SEC62 at mitochondria-associated membranes drives MASH progression by suppressing ATAD3B-mediated mitochondrial quality control [0.03%]
Junchao Lin,Tong Wu,Chen Wang et al.
Junchao Lin et al.
Background: The progression of metabolic dysfunction-associated steatohepatitis (MASH) involves chronic, irreversible inflammatory responses linked to intracellular organelle dysfunction. While endoplasmic reticulum (ER) ...
Huiying Wang,Wen-Yue Liu,Feng Zhang et al.
Huiying Wang et al.
Background & aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease with limited therapeutic options, and the role of ferroptosis in its pathogenesis remains to be fully understood. I...
Skeletal muscle-derived Metrnl induced by exercise displays the roles of endothelioprotective and anti-atherosclerosis in male mice through KIT/NFκB signaling [0.03%]
运动诱导的骨骼肌源性Metrnl在雄性小鼠中通过KIT/NFκB信号通路发挥内皮保护和抗动脉粥样硬化作用
Jinlian Li,Xiangyan Peng,Chen Huang et al.
Jinlian Li et al.
Objective: The mechanisms by which skeletal muscle activity during exercise state modulates vascular function and atherosclerosis remain poorly understood. The aim of this study was to investigate the function of skeletal...
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3: A potential target in the development of diabetes and its complications [0.03%]
果糖-2,6-二磷酸酶3在糖尿病及其并发症发展中的作用与机制研究
Minmin Jiang,Xiaofei An
Minmin Jiang
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is a bifunctional enzyme involved in the production and breakdown of fructose-2,6-bisphosphate (F-2,6-BP) and serves as a key regulator of glucose metabolism. It is closely impl...
Circadian robustness and glycemic control: From wearable data to clinical implications [0.03%]
昼夜节律稳健性与血糖控制：从可穿戴设备数据到临床意义
Guobin Guobin Liu,Xin Yuan
Guobin Guobin Liu
Loss of cardiomyocyte AKT signaling causes deterioration of lipid metabolism and cellular atrophy [0.03%]
心肌细胞AKT信号丧失导致脂质代谢恶化和细胞萎缩
Stefanie Gödecke,André Heinen,Tim Appel et al.
Stefanie Gödecke et al.
The mammalian heart critically depends on oxidative metabolism of fatty acids, glucose, ketones, and amino acids to meet its extensive ATP demands. AKT/protein kinase B plays a central role in regulating cell growth and metabolism by coordi...
When the proteome meets the metabolome observational and Mendelian randomization analyses [0.03%]
蛋白质组遇到代谢组：观察分析和孟德尔随机化分析
Rui Zheng,Mario Delgado-Velandia,Johan Ärnlöv et al.
Rui Zheng et al.
Objective: The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess t...
Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation [0.03%]
二甲双胍通过抑制蛋白质翻译来抑制内质网应激下的β细胞凋亡
Ryota Inoue,Kazuki Tajima,Tomoko Okuyama et al.
Ryota Inoue et al.
Endoplasmic reticulum (ER) stress is a critical driver of pancreatic β-cell dysfunction and apoptosis. Although metformin, a drug used to treat type 2 diabetes, primarily decreases blood glucose levels by improving insulin sensitivity, its...
GLP-1 receptor agonists and atrial fibrillation: Chronotropy, atrial substrate, and cardiometabolic mechanisms [0.03%]
胰高血糖素样肽1受体激动剂与房颤：心率、心房重构和 cardio-metabolic 机制
Paschalis Karakasis,Nikolaos Fragakis,Konstantinos Vlachos et al.
Paschalis Karakasis et al.
Reply to letter to the editor: Circadian robustness and glycemic control: From wearable data to clinical implications [0.03%]
关于编辑来信的回复：节律稳健性与血糖控制：从可穿戴设备数据到临床意义
Da Young Lee,Jung-Been Lee,Inha Jung et al.
Da Young Lee et al.