Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Melanoma: A Systematic Review of Phase One Clinical Trials [0.03%]
治疗黑色素瘤的嵌合抗原受体T细胞疗法一期临床试验系统评价
Pavan Shet,Prerana Ghosh,Karan Varshney et al.
Pavan Shet et al.
IntroductionMelanoma is a growing health concern, with global incidence increasing annually. However, treatment for refractory disease is currently limited. Chimeric antigen receptor (CAR) T-cell therapy has shown promising results in haema...
Quantitative Histogram Analysis of 5.0T Multiparametric MRI for Discrimination Between Prostate Cancer and Benign Hyperplasia [0.03%]
基于5.0T多参数MRI的定量化直方图分析鉴别前列腺癌与良性增生病灶
Chengfeng Zheng,Sen Xing,Xinghua Liu et al.
Chengfeng Zheng et al.
IntroductionAccurate differentiation between prostate cancer (PCa) and benign prostatic hyperplasia (BPH) remains a critical diagnostic challenge with direct implications for clinical management, in part due to the inherent subjectivity of ...
CT Perfusion Blood Flow Provides an Early Response Marker for Progression-free Survival in a Prospective Randomized Clinical Trial of Metastatic Renal Cell Carcinoma [0.03%]
前瞻性随机临床试验中转移性肾细胞癌CT灌注血流量能提供无进展生存期的早期反应标志物
Chaan S Ng,Yanwen Chen,Wei Wei et al.
Chaan S Ng et al.
IntroductionThere is currently no biomarker for progression-free survival (PFS) for patients undergoing treatment for metastatic renal cell carcinoma (RCC). The aim of our study was to evaluate computed tomography perfusion (CTp) blood flow...
Randomized Controlled Trial
Technology in cancer research & treatment. 2026 Jan-Dec:25:15330338261462414. DOI:10.1177/15330338261462414 2026
Clinical Analysis of Rotational-Translational Error Coupling in 3DoF Versus 6DoF CBCT Couch Corrections:A Cross-Sectional Study [0.03%]
基于3自由度与6自由度CBCT检查床的旋转-平移误差耦合的临床分析：横断面研究
Liangbo Yi,Ke Li,Renming Zhong et al.
Liangbo Yi et al.
IntroductionThe 3-degree-of-freedom (3DOF) and 6-degree-of-freedom (6DOF) couches can enhance the accuracy of tumor localization in radiotherapy. However, the relationship between rotational and translational error corrections remains uncle...
TIPE3 in Cancer: A Multifaceted Regulator of Tumorigenesis, Therapeutic Resistance, and Clinical Outcomes [0.03%]
Tipe3在癌症中的作用：肿瘤发生、治疗抵抗和临床结局的多面调控因子
Yuling Zhang,Hui Cao,Dongran Yu et al.
Yuling Zhang et al.
TIPE3, encoded by the human TNFAIP8L3 gene, is a member of the TNFAIP8 family of lipid second-messenger transfer proteins that connects phosphoinositide signaling with cancer progression, therapeutic resistance, and clinical outcomes. Unlik...
Urine IRF4/PENK/PXDN Methylation Signatures Enable Machine Learning-Driven Bladder Cancer Detection and Microenvironment Dissection [0.03%]
基于尿液样本的机器学习驱动的膀胱癌检测及肿瘤微环境解析甲基化标志物发现
Yi He,Wenhua Xie,Wei Chen et al.
Yi He et al.
IntroductionCystoscopy-based diagnosis and surveillance of bladder cancer (BC) remain challenging. This study presents a urine-based assay that enriches DNA-methylation signals via PCR enrichment and applies a machine-learning model to enab...
The Role of High-Intensity Focused Ultrasound as a Local Consolidative Therapy in Multimodal Conversion Treatment for Colorectal Liver Metastases: A Case Series [0.03%]
高强度聚焦超声在多模式新辅助治疗结直肠癌肝转移中的局部消融作用：病例系列报告
Guangtan Du,Jiashuo Li,Junwei Wang et al.
Guangtan Du et al.
IntroductionThis retrospective case series evaluated the feasibility, safety, and potential clinical role of high-intensity focused ultrasound (HIFU) as local consolidative therapy (LCT) in patients with initially unresectable colorectal li...
Neoadjuvant Chemoimmunotherapy versus Neoadjuvant Chemoradiotherapy versus Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma: A Real-World, Three-Arm, Retrospective Cohort Study from the Chinese National Cancer Center [0.03%]
中国国家癌症中心食管鳞癌新辅助化疗免疫治疗与新辅助放化疗及新辅助化疗的回顾性三臂研究
Long Zhang,Zehang Zhang,Guochao Zhang et al.
Long Zhang et al.
IntroductionThe optimal neoadjuvant strategy for locally-advanced esophageal squamous cell carcinoma (ESCC) remains controversial. This study aimed to compare the efficacy and safety of neoadjuvant chemoimmunotherapy (NCIT), chemoradiothera...
Longitudinal MRI Temporal Transformer Fusion Model for Predicting Induction Chemotherapy Efficacy in Locally Advanced Nasopharyngeal Carcinoma [0.03%]
局部晚期鼻咽癌诱导化疗疗效预测的纵向MRI时序变换融合模型
Lei Han,Xiaoyu Chen,Zhengyu Zhao et al.
Lei Han et al.
IntroductionInduction chemotherapy (IC) represents a standard treatment approach for locally advanced nasopharyngeal carcinoma (LA-NPC), yet marked interpatient heterogeneity in treatment response persists. This study sought to develop and ...
Dose-Gradient Function-Guided Reduction of Radiation-Induced Heart Injury in Left-Sided Breast Cancer Treated With Helical Tomotherapy After Mastectomy [0.03%]
剂量梯度函数引导下的乳腺癌保乳术后的螺旋断层放射治疗以减少心脏放射损伤剂量
Yunyan Yang,Xiang Pan,Lingli Zhou et al.
Yunyan Yang et al.
IntroductionRadiation-induced heart injury (RIHI) remains an important concern in left-sided postmastectomy radiotherapy (PMRT), particularly when internal mammary lymph nodes (IMLNs) are included in the target volume. Helical tomotherapy (...