STP Town Hall Discussion on the Use of Virtual Control Groups in Nonclinical Toxicity Studies [0.03%]
STP大会关于在非临床毒性研究中使用虚拟对照组的讨论会
Kirstin Barnhart,Brad Bolon,Laura Boone et al.
Kirstin Barnhart et al.
The 2025 Town Hall meeting of the Society of Toxicologic Pathology (STP) discussed virtual control groups (VCG) in nonclinical toxicity testing, which are being pursued by multiple organizations to reduce animal use in product development. ...
Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System: Revised INHAND Terms for Ovarian Sex Cord/Stromal Lesions [0.03%]
大鼠和小鼠雌性生殖系统非增生性和增生性病变：卵巢性索/间质病变的INHAND修订术语
Ute Bach Chair,Heike A Marxfeld,Justin D Vidal et al.
Ute Bach Chair et al.
The nomenclature for the female reproductive system was originally published in 2014. After 10 years of practical use, the scientific community requested from the organ working group (OWG) a review of the terminology and criteria for diagno...
Ricardo de Miguel,Paula Ortega,Klaus Weber et al.
Ricardo de Miguel et al.
The high metabolic demand and complex blood supply of the central nervous system (CNS) render it susceptible to both global and focal ischemic insults, which represent a leading cause of morbidity and mortality in humans. The effects of isc...
An Introduction to the Society of Toxicologic Pathology's 44th Annual Symposium on Toxicologic Neuropathology: Basics and Beyond [0.03%]
毒理病理学会第44届年度神经毒理学病理学术会议介绍：基础与前沿
Ingrid D Pardo,Caroline J Zeiss,LuAnn McKinney
Ingrid D Pardo
Multimodality Investigative Pathology: Leveraging the Full Potential of Spatial Pathobiology in Pharmaceutical Therapeutic Discovery and Development [0.03%]
多模态病理学：在药物治疗发现和开发中充分挖掘空间病理生物学的潜力
Anoop Kavirayani,Saravanan Kaliyaperumal,Chandra Saravanan et al.
Anoop Kavirayani et al.
Contemporary pathology is increasingly multimodal and requires the application and integration of newer molecular methods to complement classical morphologic evaluation. In diagnostic medical pathology, especially cancer pathology, integrat...
Jeffrey T Joseph
Jeffrey T Joseph
The cerebellum has intricate connections either directly or indirectly with most levels of the brain. While many of these are functionally relevant, prominent neuropathologic changes that reflect the underlying anatomy arise from injury to ...
Debra A Tokarz
Debra A Tokarz
Neuronal cell death is an irreversible, end-stage cellular response. Programmed cell death of neurons is integral to nervous system development. However, terminally differentiated neurons represent an essentially non-regenerative cell popul...
Microscopic Findings in Seminal Vesicles of Control Rats Mated to Females From Fertility and Early Embryonic Development Studies [0.03%]
对照组大鼠与生殖和早期胚胎发育研究中使用过的雌鼠交配后精囊的显微镜检查结果
Emmanuelle Balme,Bernd Baier,Katja Hempel et al.
Emmanuelle Balme et al.
Male reproductive organs are rarely examined microscopically in developmental and reproductive toxicity (DART) studies. Therefore, few background histopathological data exist for breeding animals. Yet, toxicologic pathologists must be able ...
Toxicologic Pathology Forum*: Opinion on the Future of Histopathology Using Whole Slide Images in Toxicologic Pathology of Preclinical Studies and Its Successful Implementation in Compliance With Good Laboratory Practice-Yes, We Are There! [0.03%]
毒理病理学论坛：关于在非临床试验毒理病理学中使用全片数字切片的未来及符合良好实验室规范的成功实施的意见——是的，我们已经做到了！
Bob Thoolen,Alys Bradley,Nikolas Stathonikos et al.
Bob Thoolen et al.
Digital pathology (DP) for the purpose of primary reads has emerged as a transformative tool in the practice of histopathology and has already proved to be suitable, bringing numerous advantages over traditional light microscopy (LM). This ...
Reliable Identification of Alpha2u-Globulin and Lysozyme Accumulation in Rat Kidney by Label-Free MALDI Mass Spectrometry Imaging [0.03%]
基于MALDI质谱成像的无标记α2u-球蛋白及溶菌酶肾蓄积可靠识别方法
Stefania-Alexandra Iakab,Heike Antje Marxfeld,Florian M Richter et al.
Stefania-Alexandra Iakab et al.
The molecular identification of alpha2 urinary protein in male rat kidneys is crucial in distinguishing human relevant from rat-specific cases of nephropathy caused by protein accumulation. As protein accumulation in the kidney presents uni...