Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis) [0.03%]
一种单克隆抗体诱导的猕猴（ cynomolgus monkey）免疫复合物疾病的特征、生物标志物及其可逆性研究
Jonathan R Heyen,Jennifer Rojko,Mark Evans et al.
Jonathan R Heyen et al.
Two 6-month repeat-dose toxicity studies in cynomolgus monkeys illustrated immune complex-mediated adverse findings in individual monkeys and identified parameters that potentially signal the onset of immune complex-mediated reactions follo...
Daniel Morton,Christopher D Houle,Lindsay Tomlinson
Daniel Morton
Comparative nonclinical assessments of the proposed biosimilar PF-05280586 and rituximab (MabThera®) [0.03%]
PF-05280586(帕利珠单抗)与利妥昔单抗(MabThera)非临床对比评估研究
Anne M Ryan,Sharon A Sokolowski,Chee-Keng Ng et al.
Anne M Ryan et al.
Comparative nonclinical studies were conducted with the proposed biosimilar PF-05280586 and rituximab-EU (MabThera®). In side-by-side analyses, peptide maps and complement-dependent cytotoxicity assay results were similar. Sexually-mature ...
Comparative Study
Toxicologic pathology. 2014 Oct;42(7):1069-81. DOI:10.1177/0192623313520351 2014
Brunner's gland lesions in rats induced by a vascular endothelial growth factor receptor inhibitor [0.03%]
血管内皮生长因子受体抑制剂诱导的大鼠Brunner腺病变
Akira Inomata,Kyoko Nakano-Ito,Yasuhiro Fujikawa et al.
Akira Inomata et al.
Vascular endothelial growth factor (VEGF) receptor tyrosine kinase (RTK) inhibitors are reported to cause reversible mucosal hyperplasia (adenosis) in the duodenum of rats; however, the pathogenesis is not fully elucidated. Using lenvatinib...
Evaluation of von Willebrand factor and von Willebrand factor propeptide in models of vascular endothelial cell activation, perturbation, and/or injury [0.03%]
血管内皮细胞活化、紊乱和/或损伤模型中von Willebrand因子和前体肽的评估
David A Brott,Anne Katein,Heath Thomas et al.
David A Brott et al.
Pharmacologically, vasoactive agents targeting endothelial and/or smooth muscle cells (SMC) are known to cause acute drug-induced vascular injury (DIVI) and the resulting pathology is due to endothelial cell (EC) perturbation, activation, a...
Incidence of spontaneous central nervous system tumors in CD-1 mice and Sprague-Dawley, Han-Wistar, and Wistar rats used in carcinogenicity studies [0.03%]
Sprague-Dawley、汉Wistar和Wistar大鼠及CD-1小鼠发生中枢神经系统肿瘤自发发病率的比较研究报告
Lise Bertrand,Sydney Mukaratirwa,Alys Bradley
Lise Bertrand
The incidence and range of spontaneous central nervous system tumors were determined in control Charles River rodents (Sprague-Dawley, Han-Wistar, Wistar rats, and CD-1 mice) from regulatory carcinogenicity studies carried out over the peri...
The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource [0.03%]
国家毒理学项目网络版非肿瘤损伤图谱：全球毒理学和病理学资源
Mark F Cesta,David E Malarkey,Ronald A Herbert et al.
Mark F Cesta et al.
Toxicologists and pathologists worldwide will benefit from a new, website-based, and completely searchable Nonneoplastic Lesion Atlas just released by the U.S. National Toxicology Program (NTP). The atlas is a much-needed resource with thou...
Extending the statistical analysis and graphical presentation of toxicity test results using standardized effect sizes [0.03%]
基于标准化效应量的毒理学试验统计分析和图形表示的发展
Michael F W Festing
Michael F W Festing
The results of repeat-dose toxicity tests are usually presented as tables of means and standard deviations (SDs), with an indication of statistical significance for each biomarker. Interpretation is based mainly on the pattern of statistica...
Injection-site malignant fibrous histiocytomas in a pegvisomant carcinogenicity study in SD rats [0.03%]
PEGVISOMANT导致大鼠致瘤性试验中的注射部位恶性组织细胞瘤
Phillip M Bartholomew,John M Kreeger,Daniel Morton
Phillip M Bartholomew
In a 2-year rat carcinogenicity study, pegvisomant injected subcutaneously on a daily basis at doses of 0, 2, 8, or 20 mg/kg/day produced malignant fibrous histiocytomas (MFHs) at the injection sites of 3 male rats (5%) given 8 mg/kg/day an...
Gary Cockerell
Gary Cockerell
A new service to facilitate career advancement opportunities has been implemented by the American College of Veterinary Pathologists (ACVP)/Society of Toxicologic Pathology (STP) Coalition for Veterinary Pathology Fellows. This service will...