Scientific and Regulatory Policy Committee Points to Consider*: Sample Selection, Assay Design, Data Generation and Interpretation, and Reporting Practices for Chromogenic Immunohistochemical (IHC) Assays in Nonclinical Drug Development [0.03%]
科学与监管政策委员会 考虑事项：非临床药物开发中色谱免疫组化(IHC)检测的样本选择、试验设计、数据生成及解释和报告规范
Famke Aeffner,Brad Bolon,Molly H Boyle et al.
Famke Aeffner et al.
Chromogenic immunohistochemistry (IHC) is an important molecular localization assay in biomedical research and nonclinical drug development, enabling the visualization of specific epitopes within tissues. The methodology is widely used in d...
Intraperitoneal Injection of Sesame Oil as Vehicle Induces Decidual Reaction in Female Rats: A Review of In-House Data [0.03%]
芝麻油腹腔注射诱导大鼠子宫内膜反应现象的文献复习
Anikethana Ramesh,Rajesh Karunanithi,Manohar M Deshmukh et al.
Anikethana Ramesh et al.
This review investigates the incidences of decidual reactions and associated microscopic changes in Sprague-Dawley rats comparing dual-route (intravenous-IV + intraperitoneal-IP) to IV-only preclinical studies of nonimplant medical devices ...
A Streptozotocin-Induced Mouse Model of Renal Tumors: Histopathological and Immunohistochemical Comparisons With Human Chromophobe Renal Cell Carcinoma [0.03%]
链佐星诱导的肾肿瘤小鼠模型：与人类嫌色肾细胞癌的组织病理学和免疫组化比较
Yutaro Fukuma,Hideki Mori,Takuji Tanaka et al.
Yutaro Fukuma et al.
Streptozotocin (STZ) is known to induce renal tumors in rodents, but their similarity to human tumors remains poorly defined. We characterized and comparatively validated a mouse model of STZ-induced renal tumorigenesis by administering a s...
Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI [0.03%]
2024年经典毒理病理学案例XXXI研讨会论文集
Charlotte Lempp,Emmanuelle Balme,Robert Lee Johnson et al.
Charlotte Lempp et al.
The 31st edition of the slide seminar "Classic Examples in Toxicologic Pathology" was held at the Department of Pathology at the University of Veterinary Medicine in Hannover, Germany, in March 2024. The meeting series is jointly organized ...
Proceedings of the 2025 Division of Translational Toxicology Satellite Symposium [0.03%]
2025年转化毒理学分会卫星 symposium论文集
Michelle C Cora,Torrie A Crabbs,Frank J Simutis et al.
Michelle C Cora et al.
The 2025 annual Division of Translational Toxicology (DTT) Satellite Symposium, entitled ''Pathology Potpourri'' was held in Chicago, IL, at the Society of Toxicologic Pathology's (STP) 44th annual meeting. This year marked the 25th anniver...
Toxicologic Pathology Forum*: Summary of the 2024 Society of Toxicologic Pathology Town Hall and 2025 STP Member Survey on Determining and Communicating Adversity [0.03%]
毒理病理学论坛*: 2024年毒理病理学会圆桌会议和2025年STP成员调查摘要——确定和沟通不良反应
Kathleen A Funk,Lyn M Wancket,Brad Bolon et al.
Kathleen A Funk et al.
In 2016, the publication of the Society of Toxicologic Pathology's (STP) "best practice" recommendations on determining and communicating adversity and the European Society of Toxicologic Pathology's (ESTP) expert working group report on ad...
Beyond Eye Changes in Ocular Toxicity Studies: Practical Considerations for Sampling and Evaluation of Extraocular Visual Pathways, and Common Findings [0.03%]
眼科毒性研究中的眼外视觉通路取样和评估实践及常见发现超越眼部变化
Typhaine Lejeune,Helen Booler,Joan Wicks
Typhaine Lejeune
Ocular toxicity studies may encompass a variety of ocular routes of administration. Because the retina and optic nerve are an extension of the central nervous system, safety assessment of ocular compounds must include thorough examination o...
Fabien Dachet,Jeffrey A Loeb
Fabien Dachet
A majority of the human genome codes for genes that do not produce proteins. Many of these long non-coding RNA (lncRNA) transcripts have evolved at a faster rate than genes that code for proteins, have critical regulatory and structural rol...
Meeting Report Session 3: Neurobiomarkers STP 44th Annual Symposium 2025 Development and Utility of Neurobiomarkers in Nonclinical Toxicology Studies [0.03%]
第三次会议报告：神经生物标志物第44届STP年会2025年非临床毒理学研究中神经生物标志物的开发和应用价值
Nataliya Sadekova,Typhaine Lejeune,Simone Canesi et al.
Nataliya Sadekova et al.
The objective of the third session (Neurobiomarkers) in the 2025 Society of Toxicologic Pathology (STP) symposium was to provide an overview of different types of existing neural biomarkers, highlight the value of novel biomarkers to detect...
Histology Atlas of the Developing Mouse Digestive System With Emphasis From Prenatal Day 7.5 Through Early Postnatal Development [0.03%]
小鼠消化道发育组织学图谱——从妊娠第7.5天到早生后时期的重点研究
Beth A Lubeck,Susan A Elmore,Beth Mahler et al.
Beth A Lubeck et al.
Digestive system development is a complex process, requiring precise molecular signaling interactions to produce various complex organs arising from a single primordium (the primitive gut tube). Abnormal development of this system is common...