Jonathan Carter,Kendall Frazier,Jonathan Werner et al.
Jonathan Carter et al.
Comparison of Standard Clinical Pathology Parameter Values in Fasted and Fed Rats and Non-human Primates [0.03%]
空腹与饲喂状态大鼠和非人灵长类动物标准临床病理参数值的比较研究
Larissa Kipa,Tiffany N Scott,Steve Denham et al.
Larissa Kipa et al.
The impact of non-fasting on clinical pathology parameters in pharmacologic safety assessment has been incompletely characterized. The aim of this study was to characterize changes in hematology, coagulation, and clinical chemistry paramete...
Time-Dependent Autolysis in Ex Vivo-Maintained Rat Tissue in Saline: A Descriptive Study and Practical Guidance for Histopathologic Assessment [0.03%]
生理盐水中大鼠组织离体自溶的时效性描述性研究及病理评估实用指导
Zhuang Qian,Jie Meng,Liping Wei et al.
Zhuang Qian et al.
Timely tissue fixation is critical to prevent autolysis, which confounds histopathologic assessment. This study systematically mapped autolysis progression in ex vivo rat tissues under room temperature and refrigerated (4°C) storage condit...
Frederic Schorsch,Mirjam Luijten,Mark Cronin et al.
Frederic Schorsch et al.
The second session of the 2nd Joint BSTP/ESTP Toxicologic Pathology Congress, Manchester, UK, September 23-26, 2025, entitled "New Approach Methodologies for Carcinogenicity Evaluation," was dedicated to innovative strategies for assessing ...
2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology [0.03%]
2025国际毒理病理学会(IATP)卫星研讨会：毒理病理学病理工作小组(PWGs)
Douglas C Wolf,Alys Bradley,Maurice Cary et al.
Douglas C Wolf et al.
The International Academy of Toxicologic Pathology (IATP) Satellite Symposium on Pathology Working Groups (PWGs) in Toxicologic Pathology, organized in the United Kingdom, addressed the value and importance of PWGs and expert working groups...
Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations [0.03%]
毒理病理学论坛*：人工智能在非临床毒理病理学评价中应用的机会与挑战
Thomas Forest,Gordon K Wollenberg,Jerrold M Ward et al.
Thomas Forest et al.
Emily K Meseck,Paul Batty,Tae-Won Kim et al.
Emily K Meseck et al.
Emerging modalities in drug development including adeno-associated virus (AAV) and other viral-mediated gene therapy, targeted protein degraders, oligonucleotide, and chimeric antigen receptor-T cell (CAR-T) therapies require updated approa...
Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue [0.03%]
英国毒理病理学会和欧洲毒理病理学会第二届联合年会专题研讨会
Jonathan Carter,Ute Bach,Zuhal Dincer et al.
Jonathan Carter et al.
Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice [0.03%]
尿烷诱导TgrasH2小鼠胸骨肋间棕色脂肪组织血管肉瘤发生
Maodong Zhang,Predrag Novakovic,Joseph Younan et al.
Maodong Zhang et al.
Urethane has been used as a positive control material for carcinogenicity studies in the TgrasH2 mouse that is a valuable model in pre-clinical safety investigations. This article describes the incidence of hemangiosarcomas (HSAs) in the in...