Olufunke Y Martin,Deepika S Darbari
Olufunke Y Martin
Pain is the most common complication experienced by individuals living with sickle cell disease (SCD). While episodes of acute pain, also known as vaso-occlusive crises, are the hallmark of the disease, chronic pain is prevalent in SCD and ...
Thomas d&#x;Humières,Sylvain Le Jeune,Gonzalo de Luna et al.
Thomas d&#x;Humières et al.
Sickle cell disease (SCD) is a systemic vasculopathy, which progressively remodels the heart and pulmonary circulation through chronic anemia, hemolysis, and endothelial dysfunction. This review integrates current evidence on the mechanisms...
Clonal hematopoiesis in the setting of sickle cell disease and its relevance to curative therapies [0.03%]
镰状细胞病背景下的克隆血细胞生成及其对根治性治疗的意义
Lachelle D Weeks
Lachelle D Weeks
Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic hemolytic anemia, painful vaso-occlusive episodes, and end-organ damage. Population-level studies indicate individuals with SCD are at an increased risk for...
Treatment of myeloproliferative neoplasms: Exploring new horizons of who and when to cytoreduce in patients with polycythemia vera and essential thrombocytosis [0.03%]
我的增生性肿瘤的治疗：探索在原发性血小板增多症和真性红细胞增多症患者中进行细胞还原治疗的新视野及时机
Katherine J Feder,Gabriela S Hobbs
Katherine J Feder
Treatment for the classical Philadelphia-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV) and essential thrombocythemia (ET), has long relied on reducing thrombotic risk without a focus on underlying disease mo...
Emma M Groarke,Fernanda Gutierrez-Rodrigues
Emma M Groarke
Cardiovascular complications in patients with myeloproliferative neoplasms: What hematologists need to know [0.03%]
我的血液学并发症：血细胞增生异常患者的血管并发症
Orly Leiva,Olivia C Liu,Monica Ferrante et al.
Orly Leiva et al.
Patients with myeloproliferative neoplasms (MPNs), including essential thrombocythemia, polycythemia vera, and myelofibrosis, are at increased risk of cardiovascular disease and complications. The most recognized cardiovascular complication...
Evolving insights into mitochondrial presence in RBC in sickle cell disease: Red blood cell and reticulocyte pathophysiology, therapeutic strategies, and future directions [0.03%]
镰状细胞病中红细胞和网织红细胞病理生理、治疗策略及未来方向的最新认识：关于红细胞线粒体存在的新见解
Yaw Ansong-Ansongton,Daisy Zapet Bamac,Angela Rivers
Yaw Ansong-Ansongton
Recent advances in understanding sickle cell disease (SCD) pathophysiology have revealed the critical role of abnormal mitochondrial retention in mature erythrocytes. This comprehensive review examines how disrupted mitochondrial clearance ...
Randolph B Lyde,Enrico M Novelli
Randolph B Lyde
With the growing interest in precision medicine and personalized treatments for sickle cell disease (SCD) comes a realization that our approach to individuals living with the hemoglobin SC (HbSC) genotype is inadequate. For many decades HbS...
John Gibson,Rasiqh Wadud,Pengyi Ding et al.
John Gibson et al.
Sickle cell patients with HbSC genotype represent the second commonest form of sickle cell disease (SCD) amongst people of African origin. HbSC cells are markedly shrunken. Although containing only about half the amount of HbS as red cells ...
Sana A Pirzada,Wesam Aleyadeh,Sawsan Fathma et al.
Sana A Pirzada et al.
Telomere biology disorders (TBDs) are rare inherited conditions caused by defects in telomere maintenance genes, leading to premature cellular aging and multisystem disease. The liver is the third most affected organ after the bone marrow a...