Albumin and Bleeding Risk in Hospitalized Patients Receiving Apixaban [0.03%]
阿哌沙班治疗患者的血浆白蛋白水平与出血风险的关系
Ashley E Woodruff,Shiqi Zhang,Bidoura Chowdhury et al.
Ashley E Woodruff et al.
Highly protein-bound anticoagulants such as warfarin and rivaroxaban have increased therapeutic effects in the setting of hypoalbuminemia due to increased free concentrations in the drug which result in increased bleed risk. Apixaban is als...
Reversal of the Anticoagulant Effect of Milvexian by 4-Factor PCC and rFVIIa in Healthy Participants: a Two-Part, Randomized, Crossover Study [0.03%]
健康参与者中特异性逆转Milvexian抗凝作用的四因子prothrombin复合物浓缩剂和重组活化因子Ⅶ的研究：一项两部分、随机、交叉对照研究
Victor Dishy,Sue Sha,Anastasiya Koshkina et al.
Victor Dishy et al.
Milvexian is a selective, oral factor XIa inhibitor. Individuals receiving anticoagulation may require prompt reversal of anticoagulative effects. This study assessed reversal of milvexian's anticoagulant effects by recombinant human factor...
Ceramide-phospholipid risk score associates with cardiovascular events and is lowered by atorvastatin, simvastatin and anti-PCSK9 treatments [0.03%]
鞘氨醇磷脂风险评分与心血管事件相关，并可通过阿托伐他汀、辛伐他汀和抗PCSK9药物治疗降低
Mika Hilvo,Angelika Witoslawska,Mitja Lääperi et al.
Mika Hilvo et al.
The aim of the study was to investigate the prognostic value of previously established ceramide-phospholipid risk score, CERT2, and its response to lipid-lowering treatments in patients with symptomatic or suspected coronary heart disease. ...
Prophylactic ACE inhibition in anthracycline-induced cardiotoxicity: signal, context, and clinical uncertainty [0.03%]
蒽环类药物所致心脏毒性的预防性ACE抑制：信号、背景和临床不确定性
Beatrice Simeone,Erica Rocco,Luigi Spadafora et al.
Beatrice Simeone et al.
Anthracyclines remain a cornerstone of cancer therapy but are associated with a spectrum of cardiovascular toxicity, ranging from subclinical myocardial injury to overt heart failure (HF). Despite strong biological rationale, the role of un...
Thanh Hoai Pham,Britt Hofmann,Jonas M A Schlicht et al.
Thanh Hoai Pham et al.
Imipramine was one of the first antidepressant drugs that entered the clinic and is still used to this day. The antidepressant action of imipramine is, at least in part, due to an inhibition of noradrenaline and serotonin transport in the b...
Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis [0.03%]
伊伐布雷定在新冠肺炎大流行前后的POTS治疗中的应用：系统评价和Meta分析
Syeda Hafsa Qadri,Ana Beatriz Nardelli da Silva,Andela Malaj et al.
Syeda Hafsa Qadri et al.
Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide i...
The Cardiac Sarcomere: From development of heritable cardiomyopathies to gene and precision therapies [0.03%]
心脏肌小节：从遗传性心肌病的发病机制到基因及精准治疗
Yun Shi,Brittany N Balint,Paula F Nieto Morales et al.
Yun Shi et al.
The cardiac sarcomere forms the fundamental contractile unit of the myocardium, and its precise structural and regulatory integrity is essential for normal cardiac function. Over the past several decades, advances in functional and structur...
Efficacy and Safety of Lorundrostat for Uncontrolled and Treatment-resistant Hypertension: A Systematic Review and Meta-analysis of Randomized Controlled Trials [0.03%]
洛伦多司特治疗难治性高血压有效性和安全性的系统评价和meta分析
Zain Ul Abideen,Muhammad Hassan Waseem,Areeba Shoaib et al.
Zain Ul Abideen et al.
Uncontrolled hypertension remains a major contributor to cardiovascular morbidity and mortality. Lorundrostat directly reduces aldosterone synthesis and represents a targeted therapeutic strategy. This study aimed to evaluate the comparativ...
Safety and Efficacy of Lorundrostat in Uncontrolled Hypertension: A Systematic Review and Meta-Analysis [0.03%]
洛 fundingRound 肇治疗难治性高血压的安全性和有效性的系统评价和meta分析
Saad Ashraf,Shariq Ahmad Wani,Muhammad Burhan et al.
Saad Ashraf et al.
Uncontrolled hypertension remains a major global health concern and a leading cause of cardiovascular morbidity and mortality. Aldosterone dysregulation plays a critical role in resistant hypertension, and Lorundrostat, a novel aldosterone ...