Predictors of Statin Intolerance in Patients With a New Diagnosis of Atherosclerotic Cardiovascular Disease Within a Large Integrated Health Care Institution: The IMPRES Study [0.03%]
IMPRES研究中某大型综合医疗体系内动脉粥样硬化性心血管病新诊断患者他汀不耐受的影响因素分析
Tami L Bair,Heidi T May,Kirk U Knowlton et al.
Tami L Bair et al.
Statins are among the most prescribed medications because of the well-documented benefits of safely lowering low-density lipoprotein cholesterol. However, many patients are unable or unwilling to continue statin therapy because of real or p...
Case-Control Study on the Interaction Effects of rs10757278 Polymorphisms at 9p21 Locus and Traditional Risk Factors on Coronary Heart Disease in Xinjiang, China [0.03%]
中国新疆汉族人群9p21位点rs10757278多态性与传统危险因素交互作用影响冠心病的病例对照研究
Wu-Hong Lu,Wen-Qian Zhang,Yun-Juan Zhao et al.
Wu-Hong Lu et al.
Objective: To study the interaction effects of rs10757278 polymorphisms at 9p21 locus and traditional risk factors on coronary heart disease (CHD) in Xinjiang, China. ...
New Frontiers for an Old Drug: What Is New on the Pleiotropic Effect of Sulodexide in Chronic Venous Disease [0.03%]
旧药新域：慢性静脉疾病单硫酸氨聚糖肝素联合制剂的多效性作用的新进展
Daniela Ligi,Rosanna Maniscalco,Ferdinando Mannello
Daniela Ligi
Monitoring Antiplatelet Aggregation In Vivo and In Vitro by Microtiter Plate Method [0.03%]
利用酶联免疫方法监测抗血小板聚集药物的体内、体外药效学研究
Qiu-Ling Wu,Jun Dong,Hua-Wu Zeng et al.
Qiu-Ling Wu et al.
Background: The current light transmission aggregation method is a recognized conventional method for platelet function evaluation, but it is time-consuming and poor in parallelism and cannot simultaneously monitor multip...
Cardiac cGMP Signaling in Health and Disease: Location, Location, Location [0.03%]
心肌cGMP信号在健康和疾病中的作用：位置，位置，位置
Friederike Cuello,Viacheslav O Nikolaev
Friederike Cuello
3',5'-Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger, which critically regulates cardiac pump function and protects from the development of cardiac hypertrophy by acting in various subcellular microdomains. Although ...
Mitochondrial Translocation of DJ-1 Is Mediated by Grp75: Implication in Cardioprotection of Resveratrol Against Hypoxia/Reoxygenation-Induced Oxidative Stress [0.03%]
Gstα介导的Parkin向线粒体的易位在白藜芦醇通过自噬保护心肌缺血再灌注损伤中的作用及其机制研究
Ting-Ting Zhou,Xue-Ying Wang,Jiao Huang et al.
Ting-Ting Zhou et al.
Resveratrol (Res) was recently reported to ameliorate hypoxia/reoxygenation (H/R)-caused oxidative stress in H9c2 cardiomyocytes through promoting the mitochondrial translocation of DJ-1 protein and subsequently preserving the activity of m...
Pulmonary Delivery of Antiarrhythmic Drugs for Rapid Conversion of New-Onset Atrial Fibrillation [0.03%]
用于快速治疗新发作房颤的抗心律失常药物肺部给药研究
Richard L Verrier,Luiz Belardinelli
Richard L Verrier
Pharmacologic management of atrial fibrillation (AF) is a pressing problem. This arrhythmia afflicts >5 million individuals in the United States and prevalence is estimated to rise to 12 million by 2050. Although the pill-in-the-pocket regi...
Jesus Hernandez-Juarez,Hugo Guillermo Espejo-Godinez,Rodrigo Mancilla-Padilla et al.
Jesus Hernandez-Juarez et al.
Rivaroxaban is a direct oral anti-factor Xa anticoagulant. It has recently been suggested that rivaroxaban may affect platelet function in vitro; however, little is known about the clinical impact of this likely antiplatelet effect and whet...
Impact of Continuous P2Y12 Inhibition Tailoring in Acute Coronary Syndrome and Genetically Impaired Clopidogrel Absorption [0.03%]
急性冠脉综合征中连续P2Y12抑制调整对于基因型对氯吡格雷吸收不良的影响
Jure Samardzic,Nada Bozina,Bosko Skoric et al.
Jure Samardzic et al.
Clopidogrel is still widely used in acute coronary syndrome despite the development of more potent P2Y12 inhibitors. Previously, we conducted a trial that evaluated serial clopidogrel dose adjustment based on platelet function testing in ac...
Essential Role of the ELABELA-APJ Signaling Pathway in Cardiovascular System Development and Diseases [0.03%]
ELABELA-APJ信号通路在心血管系统发育和疾病中起重要作用
Shuang Zhou,Jian Wang,Qingjie Wang et al.
Shuang Zhou et al.
ELABELA (ELA), previously classified as a "noncoding" RNA, is a new endogenous peptidic ligand of apelin receptor (APJ/APLNR), a class A (rhodopsin-like) G protein-coupled receptor. It has been identified to play a crucial role in diverse b...