Prognostic significance and therapeutic potential of pyroptosis in gynecological malignancies [0.03%]
Zhen Wei,Hui-Hui Liu,Yu Yun et al.
Zhen Wei et al.
Background: Pyroptosis, an inflammatory form of programmed cell death, has emerged as a critical regulator of tumor biology. Its prognostic value in gynecologic malignancies remains unclear. ...
Ferroptosis in ovarian cancer: Regulation, immunity, and therapeutic potential with the tumor microenvironment [0.03%]
卵巢癌中铁死亡的调控、免疫和与肿瘤微环境相互作用的治疗潜力
Ruhe Jiang,Yue Yu,Jun Guan et al.
Ruhe Jiang et al.
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, represents a pivotal and translationally promising target in ovarian cancer management. This review systematically explores the dual role of ferroptos...
Advances in the management of metastatic lobular breast cancer: Current evidence and emerging treatments [0.03%]
转移性乳腺癌的治疗进展：现有证据和新兴疗法
Ana Isabel Martín-Quesada,Carla Martín-Abreu
Ana Isabel Martín-Quesada
Invasive lobular carcinoma (ILC) comprises ∼10%-15% of breast cancers and is characterized by loss of the cell-adhesion molecule E-cadherin (encoded by CDH1), discohesive growth, predominant estrogen receptor (ER) positivity, low-to-interm...
DNA methylation-mediated extracellular matrix gene silencing in colorectal cancer [0.03%]
结肠直肠癌中DNA甲基化介导的细胞外基质基因沉默作用
Otília Menyhart,Dalma Müller,Balázs Győrffy
Otília Menyhart
Epigenetic alterations, particularly DNA methylation, play a crucial role in colorectal cancer (CRC) development and progression. We aimed to investigate DNA methylation changes across normal colon samples, adenomas, and adenocarcinomas to ...
Artificial intelligence in gynecologic oncology: A cautionary look in the Indian context [0.03%]
妇科肿瘤领域的人工智能：印度视角的审慎观察
Sarita Kumari,Rudrika Chandra,Abhinav Tiwari
Sarita Kumari
Artificial intelligence (AI) is making remarkable strides in the field of oncology. The potential is humongous, but the perils are understated. From the perspective of gynecologic oncologists from India, we urge everyone to take a cautionar...
Amr Ali Mohamed Abdelgawwad El-Sehrawy,Mohammad Y Alshahrani,Muzdalifa Mejbel Fedwi et al.
Amr Ali Mohamed Abdelgawwad El-Sehrawy et al.
Melanoma, a highly aggressive type of skin cancer, has undergone incredible developments in immunotherapy, particularly in modulating T-cell immunity. T cells are essential components of the antitumor immune response and can undoubtedly inf...
Submicron silica particles drives prostate cancer aggressiveness via lipid-metabolic reprogramming [0.03%]
亚微米级硅颗粒通过脂质代谢谱重编程促进前列腺癌的恶性发展
Pengpeng Su,Qianfeng Xu,Yan Wang et al.
Pengpeng Su et al.
Micron-sized (1 µm - 100 µm) and submicron-sized (100 nm-1 µm) silica particles are prevalent in both natural environments and areas influenced by human activities. Their environmental forms, origins, and pathways of human exposure diffe...
Targeting TRP channels in oral cancer: Mechanistic potential and therapeutic promise [0.03%]
口腔癌中靶向TRP通道的潜在机制和治疗前景
Kaviyarasi Renu,Vishnu Priya Veeraraghavan,Harishkumar Madhyastha
Kaviyarasi Renu
Oral cavity cancer remains a major clinical challenge due to its aggressive nature, rapid lymphatic spread, and limited therapeutic options. Despite advancements in diagnosis and treatment, patient prognosis continues to be poor, highlighti...
UBE2T promotes papillary thyroid carcinoma progression by activating the JAK/STAT3 pathway via negative regulation of SOCS2 [0.03%]
UBE2T通过抑制SOCS2激活JAK/STAT3通路促进乳头状甲状腺癌进展
Lijun Zhang,Chengyuan Li,Jianing Zhou et al.
Lijun Zhang et al.
Papillary thyroid carcinoma (PTC) exhibits aggressive behaviors such as tumor invasion and lymph node metastasis that critically influence prognosis, yet reliable predictors of invasiveness remain elusive. This study investigated the molecu...
The role of circular RNAs in driving cancer advancement in low-oxygen conditions [0.03%]
circRNA在低氧条件下驱动癌症发展的机制研究进展
Hamza Abu Owida,Raed Obaid Saleh,Suleiman Ibrahim Mohammad et al.
Hamza Abu Owida et al.
Oxygen shortage, or hypoxia, is a unifying feature of solid tumors that broadly characterizes cancer biology and therapeutic outcome. In expanding tumors, cells adapt to low oxygen tensions by undergoing extensive metabolic reorganization, ...