Multimodality Investigative Pathology: Leveraging the Full Potential of Spatial Pathobiology in Pharmaceutical Therapeutic Discovery and Development [0.03%]
多模态病理学：在药物治疗发现和开发中充分挖掘空间病理生物学的潜力
Anoop Kavirayani,Saravanan Kaliyaperumal,Chandra Saravanan et al.
Anoop Kavirayani et al.
Contemporary pathology is increasingly multimodal and requires the application and integration of newer molecular methods to complement classical morphologic evaluation. In diagnostic medical pathology, especially cancer pathology, integrat...
Jeffrey T Joseph
Jeffrey T Joseph
The cerebellum has intricate connections either directly or indirectly with most levels of the brain. While many of these are functionally relevant, prominent neuropathologic changes that reflect the underlying anatomy arise from injury to ...
Debra A Tokarz
Debra A Tokarz
Neuronal cell death is an irreversible, end-stage cellular response. Programmed cell death of neurons is integral to nervous system development. However, terminally differentiated neurons represent an essentially non-regenerative cell popul...
Microscopic Findings in Seminal Vesicles of Control Rats Mated to Females From Fertility and Early Embryonic Development Studies [0.03%]
对照组大鼠与生殖和早期胚胎发育研究中使用过的雌鼠交配后精囊的显微镜检查结果
Emmanuelle Balme,Bernd Baier,Katja Hempel et al.
Emmanuelle Balme et al.
Male reproductive organs are rarely examined microscopically in developmental and reproductive toxicity (DART) studies. Therefore, few background histopathological data exist for breeding animals. Yet, toxicologic pathologists must be able ...
Toxicologic Pathology Forum*: Opinion on the Future of Histopathology Using Whole Slide Images in Toxicologic Pathology of Preclinical Studies and Its Successful Implementation in Compliance With Good Laboratory Practice-Yes, We Are There! [0.03%]
毒理病理学论坛：关于在非临床试验毒理病理学中使用全片数字切片的未来及符合良好实验室规范的成功实施的意见——是的，我们已经做到了！
Bob Thoolen,Alys Bradley,Nikolas Stathonikos et al.
Bob Thoolen et al.
Digital pathology (DP) for the purpose of primary reads has emerged as a transformative tool in the practice of histopathology and has already proved to be suitable, bringing numerous advantages over traditional light microscopy (LM). This ...
Reliable Identification of Alpha2u-Globulin and Lysozyme Accumulation in Rat Kidney by Label-Free MALDI Mass Spectrometry Imaging [0.03%]
基于MALDI质谱成像的无标记α2u-球蛋白及溶菌酶肾蓄积可靠识别方法
Stefania-Alexandra Iakab,Heike Antje Marxfeld,Florian M Richter et al.
Stefania-Alexandra Iakab et al.
The molecular identification of alpha2 urinary protein in male rat kidneys is crucial in distinguishing human relevant from rat-specific cases of nephropathy caused by protein accumulation. As protein accumulation in the kidney presents uni...
Calculating Veterinary Clinical Pathology Reference Intervals for Research at the Integrated Research Facility, NIAID: A Practical Application of Data Partitioning and Statistical Methodology [0.03%]
美国NIAID综合研究设施的兽医临床病理参考区间计算研究——数据分区和统计方法的实际应用
Daniel B Woodburn,Jeremy J Bearss,Camille M Lake et al.
Daniel B Woodburn et al.
The veterinary research community requires statistically robust reference intervals in which to contextualize the results of laboratory tests obtained in research studies. While published reference intervals are available for veterinary cli...
Histopathologic Findings in the Heart Associated With Telemetry Instrumentation in Beagle Dogs [0.03%]
与监测仪器相关的Beagle犬心脏组织病理学发现
Rebecca Kohnken,Amanda Wilsey,Brandan Bird et al.
Rebecca Kohnken et al.
Conscious telemetry-instrumented dogs are used during cardiovascular safety assessment in early drug development for the collection of cardiovascular function parameters such as electrocardiography (ECG), heart rate, mean arterial pressure,...
Intrahepatic Cholangiocarcinoma With Pulmonary Metastasis in a Rhesus Macaque (Macaca mulatta) [0.03%]
恒河猴（猕猴）肝内胆管癌伴肺转移
Andressa Varella Gonsioroski,Mayra Tsoi,Meredith Leigh Cronin et al.
Andressa Varella Gonsioroski et al.
A 28-year-old, female Rhesus macaque (Macaca mulatta) was lethargic and inappetent despite supportive treatment. Euthanasia was elected. Necropsy revealed numerous nodules in the liver and lung. Microscopically, the liver and lung were mult...
Rare Occurrence of an Acute Myeloid Leukemia in a Cynomolgus Macaque (Macaca fascicularis) [0.03%]
一只 cynomolgus macaque（猕猴）患急性髓系白血病的罕见病例报告
Heather Priest,Julie Schwartz,Angela Wilcox et al.
Heather Priest et al.
This report presents the findings of a spontaneous case of acute myeloid leukemia (AML) in a 6-year-old male cynomolgus macaque enrolled in a 9-month repeat dose-toxicity and toxicokinetic study. Abnormal hematology findings occurred approx...