Evaluation of Biomarkers to Detect Early Prothrombotic Imbalance in Rat Models of Hypercoagulability Induced by Thromboplastin Infusion and Hypofibrinolysis Induced by Tranexamic Acid [0.03%]
评估纤溶酶原激活物抑制剂-1和血栓调节蛋白作为检测由组织因子和氨甲环酸诱导的实验动物模型早期促凝状态生物标志物的能力
Marjory B Brooks,Cindy E Fishman,Mohanapriya Kamalakannan et al.
Marjory B Brooks et al.
Thrombotic complications including myocardial infarction, stroke, venous thrombosis and pulmonary thromboembolism are common causes of drug attrition often discovered at late stages of drug development. Current nonclinical safety assessment...
Deep Learning Methodology for Quantification of Normal Pancreas Structures [0.03%]
深度学习方法在正常胰腺结构量化中的应用
Zhiyong Xie,Stephane Thibault,Norimitsu Shirai et al.
Zhiyong Xie et al.
Histopathologic evaluation plays a crucial role in assessing morphological tissue alterations in disease models and toxicology studies. Identifying small quantitative shifts in specific substructures of organs can be challenging due to the ...
Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology-The Current State, Challenges, and Future Directions [0.03%]
数字病理学与人工智能在非临床毒理病理中的应用-现状、挑战及未来方向
Gabriele Pohlmeyer-Esch,Charles Halsey,Julie Boisclair et al.
Gabriele Pohlmeyer-Esch et al.
Advancements in digital pathology and artificial intelligence (AI) have enormous transformative potential for nonclinical toxicologic pathology and are already changing the ways in which pathologists work. However, due to the rapid evolutio...
Neuromethods: Basic Techniques for Evaluating the Nervous System in Nonclinical Studies [0.03%]
神经方法：评估非临床研究中神经系统的基本技术
Deepa B Rao,Xavier Palazzi,Alexandra Duetting et al.
Deepa B Rao et al.
The first session of the 2025 European Society of Toxicologic Pathology (ESTP) Congress reviewed routine and specialized methods for microscopic evaluation of neural tissues during nonclinical studies. Three longer presentations reviewed br...
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies [0.03%]
毒理病理论坛：解剖和临床病理数据的统计显著性结果在非临床安全性研究中的解读意见
Lila Ramaiah,Tara Arndt,Gareth Thomas et al.
Lila Ramaiah et al.
Toxicologic pathologists assess large data sets from nonclinical studies to identify treatment-related effects to assist in predicting human safety hazards. Statistical testing can facilitate data interpretation by highlighting group differ...
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies [0.03%]
毒理病理论坛*：关于在非临床毒性研究中表达临床病理终点改变量的定性严重度描述符的意见
N K Tripathi,L Ramaiah,T Arndt et al.
N K Tripathi et al.
Clinical pathology endpoints are routinely assessed in nonclinical toxicity studies and the magnitude of test article-related changes is frequently expressed using quantitative and/or qualitative severity descriptors. Quantitative descripto...
Developmental Neurotoxicity (DNT) Studies for Chemical Safety Assessments: Basic Concepts, Experimental Strategies, and Future Directions [0.03%]
化学品安全评估中的发育神经毒性(DNT)试验的基本概念、实验策略和未来方向
Wolfgang Kaufmann,Frederic Schorsch,Heike Marxfeld et al.
Wolfgang Kaufmann et al.
The 21st ESTP's (European Society of Toxicology Pathology) Annual Congress (2024) included a 3-hour scientific session on developmental neurotoxicity (DNT) as applied to chemical safety assessments. Key concepts of this session were to prov...
Comparison of an Attention-Based Multiple Instance Learning (MIL) With a Visual Transformer Model: Two Weakly Supervised Deep Learning (DL) Algorithms for the Detection of Histopathologic Lesions in the Rat Liver to Distinguish Normal From Abnormal [0.03%]
基于注意力的多重实例学习与视觉变换器模型的比较：两种弱监督深度学习算法在检测大鼠肝脏组织病理病变以区分正常和异常情况方面的应用研究
Juergen Funk,Gregoire Clement,Matteo Togninalli et al.
Juergen Funk et al.
The histopathologic evaluation of regulatory toxicity studies using artificial intelligence (AI) has the potential to increase study efficiency. For example, AI could initially identify and exclude all organs without histopathologic lesions...
2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives [0.03%]
2024国际毒理病理学会(IATP)卫星会议：神经毒性评估的新方法(NAMs)及监管展望
Helena T Hogberg,Ellen Fritsche,Sibylle Gröters et al.
Helena T Hogberg et al.
The International Academy of Toxicologic Pathology (IATP) Satellite Symposium on "New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives," organized in Spain, addressed the growing need for improved asses...
Uveodermatologic Syndrome in a Laboratory Beagle Dog: Histological and Immunohistochemical Features [0.03%]
实验室比格犬的虹膜炎皮肤病综合征：组织学和免疫组化特征
Giulia Tosi,Elisavet Karamanavi,Zuhal Dincer et al.
Giulia Tosi et al.
This brief communication details the clinical, macroscopic, histological, and immunohistochemical features of a spontaneous case of uveodermatologic syndrome (UDS) in a laboratory beagle dog. A bilateral and symmetrical panuveitis, rich in ...