Observation of the therapeutic effect of dapagliflozin on atherosclerosis in mice and preliminary exploration of the mechanism of action [0.03%]
达格列净对小鼠动脉粥样硬化治疗作用的观察及机制初步探索
Fangfang Chen,Xu Wang,Yang Ma et al.
Fangfang Chen et al.
In recent years, the incidence of Atherosclerosis (AS) has been increasing and has gradually become a major disease threatening human health. In this study, we analyzed the effect of dapagliflozin on AS and preliminarily explore the mechani...
Flavin adenine dinucleotide ameliorates pressure overload-induced heart failure by activating the short-chain acyl-CoA dehydrogenase [0.03%]
核黄素腺嘌呤二核苷酸通过激活短链酰基辅酶a脱氢酶缓解压力超负荷诱导的心力衰竭
Chunyu Chen,Xue Qin,Yuhong Cao et al.
Chunyu Chen et al.
Flavin adenine dinucleotide (FAD), a cofactor that catalyzes the reaction of flavin protein, participates in fatty acid β-oxidation, which has been shown to inhibit pathological cardiac hypertrophy and fibrosis in spontaneously hypertensiv...
Factor XI as a Drug Target for the Prevention and Treatment of Thrombosis [0.03%]
因子XI作为预防和治疗血栓形成的药物靶点
Nathaniel B Wayne,Sarah B Schaidle,Craig J Beavers
Nathaniel B Wayne
The optimal anticoagulation therapeutic intervention balances preventing or treating thrombosis, depending on the clinical scenario, and bleeding. A novel drug target, factor eleven (FXI), may theoretically represent a way to prevent thromb...
Roxadustat has beneficial effects on the vascular tone of the rat thoracic aorta [0.03%]
罗沙司他在大鼠胸主动脉血管张力方面的积极作用
Keisuke Nakagawa,Yoriko Oshiba,Reo Sukita et al.
Keisuke Nakagawa et al.
Roxadustat, an agent for renal anemia, may have beneficial effects on the cardiovascular system, but its direct effects on the vasculature system have not been clarified. Therefore, in this study, the effect of roxadustat on vascular tone w...
Changes for 2025 at Journal of Cardiovascular Pharmacology: Introducing Our Junior Associate Editors, Podcasts, Feature, and New Board Members [0.03%]
心血管药理学杂志2025年变革：介绍我们的青年副主编、播客、特色文章和新董事会成员
Antonio Abbate,Giuseppe Biondi-Zoccai,Raffaele Altara et al.
Antonio Abbate et al.
Cinnamaldehyde attenuates diabetic cardiomyopathy by ameliorating energy metabolism disturbance and activating autophagy [0.03%]
肉桂醛通过改善能量代谢紊乱和激活自噬来减轻糖尿病心肌病
Ming-Qiao Hu,Ke-Zhao Wei,Shi-Yu Wu et al.
Ming-Qiao Hu et al.
Diabetic Cardiomyopathy (DCM) is a diabetes mellitus-induced pathophysiological condition that can lead to heart failure. Cinnamaldehyde (CA), a bioactive phytochemical derived from the bark of Cinnamon, exhibits cardioprotective properties...
ABCB1 gene single nucleotide variants and haplotypes in atrial fibrillation patients experiencing adverse events on direct oral anticoagulation: a whole gene exome sequencing study [0.03%]
心房颤动患者在直接口服抗凝中的不良事件与ABCB1基因单核苷酸变异和杂合子：全基因外显子测序研究
Matej Samoš,Mária Škereňová,Vladimír Nosáľ et al.
Matej Samoš et al.
Single-nucleotide variants (SNVs) of ABCB1 gene encoding glycoprotein P might be connected with increased or decreased levels of direct oral anticoagulants (DOAC), and therefore with DOAC-related adverse bleeding or embolism. The aim of thi...
Trimethylamine N-oxide Aggravates Thoracic Aortic Aneurysm by Inhibiting Axl to Promote Vascular Smooth Muscle Cell Dysfunction [0.03%]
三甲胺-N-氧化物通过抑制Axl促进血管平滑肌细胞功能障碍从而加重胸主动脉瘤
Shuai Leng,Zhiqiao Dang,Shishan Xue et al.
Shuai Leng et al.
Thoracic aortic aneurysm (TAA) is a life-threatening condition that currently lacks an effective therapeutic strategy. Phenotypic switching in vascular smooth muscle cells (VSMCs) and extracellular matrix (ECM) degradation are considered to...
A Multifaceted Intervention to Mitigate the Adverse Cardiovascular Effects of Air Pollution: A Feasibility Randomized Controlled Trial [0.03%]
减轻空气污染对心血管的不良影响的综合性干预方法：一项可行性随机对照试验
Parham Sadeghipour,Azita H Talasaz,Sina Rashedi et al.
Parham Sadeghipour et al.
Air pollution is associated with excess thrombotic and cardiovascular events. However, clinical outcomes trials evaluating interventions to mitigate such adverse events in patients with atherosclerotic cardiovascular diseases (ASCVD) are la...