may worsen graft function via increased oxygen demand and remodeling. Ivabradine, a selective If channel inhibitor, lowers heart rate independently of sympathetic activity. T...
SGLT2 Inhibitors Attenuate Neutrophil-Mediated Endothelial Injury in CAD with T2DM Through a GREM1-Associated Smad Signaling Axis [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂通过GREM1相关Smad信号轴减弱冠状动脉疾病合并2型糖尿病患者中性粒细胞介导的内皮损伤
Wenyuan Zheng,Yixin Zhou,Bozhi Ye et al.
Wenyuan Zheng et al.
Type 2 diabetes mellitus (T2DM) is a critical risk factor for coronary artery disease (CAD), with neutrophils contributing to CAD via acute inflammatory responses. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors offer cardiovascular bene...
Effect of EET-A treatment on Cardiac Hypertrophy Induced by Isoproterenol in Sprague-Dawley Rats [0.03%]
EET-A治疗对异丙肾上腺素诱导的大鼠心室肥厚的影响研究
Sara A Helal,Samar H Gerges,Keshav Gopal et al.
Sara A Helal et al.
Metabolites of arachidonic acid (AA) generated by cytochrome P450 (CYP) enzymes play significant roles in cardiac pathophysiology. Epoxyeicosatrienoic acids (EETs) exert vasodilatory, anti-inflammatory, and cardioprotective effects, but the...
Pitfalls of therapies targeting the nitric oxide signaling pathway in heart failure with preserved ejection fraction [0.03%]
针对射血分数保留的心力衰竭患者靶向一氧化氮信号通路治疗的陷阱
Skylar A Loeb,Darla L Tharp,Scott D Zawieja et al.
Skylar A Loeb et al.
Over 30 million individuals globally are afflicted with heart failure with preserved ejection fraction (HFpEF). Despite this substantial figure, treatment options for HFpEF remain limited. This is largely attributed to the variability in di...
The novelty of anticoagulation in LVAD Therapy: Current Practice, the Role of Direct Oral Anticoagulants, and Future Directions [0.03%]
心室辅助装置治疗中的抗凝新问题：当前实践、新型口服抗凝药的作用及未来方向
Dor Lotan,Boaz Elaz,Changhee Lee et al.
Dor Lotan et al.
Left ventricular assist devices (LVADs) are an established therapy for end-stage heart failure as bridge-to-transplant and destination therapy. Despite advances with fully magnetically levitated devices such as the HeartMate 3, hemocompatib...
Clinical characteristics and outcomes of diuretic resistance identified by diuretic effect trajectory: A retrospective cohort study using the MIMIC IV database [0.03%]
利尿剂抵抗的临床特征和预后：基于MIMIC IV数据库的回顾性队列研究
Wenjing Wu,Sunjie Xu,Yafeng Wu et al.
Wenjing Wu et al.
To identify diuretic resistance (DR) in patients with congestive heart failure (CHF) during intensive care treatment by analyzing the diuretic effect (DE) and to investigate their clinical characteristics and prognosis. Data of 1,744 patien...