Glucose metabolism and neurological outcome in congenital hyperinsulinism [0.03%]
先天性高胰岛素血症的葡萄糖代谢与神经预后关系的研究
Anja Ludwig,Katja Ziegenhorn,Susann Empting et al.
Anja Ludwig et al.
Advances in imaging and surgical techniques allow a complete cure for children with focal-type congenital hyperinsulinism (CHI). In contrast, management of diffuse-type CHI remains a matter of controversy. To prevent hypoglycemic brain dama...
Multicenter Study
Seminars in pediatric surgery. 2011 Feb;20(1):45-9. DOI:10.1053/j.sempedsurg.2010.10.005 2011
Jan Marquard,Andrew A Palladino,Charles A Stanley et al.
Jan Marquard et al.
Rare forms of congenital hyperinsulinism (CHI) are caused by mutations in GLUD1 (encoding glutamate dehydrogenase), GCK (encoding glucokinase), HADH (encoding for L-3-hydroxyacyl-CoA dehydrogenase), SLC16A1 (encoding the monocarboxylat tran...
A specialized team approach to diagnosis and medical versus surgical treatment of infants with congenital hyperinsulinism [0.03%]
特发队列的方法对先天性高胰岛素血症婴儿进行诊断以及医学和手术治疗的比较
Andrew A Palladino,Charles A Stanley
Andrew A Palladino
Hyperinsulinism (HI) is the most common cause of transient and permanent forms of hypoglycemia in infancy. Establishing the correct diagnosis and initiating appropriate therapy without delay is of utmost importance. Once the diagnosis is ma...
Visualization of the focus in congenital hyperinsulinism by intraoperative sonography [0.03%]
术中超声波检查用于先天性高胰岛素血症病变定位的价值评估
Ludwig von Rohden,Klaus Mohnike,Harald Mau et al.
Ludwig von Rohden et al.
In surgery for focal congenital hyperinsulinism (CHI), the identification and complete resection of the focus without collateral damage is of utmost importance. In a pilot study we applied intra-abdominal high-frequency sonography during su...
Positron emission tomography/computed tomography diagnostics by means of fluorine-18-L-dihydroxyphenylalanine in congenital hyperinsulinism [0.03%]
氟-18-L-二氢苯丙氨酸正电子发射体层摄影/计算机体层摄影在先天性高胰岛素血症诊断中的应用
Wolfgang Mohnike,Winfried Barthlen,Klaus Mohnike et al.
Wolfgang Mohnike et al.
The unfavorable prognosis of congenital hyperinsulinism (CHI) can be avoided if the patients are treated with high-dose glucose infusions and timely surgical intervention. Circumscribed foci used to be identified by selective percutaneous p...
Cécile Saint-Martin,Jean-Baptiste Arnoux,Pascale de Lonlay et al.
Cécile Saint-Martin et al.
Adenosine triphosphate (ATP)-sensitive potassium channels (K(ATP) channels) have a central role in the regulation of insulin secretion in pancreatic β cells. They are octameric complexes organized around the central core constituted by the...
Sarah E Flanagan,Ritika R Kapoor,Khalid Hussain
Sarah E Flanagan
A genetic diagnosis is now possible for approximately 45%-55% of patients with hyperinsulinemic hypoglycemia. Understanding the genetic etiology of the disease in these patients is clinically important because a genetic diagnosis will provi...
Morphologic analysis of focal and diffuse forms of congenital hyperinsulinism [0.03%]
先天性高胰岛素血症局灶性和弥漫性病变的组织病理学特点分析
Jacques Rahier,Yves Guiot,Christine Sempoux
Jacques Rahier
Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. Nesidioblastosis, the proliferation of islet cells budding off from ducts, has been considered for year...
Congenital hyperinsulinism [0.03%]
先天性高胰岛素血症
Winfried Barthlen,Pascale de Lonlay
Winfried Barthlen
Barbara A Gaines,John D Rutkoski
Barbara A Gaines
Minimally invasive techniques have now become standard for the treatment of many surgical conditions in children. During the past decade, there has been increasing interest in the use of this technology for the management of injured childre...