Fei Zhang,Zhong Wang
Fei Zhang
ASGR1 exacerbates MASLD by inducing hepatocyte senescence via lysosomal dysfunction and HIF-1α stabilization [0.03%]
Chen-Yu Zhang,Jie Ding,Yi-Jia Sun et al.
Chen-Yu Zhang et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease with limited therapeutic options. Hepatocyte senescence is a critical driver of MASLD progr...
Mesenchymal stem cell therapy for diabetes: clinical evidence, emerging strategies, and future perspectives [0.03%]
Han-Ying Jhuang,Jo-Yu Lee,Li-Tzu Wang
Han-Ying Jhuang
Diabetes mellitus (DM) is a multifactorial metabolic disorder in which chronic hyperglycemia arises alongside adipose-tissue dysfunction, ectopic lipid accumulation, endothelial injury, and progressive multiorgan damage. These processes for...
Alpha-ketoglutarate ameliorates diabetes-associated skeletal muscle fibrosis by restoring TET2-dependent epigenetic remodeling in CD90 positive fibro-adipogenic progenitors [0.03%]
α-酮戊二酸通过恢复CD90阳性成脂祖细胞中TET2依赖性表观遗传重编程来改善糖尿病相关骨骼肌纤维化
Zhou-Jie Tong,Yi-Hui Li,Ming Song et al.
Zhou-Jie Tong et al.
Objective: Fibro-adipogenic progenitor (FAP) dysfunction drives skeletal muscle fibrosis in type 2 diabetes mellitus (T2DM), yet the underlying metabolic-epigenetic mechanisms remain poorly understood. This study investig...
HSF1-UCHL1 transcriptional axis protects against MASLD via regulation of PPARα protein stability [0.03%]
HSF1-UCHL1转录轴通过调节PPARα蛋白稳定性抵抗MASLD
Yuxiang Cao,Xiangcheng Fan,Meiyao Meng et al.
Yuxiang Cao et al.
Background & aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic liver diseases in modern society. Heat shock factor 1 (HSF1) is a transcription factor that orchestr...
Serine synergizes with lipopolysaccharide to induce macrophage pyroptosis through extracellular Hsp90α and early skin immune microenvironment disruption in diabetic foot [0.03%]
丝氨酸通过细胞外Hsp90α诱导脂多糖协同诱导巨噬细胞pyroptosis及早期皮肤免疫微环境紊乱在糖尿病足中的作用
Shuxian Li,Mengyi Cai,Liwen Chen et al.
Shuxian Li et al.
Background: The pathogenesis of early-stage skin lesions in diabetic foot (DF) remains poorly understood, and cannot be fully explained by conventional theories. Skin microbiota dysbiosis has recently emerged as a critica...
Apolipoprotein M: A liver-derived lipid-binding protein protects against heart failure with preserved ejection fraction by inhibiting TGF-β signaling [0.03%]
载脂蛋白M通过抑制TGF-β信号途径对抗射血分数保留性心力衰竭
Hong Yang,Shuai Mei,Yi He et al.
Hong Yang et al.
Background: Visceral and hepatic adiposity and associated inflammation are recognized as prominent features of heart failure (HF) with preserved ejection fraction (HFpEF). Apolipoprotein M (ApoM), a liver-derived lipid-bi...
Glutamine synthetase deficiency triggers mitochondrial oxidative stress and a ribotoxic stress response during acute hepatic metabolic crisis [0.03%]
谷氨酰胺合成酶缺乏在急性肝代谢危象时触发线粒体氧化应激和核糖毒应力反应
Guihua Jin,Chengcheng Lin,Yamei Wei et al.
Guihua Jin et al.
Background & aims: Chlorfenapyr (CHL) is associated with high acute lethality in humans, with a case fatality rate exceeding 80%. However, the mechanisms underlying its hepatotoxicity remain poorly understood. ...
MDM2 deletion and its associated p53 activation in subcutaneous white adipose tissue induce hepatic fibrosis via galectin-3 in a mouse model [0.03%]
MDM2基因敲除和其诱导的皮下白色脂肪组织p53活化通过半乳糖凝集素-3诱导小鼠肝纤维化
Pujie Liu,KeKao Long,Yi Wang et al.
Pujie Liu et al.
Background: White adipose tissue (WAT) communicates with distal metabolic organs and regulates their functions by secreting adipokines. Subcutaneous WAT (sWAT) is thought to be metabolically protective but prone to dysfun...
Adipocyte caspase-1 deficiency promotes white fat beiging via COX7A2L-dependent mitochondrial respiration [0.03%]
脂肪细胞Caspase-1缺乏通过COX7A2L依赖性线粒体呼吸促进白色脂肪棕色化
Yumeng Wang,Jiajie Li,Weijiong He et al.
Yumeng Wang et al.
Beiging of white adipose tissue (WAT) is a promising strategy to enhance energy expenditure and combat obesity, a growing global health burden. Here, we identify a non-canonical role of caspase-1, a cysteine protease, in regulating adipocyt...