European Society of Toxicologic Pathology-Pathology 2.0 Mass Spectrometry Imaging Special Interest Group: Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of Molecules-From Basics to Practical Applications [0.03%]
欧洲毒理病理学会-质谱成像特别兴趣小组：诊断和毒理病理学中的质谱成像技术-从基础到实际应用（无标记分子检测）
Enrico Vezzali,Michael Becker,Fernando Romero-Palomo et al.
Enrico Vezzali et al.
Mass Spectrometry Imaging (MSI) is a powerful tool to understand molecular pathophysiology and therapeutic and toxicity mechanisms, as well as for patient stratification and precision medicine. MSI, a label-free technique offering detailed ...
Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation [0.03%]
通过分子定位研究表征毛里求斯食蟹猴脊髓中反义寡核苷酸诱导的组织病理学发现
Valérie Dubost,Kuno Wuersch,Kelley Penraat et al.
Valérie Dubost et al.
The safety of a 2'-O-methoxyethyl antisense oligonucleotide (ASO) was investigated in Mauritius cynomolgus monkeys in a 41-week Good Laboratory Practice (GLP) toxicity study after multiple intrathecal (IT) administrations. Histopathological...
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies [0.03%]
科学与监管政策委员会 建议：减少非临床毒性研究中对照实验恒河猴安乐死的提案及推荐意见
Magali Guffroy,Tara Arndt,Erio Barale-Thomas et al.
Magali Guffroy et al.
Nonhuman primates (NHPs) have been and remain a highly valuable animal model with an essential role in translational research and pharmaceutical drug development. Based on current regulatory guidelines, the nonclinical safety of novel thera...
Applications of Molecular Pathology: An Evolving Approach to Toxicologic Pathology [0.03%]
分子病理学在毒理病理学中的应用及研究思路的转变
Ingrid Cornax,Dinesh S Bangari,Vinicius Carreira et al.
Ingrid Cornax et al.
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products [0.03%]
基于细胞的蛋白质微阵列技术在生物制品非临床安全性评价中的应用研究
Axel Vicart,Cam Holland,Kathryn Fraser et al.
Axel Vicart et al.
Off-target evaluation is essential in preclinical safety assessments of novel biotherapeutics, supporting lead molecule selection, endpoint selection in toxicology studies, and regulatory requirements for first-in-human trials. Off-target i...
Historical Control Data of Spontaneous Lesions of Laboratory New Zealand White and Dutch Belted Rabbits (Oryctolagus Cuniculus) Used in Toxicity Studies [0.03%]
用于毒理学研究的实验新西兰白兔和荷兰围腰兔(Oryctolagus cuniculus)自发性病变的历史对照数据
Davide Corbetta,Kaori Isobe,Romaisa Masood et al.
Davide Corbetta et al.
A retrospective study was performed to determine the incidences of spontaneous findings in control laboratory New Zealand White (NZW) and Dutch Belted (DB) rabbits. Terminal body and organ weights data were also collected. A total of 2170 N...
Multiplexed siRNA Immunoassay Unveils Spatial and Quantitative Dimensions of siRNA Function, Abundance, and Localization In Vitro and In Vivo [0.03%]
多重siRNA免疫测定法揭示了siRNA的体内和体外功能、丰度和定位的时空和定量维度
Michael Ly,Sandra Diaz-Garcia,Nathaniel Roscoe et al.
Michael Ly et al.
Small interfering RNAs (siRNAs) have been successfully used as therapeutics to silence disease-causing genes when conjugated to ligands or formulated in lipid nanoparticles to target relevant cell types for efficacy while sparing other cell...
Integration of Chromogenic RNAscope In Situ Hybridization for Target Validation in Drug Discovery [0.03%]
染色RNA检测原位杂交靶点验证在药物发现中的应用集成
Rosanna Win,Wesley Minto,In Kyoung Mah et al.
Rosanna Win et al.
Characterizing the expression of novel targets in normal and diseased tissues is a fundamental component of a target validation data package. Often these targets are presented to the pathology team for assessment with bulk or single-cell RN...
Brad Bolon,Amber Moser,Elizabeth Chlipala
Brad Bolon
Hematoxylin and eosin (H&E) staining is a suitable approach for detecting substantial structural changes in neural tissues but is less sensitive for identifying subtle alterations to subcellular structures and various chemical constituents,...
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review-Are We There Yet? [0.03%]
毒理病理学论坛：数字初次阅片和同行评审的意见-我们已经准备好了吗？
Kenneth A Schafer,Deepa B Rao
Kenneth A Schafer
Recent trends in toxicological pathology include implementation of digital platforms that have gained rapid momentum in the field. Are we ready to fully implement this new modality? This opinion piece provides some practical perspectives on...