Mallorie B Heneghan,Jennifer A Belsky,Sarah A Milgrom et al.
Mallorie B Heneghan et al.
Hodgkin lymphoma (HL) occurs throughout the lifespan but is one of the most common cancers in adolescents and young adults (AYA; 15-39 years). HL has become a highly curable disease with survival rates surpassing 90%, including patients wit...
Alessia Floerchinger,Martina Seiffert
Alessia Floerchinger
The Eµ-TCL1 mouse model has been used for over 20 years to study the pathobiology of chronic lymphocytic leukemia (CLL) and for preclinical testing of novel therapies. A CLL-like disease develops with increasing age in these mice due to a ...
Samuel Kosydar,Stephen M Ansell
Samuel Kosydar
Classical Hodgkin lymphoma (cHL) is distinguished by several important biological characteristics. The presence of Hodgkin Reed Sternberg (HRS) cells is a defining feature of this disease. The tumor microenvironment with relatively few HRS ...
The complexities of T-cell dysfunction in chronic lymphocytic leukemia [0.03%]
慢性淋巴细胞性白血病T细胞功能障碍的复杂性
Elena Camerini,Derk Amsen,Arnon P Kater et al.
Elena Camerini et al.
Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by profound alterations and defects in the T-cell compartment. This observation has gained renewed interest as T-cell treatment strategies, which are successfully appli...
Mouse models of CLL: In vivo modeling of disease initiation, progression, and transformation [0.03%]
慢性淋巴细胞白血病的小鼠模型：疾病发生、发展及转化的体内建模
Shih-Shih Chen
Shih-Shih Chen
Chronic lymphocytic leukemia (CLL) is a highly complex disease characterized by the proliferation of CD5+ B cells in lymphoid tissues. Current modern treatments have brought significant clinical benefits to CLL patients. However, there are ...
Targeting the B cell receptor signaling pathway in chronic lymphocytic leukemia [0.03%]
慢性淋巴细胞白血病的B细胞受体信号通路靶向疗法
John T Patton,Jennifer A Woyach
John T Patton
Aberrant signal transduction through the B cell receptor (BCR) plays a critical role in the pathogenesis of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). BCR-dependent signaling is necessary for the growth and surviva...
Recep Bayraktar,Beatrice Fontana,George A Calin et al.
Recep Bayraktar et al.
microRNAs (miRNAs) are a class of small non-coding RNAs that play a crucial regulatory role in fundamental biological processes and have been implicated in various diseases, including cancer. The first evidence of the cancer-related functio...
Special issue on chronic lymphocytic leukemia: Prognostication and therapeutic options introductory editorial [0.03%]
慢性淋巴细胞白血病：预后和治疗选择的专题报道——介绍性评论文章
Barbara Eichhorst,Elisa Ten Hacken
Barbara Eichhorst
Inhye E Ahn,Matthew S Davids
Inhye E Ahn
Therapeutic targeting of apoptosis with small molecule B-cell lymphoma 2 (BCL-2) inhibition with venetoclax is highly efficacious in CLL, leading to sustained deep responses, particularly among patients with treatment-naïve disease with fa...
Riccardo Moia,Gianluca Gaidano
Riccardo Moia
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries. CLL is a highly heterogeneous disease: some patients may never require therapy and others relapse several times after different therapeutic strateg...