Nanna Grand,Gitte Jeppesen,Abraham Nyska
Nanna Grand
Minipigs are valued alternatives to dogs and non-human primates in non-clinical safety and toxicity studies, and Göttingen minipigs are bred specifically for experimental purposes. They are bred under barrier conditions and monitored regul...
Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries [0.03%]
外源性生长激素加重放射后的动脉粥样硬化病情
Krystal J Vail,J Daniel Bourland,Gregory O Dugan et al.
Krystal J Vail et al.
Cardiac exposure to ionizing radiation can damage both the microvasculature and coronary arteries, as well as increase the long-term risk of heart disease, myocardial fibrosis, and conduction abnormalities. Therapeutic agents capable of pro...
Toxicologic Pathology Forum: mRNA Vaccine Safety-Separating Fact From Fiction [0.03%]
毒理病理学论坛：mRNA疫苗的安全性——区分事实与虚构
Rani S Sellers,Philip R Dormitzer
Rani S Sellers
SARS-CoV-2 spread rapidly across the globe, contributing to the death of millions of individuals from 2019 to 2023, and has continued to be a major cause of morbidity and mortality after the pandemic. At the start of the pandemic, no vaccin...
Biocompatible Solutions: Evaluating the Safety of Repeated Intra-Articular Injections of pMPCylated Liposomes for Knee Osteoarthritis Therapy in Rat Models [0.03%]
生物相容性溶液：评估pMPC基脂质体反复膝关节腔注射治疗膝骨关节炎的安全性（大鼠模型）
Yuval Ramot,Noam Kronfeld,Michal Steiner et al.
Yuval Ramot et al.
Knee osteoarthritis (OA) poses a significant health care burden globally, necessitating innovative therapeutic approaches. CCoat, a novel poly(2-[methacryloyloxy]ethyl phosphorylcholine) (pMPC)ylated liposome device, protects the cartilage ...
John M Cullen,David Malarkey,John R Foster
John M Cullen
Abnormal findings in the biliary tree are frequently encountered in response to acute and chronic exposures to various compounds. The more common findings are described here in an overview of previous publications such as the INHAND Prolife...
Characterization of an Uncommon Finding in the Basal Nuclei in Beagle Dogs: A Novel Potential Background Lesion in the Canine Brain [0.03%]
贝杰犬脑基底神经节中不常见发现的特征描述：犬脑中的潜在背景病变的新表型
Stefanie Arms,Katja Hempel,Sophie Rau et al.
Stefanie Arms et al.
Degenerative lesions specific to the basal nuclei have not been described as a background finding in Beagle dogs. This report comprises a documentation of seven cases. In the context of a nonclinical safety studies, the authors suggest docu...
Renee Hukkanen
Renee Hukkanen
Ginsenoside Rh2 Regulates the Calcium/ROS/CK1α/MLKL Pathway to Promote Premature Eryptosis and Hemolysis in Red Blood Cells [0.03%]
人参皂苷Rh2通过调节钙/活性氧/酪蛋白激酶1α/mlkl途径促进红细胞早期血影形成和溶血
Sumiah A Alghareeb,Jawaher Alsughayyir,Mohammad A Alfhili
Sumiah A Alghareeb
Ginsenoside Rh2 (GRh2) exhibits significant potential as an anticancer agent; however, progress in developing chemotherapeutic drugs is impeded by their toxicity toward off-target tissues. Specifically, anemia caused by chemotherapy is a de...
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30 [0.03%]
小鼠呼吸系统发育图谱：从妊娠第9.0天到出生后第30天
Vanessa R Parslow,Susan A Elmore,Robert Z Cochran et al.
Vanessa R Parslow et al.
Respiratory diseases are one of the leading causes of death and disability around the world. Mice are commonly used as models of human respiratory disease. Phenotypic analysis of mice with spontaneous, congenital, inherited, or treatment-re...
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats [0.03%]
与给大鼠施用抗人IL-21受体抗体（ATR-107）相关的免疫介导的肝脏效应学研究
Wenyue Hu,Bernard S Buetow,Karuna Sachdeva et al.
Wenyue Hu et al.
The toxicity of ATR-107, a human anti-interleukin-21 receptor (IL-21R) monoclonal antibody (mAb), was evaluated in CD-1 mice and cynomolgus monkeys after single-dose intravenous (IV) administration, and in Sprague-Dawley (SD) rats and cynom...