The Emerging Role of Artificial Intelligence in Drug Discovery and Development: Implications for Cardiovascular Pharmacology [0.03%]
人工智能在药物发现和开发中的新兴作用及其对心血管药理学的影响
Alaa Abdelhamid,Dima Nasrallah,Yaman Al-Haneedi et al.
Alaa Abdelhamid et al.
Cardiovascular diseases remain the leading cause of global morbidity and mortality, highlighting the urgent need for more efficient, precise, and cost-effective drug development strategies. Traditional drug discovery pipelines face persiste...
Evidence of Cardiotoxic Immune Activation by Triple Immune Checkpoint Blockade: A Translational Alert for Clinical Surveillance in cancer patients [0.03%]
三重免疫检查点阻断引起心毒性免疫活化的证据：癌症患者临床监测的转化研究警讯
Vincenzo Quagliariello,Margherita Passariello,Martina Belardo et al.
Vincenzo Quagliariello et al.
Immune checkpoint inhibitors (ICIs) have successfully revolutionized cancer therapy, but their immune-mediated adverse events include rare, often severe myocarditis. While dual ICI blockade is associated with increased cardiotoxic risk, lit...
Musculoskeletal adverse events associated with bempedoic acid: a real-world pharmacovigilance study [0.03%]
贝美泊苷酸所致肌肉骨骼系统不良反应的药物警戒研究
Yeqian He,Yuqing Wei,Xia Jiang et al.
Yeqian He et al.
Musculoskeletal adverse reactions (MAEs) caused by statins are the main reason that limits their clinical application. Bempedoic acid provides an alternative treatment option for patients who cannot tolerate statins as a novel oral lipid-lo...
Dapagliflozin reduces myocardial injuries through modulation of H3K27me3 and SIRT1 in the male rat model of myocardial ischemia reperfusion [0.03%]
达格列净通过调节H3K27me3和SIRT1减少大鼠心肌缺血再灌注损伤模型中男性的 myocardial injuries
Tina Kianfar,Masoud Fallah,Fatemeh Ramezani et al.
Tina Kianfar et al.
Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, exhibits cardioprotective effects; however, the underlying epigenetic and molecular mechanisms remain poorly understood. This study investigated whether DAPA mitigate...
Protamine for Coronary Perforation in Chronic Total Occlusion Percutaneous Coronary Intervention [0.03%]
慢性完全闭塞冠状动脉介入治疗中鱼精蛋白注射治疗冠状动脉穿孔并发症
Sant Kumar,Sudhir Thotakura,Kathleen E Kearney et al.
Sant Kumar et al.
Protamine is frequently used to reverse unfractionated heparin, yet contemporary data on its safety and long-term outcomes in chronic total occlusion percutaneous coronary intervention (CTO PCI)-related perforation are limited. We retrospec...
Irina Semenycheva,Svetlana Larina,Larisa Zakharova et al.
Irina Semenycheva et al.
This study evaluated the clinical efficacy and safety of repeated levosimendan administration, both as monotherapy and in combination with dapagliflozin, in outpatients with chronic heart failure (CHF) and reduced ejection fraction (
VASCULAR HYPORESPONSIVENESS IN SEPSIS IS ASSOCIATED WITH NITRIC OXIDE-DEPENDENT ACTIVATION OF G-PROTEIN RECEPTOR KINASE 2 [0.03%]
脓毒症血管低反应性与一氧化氮依赖的G蛋白偶联受体激酶2激活相关
Daniela Dal-Secco,Vania C Olivon,Mara R N Celes et al.
Daniela Dal-Secco et al.
Sepsis is a life-threatening condition caused by a dysregulated host response to infection that often leads to profound end organ derangement in which vascular system dysfunction plays a critical role. Septic shock is characterized by a pro...
LC3B, a Protein That Serves as an Autophagic Marker, Modulates Angiotensin II-induced Myocardial Hypertrophy [0.03%]
LC3B通过调节血管紧张素II诱导的心肌肥厚发挥作用
Jionghua Huang,Wei Pan,Dejin Ou et al.
Jionghua Huang et al.
Molecular Mechanisms of Felodipine Suppressing Atherosclerosis in High-Cholesterol-Diet Apolipoprotein E-Knockout Mice: Erratum [0.03%]
氟桂利嗪抑制高胆固醇饮食Apoe基因敲除小鼠动脉粥样硬化分子机制的研究-勘误
Rui Yao,Xiang Cheng,Yu-Hua Liao et al.
Rui Yao et al.
Efficacy and Safety of Oral PCSK9 Inhibitors in Adults with Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [0.03%]
口服PCSK9抑制剂治疗高胆固醇血症成人患者的有效性和安全性：随机对照试验的系统综述和meta分析
Amna Amir Jalal,Syed Ibad Hussain,Erum Siddiqui et al.
Amna Amir Jalal et al.
Injectable PCSK9 inhibitors effectively lower LDL-C levels in patients with hypercholesterolemia; however, their high cost and requirement for parenteral administration limit their widespread use. Oral PCSK9 inhibitors have emerged as a con...