Comparative Efficacy of Non-Statin Lipid-Lowering Therapies in Patients With Hypercholesterolemia at Increased Cardiovascular Risk: An Updated Network Meta-Analysis [0.03%]
他汀类以外的降脂疗法治疗高胆固醇血症合并心血管病患者疗效比较：网状meta分析的更新研究
Heather Burnett,Allie Cichewicz,Harshul Natani et al.
Heather Burnett et al.
Hypercholesterolemia is associated with atherosclerotic cardiovascular disease (ASCVD), a leading cause of morbidity and mortality. Non-statin lipid-lowering therapies (LLTs) such as ezetimibe, proprotein convertase subtilisin/kexin type 9 ...
Dihydrotestosterone Pretreatment Diminishes the Severity of Drug-Induced Torsades de Pointes [0.03%]
雄烯二醇的预处理可减轻药物所致尖端扭转型室速的严重程度
James E Tisdale,Heather A Jaynes,Brian R Overholser et al.
James E Tisdale et al.
Testosterone and dihydrotestosterone (DHT) attenuate drug-induced lengthening of ventricular repolarization, but it is unknown whether they influence drug-induced torsades de pointes (TdP). We tested the hypothesis that DHT reduces the inci...
Cuijuan Zhang,Zhihang Du,Rui Chen et al.
Cuijuan Zhang et al.
Cardiovascular disease (CVD) is one of the leading causes of mortality in humans, with a high prevalence. Moreover, this disease poses a serious threat to the economy. At present, treatment strategies are inadequate in both the prevention a...
Heart Rate Lowering with Ivabradine and Burden of Symptoms in Patients with Postural Orthostatic Tachycardia Syndrome [0.03%]
伊伐布雷定降低体位性心动过速综合征患者心率及其症状负担的影响
Michele Marchetta,Rocio I Lopez,Austin C Hogwood et al.
Michele Marchetta et al.
Postural Orthostatic Tachycardia Syndrome (POTS) is a clinical syndrome of tachycardia upon standing leading to palpitations, dizziness, chest pain and/or fatigue. An exaggerated norepinephrine response with standing is often present in POT...
Oltipraz ameliorates pressure overload-induced pathological cardiac hypertrophy in mice [0.03%]
烯丙雌酚缓解小鼠压力超负荷诱导的病理性心脏肥厚
Junmou Hong,Huang Cao,Yan Wang
Junmou Hong
Oltipraz (OPZ), a synthetic dithiothiol, is regarded as a novel agonist of nuclear factor erythroid-2 (Nrf-2). Recent studies revealed that Nrf-2 activation could suppress the pathological cardiac hypertrophy in mice. However, the therapeut...
COLCHICINE IN ACUTE CORONARY SYNDROMES: A META-ANALYSIS OF 12.602 PATIENTS [0.03%]
科赫氏素对急性冠脉综合征影响的 meta 分析：共 12602 例患者的系统评价
Luigi Cappannoli,Francesco Fracassi,Cristina Aurigemma et al.
Luigi Cappannoli et al.
Inflammation is a leading cause of ischaemic heart disease. Aim of the present study is to assess whether treatment with colchicine in patients with ACS is associated with improved cardiovascular outcomes. We conducted a systematic review a...
Contemporary Analysis of cardiac Tamponade Etiologies, Treatments, and Outcomes: the CATEO Study [0.03%]
当代心包填塞病因、治疗和预后的分析：CATEO研究
Marco Giuseppe Del Buono,Mattia Brecciaroli,Gianluigi Saponara et al.
Marco Giuseppe Del Buono et al.
Cardiac tamponade is a critical condition resulting from various etiologies, including malignancies, inflammatory conditions and iatrogenic causes. With advances in treatments and changing epidemiology, there is a need to reassess the preva...
Role of Muscarinic Acetylcholine Receptors in Oxytocin-Induced Cardioprotection Against Ischemia-Reperfusion Injury in Rats [0.03%]
muscarinic受体在 oxytocin抗大鼠心肌缺血再灌注损伤中的作用
Mahdieh Faghihi,Mohammadreza Ahmadi-Beni,Fariba Houshmand
Mahdieh Faghihi
Oxytocin (OT) has been shown to provide myocardial protection against ischemia-reperfusion (I/R) injury. This study investigates the involvement of muscarinic receptors in the OT-induced cardioprotection, focusing on its potential mechanism...
Aprocitentan for Treatment-Resistant Hypertension: Pharmacology Concepts and Clinical Insights [0.03%]
用于难治性高血压的治疗药物Aprocitentan：药理学概念和临床见解
Apryl N Peddi,Sarah E Wheeler,Keerthana Akkisetty et al.
Apryl N Peddi et al.
Treatment resistant hypertension (TRH) occurs in nearly 20% of patients with a diagnosis of hypertension despite receiving three or more antihypertensives and places individuals at an increased risk of morbidity and mortality compared to es...