Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery [0.03%]
神经退行性疾病：发病机理和转化药物研发的非临床模型
Laura Fusaro,Dinesh S Bangari,R Jeroen Pasterkamp et al.
Laura Fusaro et al.
The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo models to investigate neurodegenerative diseases. Four presentations highlighted v...
A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation [0.03%]
神经临床与病理评估的相互作用：形式与功能的盛宴
Brad Bolon,Joe N Kornegay
Brad Bolon
The central (CNS) and peripheral (PNS) nervous systems of vertebrates represent divisions of a continuous, body-wide communication grid based on conserved principles of structural organization. Discrete neuroanatomic regions within this gri...
Bilateral Basal Nuclei Vacuolar Lesions: A Novel and Emerging Potential Background Finding in Beagle Dogs [0.03%]
双侧基底神经节空泡病变： beagle犬中的一个新颖且潜在的背景发现
Stefanie Arms,Stephen D Cahalan,Felix Goulet et al.
Stefanie Arms et al.
In this case presentation, the speaker and co-authors represented a group of scientists engaged in a cross-institutional precompetitive working group focused on elucidating a novel background change in the basal nuclei of Beagle dogs. The g...
Inaugural Special Issue Celebrating the 21st Annual Congress of the European Society of Toxicologic Pathology [0.03%]
庆祝欧洲毒理病理学年会第21届大会的创刊特辑
Dinesh S Bangari,Saravanan Kaliyaperumal
Dinesh S Bangari
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies [0.03%]
神经生物标志物的基本方面及其在非临床研究中的相关性
Andrea Greiter-Wilke,Nicolau Beckmann,Warren E Glaab et al.
Andrea Greiter-Wilke et al.
The second session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress highlighted the significance of neural biomarkers and functional endpoints in nonclinical studies for detecting acute or delayed peripheral (PNS) and c...
Toxicologic Pathology Forum: Opinion on Addressing Gaps in INHAND Terminology for Medical Devices-A Proposal to Add New Diagnostic Nomenclature [0.03%]
毒理病理学论坛：关于解决INHAND术语中有关医疗器械的空白的意见以及增加新的诊断术语的建议
JoAnn C L Schuh,Lyn M Wancket,Brad Bolon et al.
JoAnn C L Schuh et al.
Historically, safety and efficacy assessment of medical devices began and has continued as standards under the International Organization for Standardization (ISO) rather than under regulatory agency guidelines applied to developing other b...
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024 [0.03%]
从病理学角度探讨免疫毒理学：在美国马里兰州巴尔的摩举行的年度STP会议（时间为2024年6月16日至19日）上呈现的继续教育课程
Tracey L Papenfuss,Ashwini Phadnis Moghe,Lauren E Himmel et al.
Tracey L Papenfuss et al.
This article is a summary of a half-day continuing education course jointly sponsored by the Society for Toxicologic Pathology (STP) and the Health and Environmental Sciences Institute (HESI) at the annual meeting of the STP in Baltimore, M...
Toxicologic Pathology Forum*: Opinion on New Technologies and Trends Disrupting Drug Discovery and Development: How Can the Next Generation of Toxicologic Pathologists Be Prepared for Evolving Roles? [0.03%]
毒理病理学论坛*：对颠覆药物研发的新技术和趋势的意见：如何为毒理病理学家角色的转变做好准备？
Rebecca Kohnken,Lauren Himmel,Magali Guffroy et al.
Rebecca Kohnken et al.
The pace of technological innovation in the pharmaceutical industry, like in many other sectors, is accelerating rapidly. This is not only reshaping how pharmaceutical Research and Development (R&D) is conducted (e.g., introduction of novel...
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology [0.03%]
动物研究中的诠释挑战：案例研究回顾及其对毒性病理学的影响
Ruba Ibrahim,Abraham Nyska,Susan A Elmore et al.
Ruba Ibrahim et al.
Toxicologic pathologists play a crucial role in the evaluation of animal studies for drugs, environmental chemicals, medical devices, and other agents to determine their safety and potential toxic effects. A significant challenge in this do...
Mini Review: Spatial Transcriptomics to Decode the Central Nervous System [0.03%]
迷你综述：空间转录组学在解码中枢神经系统中的应用
Benedek Pesti,Xavi Langa,Nadine Kumpesa et al.
Benedek Pesti et al.
Spatial transcriptomics (ST) is revolutionizing our understanding of the central nervous system (CNS) by providing spatially resolved gene expression data. This mini review explores the impact of ST on CNS research, particularly in neurodeg...