A Preliminary Study on the Auto-Segmentation of Targets and Organs at Risk in Pediatric Total Marrow and Lymphoid Irradiation [0.03%]
Zhihua Xie,Jinfeng Liu,Lixia Hou et al.
Zhihua Xie et al.
IntroductionLeukemia is one of the most prevalent cancers in children. The use of total marrow and lymphoid irradiation (TMLI) via helical tomotherapy (TOMO) as a conditioning regimen prior to bone marrow transplant (BMT) has been widely ad...
A Hybrid CNN-Transformer Deep Learning Model for Differentiating Benign and Malignant Breast Tumors Using Multi-View Ultrasound Images [0.03%]
Qi Zhang,Ruizhuo Li,Pan Tang et al.
Qi Zhang et al.
IntroductionConventional single-image analysis often fails to capture the comprehensive features of breast lesions, limiting the diagnostic accuracy of ultrasound. This study introduces a computer-aided diagnosis (CAD) system that emulates ...
Hepatic Arterial Infusion Chemotherapy Plus Systemic Chemotherapy, Lenvatinib and PD-(L)1 Inhibitors Versus Systemic Chemotherapy Plus PD-(L)1 Inhibitors in Advanced Intrahepatic Cholangiocarcinoma [0.03%]
Huazhong Guo,Yexing Huang,Na Liu et al.
Huazhong Guo et al.
IntroductionThe prognosis for unresectable intrahepatic cholangiocarcinoma (ICC) remains poor. This retrospective study aims to evaluate the efficacy and safety of HAIC combined therapy in advanced ICC.MethodsBetween April 2021 and July 202...
A Lightweight Skeletal Muscle Intelligent Segmentation Network Based on Planning CT for Cervical Cancer Radiotherapy [0.03%]
Liming Lu,Xiwei Chen,Jing Liu et al.
Liming Lu et al.
PurposeA lightweight deep learning network SMA-Net was proposed to intelligently segment the skeletal muscle of the third lumbar (L3) level in patients with cervical cancer radiotherapy, and the segmentation performance of the network was e...
IGF2BP3 Promotes Head and Neck Squamous Cell Carcinoma Progression via the M6A-LDHA-Lactate-H4K8la Axis and E2F2 Activation [0.03%]
Fan Wu,Yulu Zeng,Yunlong Hu et al.
Fan Wu et al.
IntroductionHead and neck squamous cell carcinoma (HNSCC) is characterized by metabolic reprogramming and poor prognosis. While lactate accumulates in HNSCC, how upstream RNA regulation coordinates lactate-associated epigenetic alterations ...
Focusing on the Advances and Challenges of HER2-Targeted Therapy: Cutting-Edge Breakthroughs in Neoadjuvant Treatment for HER2-Positive Breast Cancer [0.03%]
聚焦HER2靶向治疗进展与挑战：HER2阳性乳腺癌新辅助治疗前沿突破
Anqi Shang,Yunjing Xiong,Min Li et al.
Anqi Shang et al.
HER2-positive breast cancer, characterized by overexpression of the human epidermal growth factor receptor 2 (HER2), accounts for approximately 15-20% of all breast cancers and is associated with aggressive tumor behavior and poor prognosis...
Effect of Cisplatin Cycles on Prognosis for Cervical Cancer Patients Treated With Concurrent Chemoradiotherapy: A Retrospective Cohort Study [0.03%]
顺铂疗程对同步放化疗宫颈癌患者预后影响的回顾性队列研究
Zheng Zeng,Xilin Yang,Weiping Wang et al.
Zheng Zeng et al.
IntroductionTo assess the impact of cisplatin cycles on overall survival (OS) and disease-free survival (DFS) in cervical cancer (CC) patients undergoing concurrent chemoradiotherapy (CCRT), and to build a nomogram-based prognostic stratifi...
Influence of Interfractional Variations of Bladder and Rectal Filling on Vaginal Cuff Movement and the Role of Rectal Balloons in Gynecological Pelvic Proton Beam Therapy [0.03%]
膀胱和直肠充盈的体间变异对阴道 cuff 运动的影响及妇科盆腔质子治疗中直肠气球的作用
Lars Wessel,Friderike K Longarino,Natalia Sycheva et al.
Lars Wessel et al.
IntroductionPostoperative active raster-scanning intensity modulated proton beam therapy (IMPT) for gynecological cancers requires precise target coverage, yet interfractional motion of the vaginal cuff and adjacent pelvic organs may compro...
Mechanical Microenvironment-Dependent Tumor Growth Intervention: Recent Advances and Translational Outlook [0.03%]
基于机械微环境的肿瘤生长干预：最新研究进展与转化应用展望
Danjing Liang,Huan Zhou,Xinye Ni
Danjing Liang
In recent years, increasing attention has been directed toward the mechanical microenvironment, which has become a major research focus in elucidating the mechanisms underlying tumor progression. On one hand, endogenous mechanical cues, suc...
A Clinical-Radiomics Nomogram Predicts Early Tumor Necrosis After Transarterial Chemoembolization for Hepatocellular Carcinoma [0.03%]
一种临床-影像组学列线图预测肝细胞癌经导管动脉化疗栓塞治疗后早期肿瘤坏死
Xiang-Ling Wu,Bing-Zhi Duan,Zhi-Hua Jiang et al.
Xiang-Ling Wu et al.
IntroductionWe introduce a standardized necrosis rate-percent reduction in enhancing tumor diameter normalized by baseline tumor diameter-with a threshold of ≥30%. This endpoint is derived from the mRECIST partial response criteria but is ...