Impact of Continuous P2Y12 Inhibition Tailoring in Acute Coronary Syndrome and Genetically Impaired Clopidogrel Absorption [0.03%]
急性冠脉综合征中连续P2Y12抑制调整对于基因型对氯吡格雷吸收不良的影响
Jure Samardzic,Nada Bozina,Bosko Skoric et al.
Jure Samardzic et al.
Clopidogrel is still widely used in acute coronary syndrome despite the development of more potent P2Y12 inhibitors. Previously, we conducted a trial that evaluated serial clopidogrel dose adjustment based on platelet function testing in ac...
Essential Role of the ELABELA-APJ Signaling Pathway in Cardiovascular System Development and Diseases [0.03%]
ELABELA-APJ信号通路在心血管系统发育和疾病中起重要作用
Shuang Zhou,Jian Wang,Qingjie Wang et al.
Shuang Zhou et al.
ELABELA (ELA), previously classified as a "noncoding" RNA, is a new endogenous peptidic ligand of apelin receptor (APJ/APLNR), a class A (rhodopsin-like) G protein-coupled receptor. It has been identified to play a crucial role in diverse b...
Experience in Transitioning From Parenteral Prostacyclins to Selexipag in Pulmonary Arterial Hypertension [0.03%]
从静脉前列环素过渡到口服塞利齐帕治疗肺动脉高压的初体验
Kishan S Parikh,Sean Doerfler,Nicholas Shelburne et al.
Kishan S Parikh et al.
Parenteral prostacyclin therapies remain first-line therapy for patients with pulmonary arterial hypertension (PAH) with class IV symptoms. In selected patients who have been clinically stabilized, switching to selexipag, a chemically disti...
Observational Study
Journal of cardiovascular pharmacology. 2020 Apr;75(4):299-304. DOI:10.1097/FJC.0000000000000800 2020
The Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript-1 Regulates CCDC80 Expression by Targeting miR-141-3p/miR-200a-3p in Vascular Smooth Muscle Cells [0.03%]
长非编码RNA转移相关肺腺癌转录本1通过靶向miR-141-3P / miR-200A-3P调节血管平滑肌细胞中CCDC80的表达
Duo Gong,Zhen-Wang Zhao,Qiang Zhang et al.
Duo Gong et al.
Objective: Our previous study showed that Coiled-Coil Domain Containing 80 (CCDC80) accelerates the development of atherosclerosis by decreasing lipoprotein lipase (LPL) expression and activity in apoE knockout mice. Howe...
Cardiovascular Risk and Safety Evaluation of a Dual Peroxisome Proliferator-Activated Receptor-Alpha/Gamma Agonist, Aleglitazar, in Patients With Type 2 Diabetes: A Meta-analysis [0.03%]
阿格列汀扎治疗2型糖尿病患者的心血管风险和安全性评估：系统性评价和 meta 分析
Chun-Liu Han,Chang-Zhi Qu
Chun-Liu Han
This study evaluates the cardiovascular risk and safety of a dual peroxisome proliferator-activated receptor alpha and gamma (PPARα&γ), aleglitazar, for the management of type 2 diabetes mellitus. Studies were identified after a literatur...
Direct Oral Anticoagulants and Coronary Artery Disease: The Debacle of the Aspirin Era? [0.03%]
直接口服抗凝剂与冠心病：阿司匹林时代末世的开端？
Álvaro García-Ropero,Ariana P Vargas-Delgado,Carlos G Santos-Gallego et al.
Álvaro García-Ropero et al.
Long-standing aspirin is the cornerstone to prevent recurrence of thrombotic events in patients with ischemic heart disease. However, clopidogrel, a more potent antiplatelet agent, is preferred over aspirin in targeted populations, includin...
Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway [0.03%]
巴马汀通过抑制活化蛋白1活性及激活Nrf2/HO-1信号通路抑制巨噬细胞泡沫化的形成
Xue-Juan Yang,Fang Liu,Na Feng et al.
Xue-Juan Yang et al.
Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key...
Important Roles of Endothelium-Dependent Hyperpolarization in Coronary Microcirculation and Cardiac Diastolic Function in Mice [0.03%]
小鼠冠状微血管内皮细胞依赖性高内钾血症对心脏舒张功能的重要作用
Yosuke Ikumi,Takashi Shiroto,Shigeo Godo et al.
Yosuke Ikumi et al.
Endothelium-dependent hyperpolarization (EDH) factor is one of endothelium-derived relaxing factors and plays important roles especially in microvessels. We have previously demonstrated that endothelium-derived hydrogen peroxide (H2O2) is a...
Dongchen Zhou,Kun Yang,Jingjing Hu et al.
Dongchen Zhou et al.
Atrial fibrillation (AF) is an important cause of cardiovascular morbidity and mortality. Current therapies for AF are ineffective, mainly due to incomplete understanding of the pathogenesis of AF. Atrial remodeling contributes to the occur...
Protective Effect of Epigallocatechin Gallate on Endothelial Disorders in Atherosclerosis [0.03%]
表没食子儿茶素没食子酸酯对动脉粥样硬化血管内皮损伤的保护作用
Kazuo Yamagata
Kazuo Yamagata
Healthy vascular endothelial cells regulate vascular tone and permeability, prevent vessel wall inflammation, enhance thromboresistance, and contribute to general vascular health. Furthermore, they perform important functions including the ...