Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study [0.03%]
代谢综合征与银屑病发病风险增加相关——一项基于全国人群的调查研究
Ha-Na Kim,Kyungdo Han,Yong-Gyu Park et al.
Ha-Na Kim et al.
Background: Psoriasis is a chronic inflammatory skin disease characterized by an abnormal T-cell-mediated immune response, and is associated with metabolic syndrome (MetS) and components thereof. However, few prospective ...
Laparoscopic sleeve gastrectomy reverses non-alcoholic fatty liver disease modulating oxidative stress and inflammation [0.03%]
腹腔镜胃袖状切除术通过调节氧化应激和炎症来逆转非酒精性脂肪肝病
Noemí Cabré,Fedra Luciano-Mateo,Salvador Fernández-Arroyo et al.
Noemí Cabré et al.
Background & aims: Hepatic alterations, such as in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are frequently associated with obesity. To investigate the molecular mechanisms of thes...
Incretin-based medications (GLP-1 receptor agonists, DPP-4 inhibitors) as a means to avoid hypoglycaemic episodes [0.03%]
以胰高血糖素样肽-1受体激动剂和二肽基肽酶Ⅳ抑制剂为基础的药物治疗作为避免低血糖事件的一种手段
Johan Farngren,Bo Ahrén
Johan Farngren
Hypoglycaemia is common in both type 1 and type 2 diabetes and has both acute and long-term consequences. Therefore, a key to proper glucose-lowering therapy in diabetes is to avoid or prevent hypoglycaemia. Incretin therapy (DPP-4 inhibito...
Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis [0.03%]
内质网压力激活G0 / G1开关基因2可增强肝脂肪变性
Yunqin Ma,Mingliang Zhang,Haoyong Yu et al.
Yunqin Ma et al.
Background: Perturbed endoplasmic reticulum (ER) homeostasis and increased levels of G0/G1 Switch Gene 2 (G0S2) have been documented in animal models with fatty liver disease. In this study, we investigated whether G0S2 i...
Modulation of brain activity by hormonal factors in the context of ingestive behaviour [0.03%]
激素在摄食行为背景下对脑活动的调节作用
Janis Marc Nolde,Jana Laupenmühlen,Arkan Al-Zubaidi et al.
Janis Marc Nolde et al.
Introduction: Metabolic and hormonal signals have been shown to be associated with brain activity in the context of ingestive behaviour. However, this has mostly been seen in studies using external administration of hormo...
Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans [0.03%]
短期泼尼松治疗对健康人腹部脂肪组织脂解和脂肪酶信号指标的影响
Nilani Ramshanker,Niels Jessen,Thomas Schmidt Voss et al.
Nilani Ramshanker et al.
Background: Glucocorticoid (GC) excess increases lipolysis, circulating free fatty acid concentrations and lipid oxidation rates in humans. In vitro and animal studies have shown that GCs increase adipocyte ATGL and HSL m...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2019 Oct:99:1-10. DOI:10.1016/j.metabol.2019.06.013 2019
Initial injectable therapy in type 2 diabetes: Key considerations when choosing between glucagon-like peptide 1 receptor agonists and insulin [0.03%]
2型糖尿病患者起始注射治疗：选择胰高血糖素样肽-1受体激动剂或基础胰岛素时需考虑的关键问题
Anastasia-Stefania Alexopoulos,John B Buse
Anastasia-Stefania Alexopoulos
Managing type 2 diabetes is complex and necessitates careful consideration of patient factors such as engagement in self-care, comorbidities and costs. Since type 2 diabetes is a progressive disease, many patients will require injectable ag...
Amino acid signature predictive of incident prediabetes: A case-control study nested within the longitudinal pathobiology of prediabetes in a biracial cohort [0.03%]
一项关于糖尿病前期的病例对照研究：嵌套在两族系队列人群纵向糖尿病前病程生物学研究中的氨基酸特征标志物预测糖尿病前期发病
Ibiye Owei,Nkiru Umekwe,Frankie Stentz et al.
Ibiye Owei et al.
Objective: Circulating branched-chain amino acids (BCAAs, isoleucine, leucine, valine) and aromatic amino acids (AAAs, tyrosine and phenylalanine) predicted type 2 diabetes mellitus (T2DM) risk in a Caucasian population. ...
New developments in our understanding of vitamin metabolism, action and treatment [0.03%]
维生素代谢、作用和治疗研究的新进展
Sylvia Christakos,Shanshan Li,Jessica De La Cruz et al.
Sylvia Christakos et al.
Although vitamin D has been reported to have pleiotropic effects including effects on the immune system and on cancer progression, the principal action of vitamin D is the maintenance of calcium and phosphate homeostasis. The importance of ...
Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle [0.03%]
人类骨骼肌脂质应激下过氧化物酶体基因和蛋白质表达上调响应机制研究
Tai-Yu Huang,Donghai Zheng,Robert C Hickner et al.
Tai-Yu Huang et al.
Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function results in neonatal death. Little is known about how peroxisomal content and activity respond to changes in the lipid environment in human skeletal ...