Immune-driven clonal cell selection at the intersection among cancer, infections, autoimmunity and senescence [0.03%]
处于癌症、感染、自免疫和衰老交叉点上的免疫驱动的克隆细胞选择
Simona Pagliuca,Francesca Ferraro
Simona Pagliuca
Immune surveillance mechanisms play a crucial role in maintaining lifelong immune homeostasis in response to pathologic stimuli and aberrant cell states. However, their persistence, especially in the context of chronic antigenic exposure, c...
CD19 CAR-T cell therapy for relapsed or refractory diffuse large B cell lymphoma: Why does it fail? [0.03%]
CD19 CAR-T细胞治疗复发或难治性弥漫大B细胞淋巴瘤的失败原因是什么？
Hannah Kinoshita,Catherine M Bollard,Keri Toner
Hannah Kinoshita
Chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed or refractory diffuse large B cell lymphoma (DLBCL) with 3 CD19 targeting products now FDA-approved for this indication. However, up to 60% of patients ...
Sonali M Smith,Laura Pasqualucci
Sonali M Smith
Katharine L Lewis,Judith Trotman
Katharine L Lewis
F-fluorodeoxyglucose positron emission tomography-computerized tomography (18FDG-PET/CT) is the gold-standard imaging modality for staging and response assessment for most lymphomas. This review focuses on the utility of 18FDG-PET/CT, and i...
Enrico Attardi,Seth J Corey,Marcin W Wlodarski
Enrico Attardi
Clonal hematopoiesis in children and young adults differs from that occuring in the older adult population. A variety of stressors drive this phenomenon, sometimes independent of age-related processes. For the purposes of this review, we ad...
Yasuo Kubota,Aaron D Viny
Yasuo Kubota
Clonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent overrepresentation of cells from a common stem/progenitor lineage harboring single-nucleotide variants and/or insertions/deletions. CH is a common and...
Elizabeth R Francis,Jennifer Vu,Catherine Ostos Perez et al.
Elizabeth R Francis et al.
Chronic lymphocytic leukemia (CLL) is characterized by immune dysfunction resulting in heightened susceptibility to infections and elevated rates of morbidity and mortality. A key strategy to mitigate infection-related complications has bee...
Transforming CLL management with immunotherapy: Investigating the potential of CAR T-cells and bispecific antibodies [0.03%]
免疫疗法在CLL管理中的应用转变：探究CAR T细胞和双特异性抗体的潜力
Azra Borogovac,Tanya Siddiqi
Azra Borogovac
Immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies or T-cell engagers, have revolutionized the treatment landscape for various B-cell malignancies, including B-acute lymphoblastic leukemia and ...
B-cell receptor immunoglobulin stereotypy in chronic lymphocytic leukemia: Key to understanding disease biology and stratifying patients [0.03%]
慢性淋巴细胞白血病中B细胞受体免疫球蛋白的类同性：了解疾病生物学和分层患者的关键
Andreas Agathangelidis,Thomas Chatzikonstantinou,Kostas Stamatopoulos
Andreas Agathangelidis
Sequence convergence, otherwise stereotypy, of B-cell receptor immunoglobulin (BcR IG) from unrelated patients is a distinctive feature of the IG gene repertoire in chronic lymphocytic leukemia (CLL) whereby patients expressing a particular...
Sophia S Wang
Sophia S Wang
As the most common non-Hodgkin lymphoma subtype, diffuse large B-cell lymphoma (DLBCL) incidence patterns generally parallel that for NHL overall. Globally, DLBCL accounts for a third of all NHLs, ranging between 20% and 50% by country. Bas...