Development of a Deep Learning Tool to Support the Assessment of Thyroid Follicular Cell Hypertrophy in the Rat [0.03%]
大鼠甲状腺滤泡细胞肥大的深度学习评估工具的开发
Stuart W Naylor,Elizabeth F McInnes,James Alibhai et al.
Stuart W Naylor et al.
Thyroid tissue is sensitive to the effects of endocrine disrupting substances, and this represents a significant health concern. Histopathological analysis of tissue sections of the rat thyroid gland remains the gold standard for the evalua...
Immunohistochemistry-Free Enhanced Histopathology of the Rat Spleen Using Deep Learning [0.03%]
基于深度学习的免疫组化-free的大鼠脾脏增强病理学检测技术研究
Shima Mehrvar,Kevin Maisonave,Wayne Buck et al.
Shima Mehrvar et al.
Enhanced histopathology of the immune system uses a precise, compartment-specific, and semi-quantitative evaluation of lymphoid organs in toxicology studies. The assessment of lymphocyte populations in tissues is subject to sampling variabi...
Pathology Findings and In-Life Correlates in the Nonclinical Development of Adeno-Associated Virus (AAV)-Based Retinal Gene Therapies [0.03%]
基于腺相关病毒(AAV)的视网膜基因治疗非临床开发中的病理学发现及在体相关性研究结果
Helen S Booler,Typhaine Lejeune,Oliver Turner et al.
Helen S Booler et al.
Adeno-associated virus (AAV)-based vectors are the most frequently used platform for retinal gene therapy. Initially explored for the treatment of loss-of-function mutations underpinning many inherited retinal diseases, AAV-based ocular gen...
Trends and Challenges of the Modern Pathology Laboratory for Biopharmaceutical Research Excellence [0.03%]
生物制药研究卓越的现代病理实验室趋势与挑战
Sílvia Sisó,Anoop Murthy Kavirayani,Suzana Couto et al.
Sílvia Sisó et al.
Pathology, a fundamental discipline that bridges basic scientific discovery to the clinic, is integral to successful drug development. Intrinsically multimodal and multidimensional, anatomic pathology continues to be empowered by advancemen...
Neuropathological Findings in Nonclinical Species Following Administration of Adeno-Associated Virus (AAV)-Based Gene Therapy Vectors [0.03%]
腺相关病毒（AAV）基因治疗载体给药后非临床物种神经病理学发现
Brad Bolon,Elizabeth Buza,Elizabeth Galbreath et al.
Brad Bolon et al.
Adeno-associated virus (AAV) gene therapy vectors are an accepted platform for treating severe neurological diseases. Test article (TA)-related and procedure-related neuropathological effects following administration of AAV-based vectors ar...
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution [0.03%]
基于细胞分布的质谱成像区分胆道毒物
Junhai Yang,Andrew P Bowman,Wayne R Buck et al.
Junhai Yang et al.
Mass spectrometry imaging (MSI) was used to investigate and provide insights into observed biliary pathology found in dogs and rats after administration of two different compounds. Both compounds were associated with peribiliary inflammator...
IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research [0.03%]
IHI VICT3R：在毒理学研究中开发和实施虚拟控制组以减少动物使用
Thomas Steger-Hartmann,Ferran Sanz,Frank Bringezu et al.
Thomas Steger-Hartmann et al.
The virtual control group (VCG) concept was originally developed in the IMI2 project eTRANSAFE, using data of control animals which pharmaceutical companies have accrued over decades from animal toxicity studies. This control data could be ...
Kiran Palyada,Renee Hukkanen,Stephanie Leuenroth-Quinn et al.
Kiran Palyada et al.
The so-called undruggable space is an exciting area of potential growth for drug development. Undruggable proteins are defined as those unable to be targeted via conventional small molecule drugs. New modalities are being developed to poten...
Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium [0.03%]
2024年转化毒理学分会卫星 symposium 论文集
Erin M Quist,Shambhunath Choudhary,Typhaine Lejeune et al.
Erin M Quist et al.
The 2024 annual Division of Translational Toxicology (DTT) Satellite Symposium, entitled "Pathology Potpourri," was held in Baltimore, Maryland, at the Society of Toxicologic Pathology's 42nd annual meeting. The goal of this symposium was t...