Distinguishing cystic degeneration from other aging lesions in the adrenal cortex of Sprague-Dawley rats [0.03%]
Sprague-Dawley大鼠肾上腺皮质囊性变性与其它老化病变的区别诊断
Victoria A Laast,Thomas Larsen,Neil Allison et al.
Victoria A Laast et al.
Cystic degeneration of the adrenal cortex is a common age-related finding in the Sprague-Dawley (SD) rat strain occurring more frequently in females. Compression of the adjacent cortex, a common hallmark of benign adrenal cortical tumors, o...
Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways [0.03%]
氯乙烯氯暴露的F344/N大鼠间皮瘤基因表达谱揭示了免疫功能障碍、组织损伤及炎症通路异常
Pamela E Blackshear,Arun R Pandiri,Hiroaki Nagai et al.
Pamela E Blackshear et al.
A majority (∼80%) of human malignant mesotheliomas are asbestos-related. However, non-asbestos risk factors (radiation, chemicals, and genetic factors) account for up to 30% of cases. A recent 2-year National Toxicology Program carcinogeni...
Rossella Defazio,Ana Criado,Valentina Zantedeschi et al.
Rossella Defazio et al.
Brain trimming through defined neuroanatomical landmarks is recommended to obtain consistent sections in rat toxicity studies. In this article, we describe a matrix-guided trimming protocol that uses channels to reproduce coronal levels of ...
Gitte Jeppesen,Mikala Skydsgaard
Gitte Jeppesen
The Göttingen minipig is gaining increasing popularity as a nonrodent species in nonclinical testing. The Göttingen minipig is easy to handle; has many anatomical and physiological similarities to man; and causes fewer ethical concerns th...
Mark Timothy Butt,Katharine Mason Whitney,Wendell Davis et al.
Mark Timothy Butt et al.
Brain sections from control cynomolgus monkeys (Macaca fascicularis) used in toxicology studies were evaluated retrospectively in order to better understand spontaneous background changes in this species. Hematoxylin and eosin-stained slide...
A 28-day gavage toxicity study in Fischer 344 rats with 3-methylfuran [0.03%]
3-甲基呋喃对Fischer 344大鼠28天经口毒性研究
Santokh Gill,Meghan Kavanagh,Wendy Cherry et al.
Santokh Gill et al.
3-Methylfuran is produced in foods during food processing and preservation techniques that involve heat treatment such as cooking, jarring, canning, and pasteurization. Currently, there are no studies available on the toxicity of 3-methylfu...
Inhibitory potential of postnatal treatment with cyclopamine, a hedgehog signaling inhibitor, on medulloblastoma development in Ptch1 heterozygous mice [0.03%]
Ptch1杂合小鼠产后用刺猬信号抑制剂辛波氨治疗的抑瘤潜力研究
Saori Matsuo,Miwa Takahashi,Kaoru Inoue et al.
Saori Matsuo et al.
Medulloblastomas (MBs) are thought to be derived from granular cell precursors in the external granular layer (EGL) of the developing cerebellum. Heterozygous patched1 (Ptch1) knockout mice develop MBs that resemble those in humans when the...
Regulatory Forum opinion piece: New testing paradigms for reproductive and developmental toxicity--the NTP modified one generation study and OECD 443 [0.03%]
监管论坛评论文章：用于生殖和发育毒理学的新检测体系——NTP改良一代研究和经合组织443号准则
Paul M D Foster
Paul M D Foster
The National Toxicology Program (NTP) has developed a new flexible study design, termed the modified one generation (MOG) reproduction study. The MOG study will encompass measurements of developmental and reproductive toxicity parameters as...
Interspecies differences in reaction to a biodegradable subcutaneous tissue filler: severe inflammatory granulomatous reaction in the Sinclair minipig [0.03%]
生物可降解组织填充剂在不同物种间的反应差异：辛克莱小型猪的严重炎性肉芽肿反应
Yuval Ramot,Dan Touitou,Galit Levin et al.
Yuval Ramot et al.
Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic indications. While generally considered safe, the number of reported complications with tissue fillers is growing. Nevertheless...
Comparative Study
Toxicologic pathology. 2015 Feb;43(2):267-71. DOI:10.1177/0192623314534995 2015
FutureTox II: Contemporary Concepts in Toxicology: "Pathways to prediction: in vitro and in silico models for predictive toxicology" [0.03%]
预测毒理学的体外和计算模型：通向预测之路
Susan A Elmore,Anne M Ryan,Charles E Wood et al.
Susan A Elmore et al.