Scientific and Regulatory Policy Committee Points to Consider* for Determining and Reporting Cause of Death/Moribundity in Non-Rodent Species in Toxicity Studies [0.03%]
毒性研究中确定和报告非啮齿类动物死亡/濒死原因的科学与法规政策委员会需考虑的因素*
Karyn Colman,Kathleen A Funk,Michael Boyle et al.
Karyn Colman et al.
The Cause of Death in Non-Rodents (CODN) Working Group is an initiative under the Scientific and Regulatory Policy Committee (SRPC) of the Society of Toxicologic Pathology (STP), focused on understanding existing practices and expectations ...
Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies [0.03%]
2023年法国毒理病理学会年度科学会议关于基于mRNA技术的临床前开发和治疗应用的论文集
Pierluigi Fant,Sébastien Laurent,Paul Desert et al.
Pierluigi Fant et al.
The 2023 annual scientific meeting of the French Society of Toxicologic Pathology (Société Française de Pathologie Toxicologique, SFPT), entitled "mRNA-based technologies: preclinical development and therapeutic applications," was held i...
Corrigendum to Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location [0.03%]
毒理病理学论坛的勘误：对在远程位置进行良好实验室规范组织病理学评估的非临床毒性研究的意见
Published Erratum
Toxicologic pathology. 2025 Mar 18:1926233251322124. DOI:10.1177/01926233251322124 2025
Pierre Maliver,Julie Boisclair,Ingrid Pardo et al.
Pierre Maliver et al.
The last session of the 2024 European Society of Toxicologic Pathology Congress was dedicated to recent neuro concepts, encompassing various topics including artificial intelligence (AI) applied to toxicologic pathology, new technologies fo...
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey (Macaca fascicularis) [0.03%]
病例报告：幼年猕猴(Macaca fascicularis)大脑皮层的胶质神经元畸形病病变
Elaine Debien,Felix Goulet,Lee Silverman et al.
Elaine Debien et al.
Two dark and raised foci were observed on the left hemisphere of the brain of a 3-year-old cynomolgus monkey during the routine necropsy procedures of a preclinical toxicity study. Microscopic examination revealed a lesion in the cerebral c...
Comparisons of the Sensitivity of Histopathological and Immunohistochemical Analyses With Blood Hormone Levels for Early Detection of Antithyroid Effects in Rats Treated With Promoters of Thyroid Hormone Metabolism [0.03%]
组化和免疫组化分析与血液激素水平对甲状腺素代谢促进剂导致的大鼠抗甲状腺效应早期检测的敏感性比较研究
Hirotoshi Akane,Takeshi Toyoda,Kohei Matsushita et al.
Hirotoshi Akane et al.
Although blood triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels are useful for detecting antithyroid compounds in rodent toxicity studies, there are challenges with high variability due to sampling conditi...
Molecular Pathology Methods to Characterize Biodistribution and Pharmacodynamics of the Oncolytic Virus VSV-GP in a Nonclinical Tumor Model [0.03%]
用于表征非临床肿瘤模型中溶瘤病毒VSV-GP的生物分布和药效学的分子病理方法
Andrea Matter,Karol Budzik,Saurin Mehta et al.
Andrea Matter et al.
Replication-competent oncolytic virus (OV) therapies are a promising new modality for cancer treatment. However, they pose unique challenges for preclinical assessment, due in part to their tumor specificity and ability to self-replicate in...
Mitigating Nephrotoxicity Risks and Ranking Drug Candidates Using MALDI Mass Spectrometry Imaging: A Case Study [0.03%]
利用MALDI质谱成像减轻肾毒性风险并评估候选药物：一个案例研究
Bingming Chen,Lisa LaFranco-Scheuch,Shuzhi Dong et al.
Bingming Chen et al.
Drug-induced nephrotoxicity is a major challenge in drug discovery and development, accounting for nearly a quarter of severe adverse effects in current pharmacotherapy. Antimicrobial use may be associated with this problem, with one-third ...
2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: "Medical Device Safety Assessment: Pathology and Toxicology Perspective" [0.03%]
2023国际毒理病理学会(IATP)卫星会议：“医疗器械安全性评价：病理学和毒理学视角”
Flora Wegener,Antoine Alves,Uta Bussmeyer et al.
Flora Wegener et al.
Medical devices represent a complex category of medicinal products with varying definitions depending on the regional jurisdiction of regulatory agencies. A common aspect of these definitions is that a medical device is intended to be used ...
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development [0.03%]
ESTP病理学2.0工作组的几点考虑：支持药物发现和开发的空间组学技术概览
Kerstin Hahn,Bettina Amberg,Josep M Monné Rodriguez et al.
Kerstin Hahn et al.
Recent advances in bioanalytical and imaging technologies have revolutionized our ability to assess complex biological and pathological changes within tissue samples. Spatial omics, a rapidly evolving technology, enables the simultaneous de...