Calculating Veterinary Clinical Pathology Reference Intervals for Research at the Integrated Research Facility, NIAID: A Practical Application of Data Partitioning and Statistical Methodology [0.03%]
美国NIAID综合研究设施的兽医临床病理参考区间计算研究——数据分区和统计方法的实际应用
Daniel B Woodburn,Jeremy J Bearss,Camille M Lake et al.
Daniel B Woodburn et al.
The veterinary research community requires statistically robust reference intervals in which to contextualize the results of laboratory tests obtained in research studies. While published reference intervals are available for veterinary cli...
Histopathologic Findings in the Heart Associated With Telemetry Instrumentation in Beagle Dogs [0.03%]
与监测仪器相关的Beagle犬心脏组织病理学发现
Rebecca Kohnken,Amanda Wilsey,Brandan Bird et al.
Rebecca Kohnken et al.
Conscious telemetry-instrumented dogs are used during cardiovascular safety assessment in early drug development for the collection of cardiovascular function parameters such as electrocardiography (ECG), heart rate, mean arterial pressure,...
Intrahepatic Cholangiocarcinoma With Pulmonary Metastasis in a Rhesus Macaque (Macaca mulatta) [0.03%]
恒河猴（猕猴）肝内胆管癌伴肺转移
Andressa Varella Gonsioroski,Mayra Tsoi,Meredith Leigh Cronin et al.
Andressa Varella Gonsioroski et al.
A 28-year-old, female Rhesus macaque (Macaca mulatta) was lethargic and inappetent despite supportive treatment. Euthanasia was elected. Necropsy revealed numerous nodules in the liver and lung. Microscopically, the liver and lung were mult...
Rare Occurrence of an Acute Myeloid Leukemia in a Cynomolgus Macaque (Macaca fascicularis) [0.03%]
一只 cynomolgus macaque（猕猴）患急性髓系白血病的罕见病例报告
Heather Priest,Julie Schwartz,Angela Wilcox et al.
Heather Priest et al.
This report presents the findings of a spontaneous case of acute myeloid leukemia (AML) in a 6-year-old male cynomolgus macaque enrolled in a 9-month repeat dose-toxicity and toxicokinetic study. Abnormal hematology findings occurred approx...
Evaluation of Biomarkers to Detect Early Prothrombotic Imbalance in Rat Models of Hypercoagulability Induced by Thromboplastin Infusion and Hypofibrinolysis Induced by Tranexamic Acid [0.03%]
评估纤溶酶原激活物抑制剂-1和血栓调节蛋白作为检测由组织因子和氨甲环酸诱导的实验动物模型早期促凝状态生物标志物的能力
Marjory B Brooks,Cindy E Fishman,Mohanapriya Kamalakannan et al.
Marjory B Brooks et al.
Thrombotic complications including myocardial infarction, stroke, venous thrombosis and pulmonary thromboembolism are common causes of drug attrition often discovered at late stages of drug development. Current nonclinical safety assessment...
Deep Learning Methodology for Quantification of Normal Pancreas Structures [0.03%]
深度学习方法在正常胰腺结构量化中的应用
Zhiyong Xie,Stephane Thibault,Norimitsu Shirai et al.
Zhiyong Xie et al.
Histopathologic evaluation plays a crucial role in assessing morphological tissue alterations in disease models and toxicology studies. Identifying small quantitative shifts in specific substructures of organs can be challenging due to the ...
Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology-The Current State, Challenges, and Future Directions [0.03%]
数字病理学与人工智能在非临床毒理病理中的应用-现状、挑战及未来方向
Gabriele Pohlmeyer-Esch,Charles Halsey,Julie Boisclair et al.
Gabriele Pohlmeyer-Esch et al.
Advancements in digital pathology and artificial intelligence (AI) have enormous transformative potential for nonclinical toxicologic pathology and are already changing the ways in which pathologists work. However, due to the rapid evolutio...
Neuromethods: Basic Techniques for Evaluating the Nervous System in Nonclinical Studies [0.03%]
神经方法：评估非临床研究中神经系统的基本技术
Deepa B Rao,Xavier Palazzi,Alexandra Duetting et al.
Deepa B Rao et al.
The first session of the 2025 European Society of Toxicologic Pathology (ESTP) Congress reviewed routine and specialized methods for microscopic evaluation of neural tissues during nonclinical studies. Three longer presentations reviewed br...
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies [0.03%]
毒理病理论坛：解剖和临床病理数据的统计显著性结果在非临床安全性研究中的解读意见
Lila Ramaiah,Tara Arndt,Gareth Thomas et al.
Lila Ramaiah et al.
Toxicologic pathologists assess large data sets from nonclinical studies to identify treatment-related effects to assist in predicting human safety hazards. Statistical testing can facilitate data interpretation by highlighting group differ...
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies [0.03%]
毒理病理论坛*：关于在非临床毒性研究中表达临床病理终点改变量的定性严重度描述符的意见
N K Tripathi,L Ramaiah,T Arndt et al.
N K Tripathi et al.
Clinical pathology endpoints are routinely assessed in nonclinical toxicity studies and the magnitude of test article-related changes is frequently expressed using quantitative and/or qualitative severity descriptors. Quantitative descripto...