Cardiovascular health factors and altered proteomic landscapes in the progression of cardiovascular-kidney-metabolic syndrome: Evidence from multi-cohorts in China, the UK, and the US [0.03%]
Erxu Xue,Jianhui Zhao,Bowen Chen et al.
Erxu Xue et al.
Background: The role of cardiovascular health (CVH) factors and their associated proteomic profiles in the progression and prognosis of cardiovascular-kidney-metabolic (CKM) syndrome among individuals at stages 0-3 remain...
Linghua Fu,Rui Ding,Gaosi Xu et al.
Linghua Fu et al.
The global escalation of obesity necessitates therapeutic interventions that transcend the efficacy ceilings of current mono-target pharmacotherapies. Amycretin, a novel unimolecular co-agonist targeting glucagon-like peptide-1 (GLP-1) and ...
An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding [0.03%]
Cunjin Su,Jing Cai,Yuanzhong Xu et al.
Cunjin Su et al.
Homeotherms maintain a steady body temperature through thermoregulation, a process critical for survival during fasting, in which the brain has to defend energy-costly body temperature while reducing energy expenditure to conserve energy re...
PDAP1 reprograms fatty acid metabolism and drives malignant transformation via HSPA8-Mediated ERK/MAPK activation in hepatocellular carcinoma [0.03%]
Jiazheng Li,Xiangxu Kong,Huaibin Sun et al.
Jiazheng Li et al.
Aims: Hepatocellular carcinoma (HCC) exhibits aberrant lipid metabolism, notably increased de novo fatty acid synthesis and reduced fatty acid oxidation. PDAP1, a cancer-associated RNA-binding protein, is overexpressed in...
Adipose tissue catecholamine resistance: a metabolic safeguard that challenges weight control [0.03%]
脂肪组织儿茶酚胺抵抗性：一种代谢保护机制对体重控制的挑战
Lucio Della Guardia,Andrew C Shin
Lucio Della Guardia
Catecholamine resistance in adipose tissue encompasses an articulated network of cellular and molecular adaptations to inflammatory and neuroendocrine signals in obesity. By dampening adrenergic signaling, these adaptations may serve a prot...
Mapping circulating microRNA signatures in type 1 diabetic microvascular disease: A systematic review and Bayesian multilevel meta-analysis with bioinformatic integration of molecular dysregulation [0.03%]
糖尿病微血管病变中循环microRNA谱的系统性综述及生物信息学分子异常调控整合分析
Yousef Khadivi,Pardis Tavallaeinejad,Mahin Hashemipour et al.
Yousef Khadivi et al.
Background: To systematically evaluate microRNAs (miRNAs) associated with microvascular complications of type 1 diabetes mellitus (T1D), quantify differential expression using complementary frequentist and Bayesian meta-a...
Once-weekly insulin GZR4 versus once-daily insulin degludec in Chinese people with type 2 diabetes: A multicenter, open-label, randomized, phase 2 trial [0.03%]
一项在中国2型糖尿病患者中比较一周一次甘精胰岛素利司格列汀固定剂量复方制剂与每日一次德谷胰岛素疗效的多中心、开放标签、随机、II期临床试验
Liming Chen,Xiaolin Dong,Qiumei Zhang et al.
Liming Chen et al.
Background: Insulin GZR4 (GZR4) is a once-weekly insulin currently under development. This phase 2 trial assessed the efficacy and safety of once-weekly (QW) GZR4 versus once-daily (QD) insulin degludec (IDeg) in Chinese ...
Clifford J Bailey,Michael Gwilt,Kerstin M G Brand
Clifford J Bailey
Metformin (dimethyl biguanide) is a primary pharmacotherapy to treat hyperglycemia in type 2 diabetes. It counters the effects of insulin resistance, improves glucose homeostasis, assists weight control and avoids overt hypoglycemia via red...
CSRP3 promotes skeletal muscle remodeling toward aerobic metabolism and enhances exercise endurance through increasing LDHD activity [0.03%]
CSRP3通过增加LDHD活性促进骨骼肌向有氧代谢重塑并增强运动耐力
Xiuying Jiang,Zhaolu Wang,Rui Li et al.
Xiuying Jiang et al.
Exercise performance and skeletal muscle homeostasis are influenced by myofiber type composition. Cysteine and glycine-rich protein 3 (CSRP3) is highly expressed in the oxidative fiber-rich mammalian soleus muscle. However, the mechanistic ...
Gallein targets AMPK in AgRP neurons: A new anti-obesity hypothalamic strategy? [0.03%]
抑肥胖新策略：瓜氨酸抑制下丘脑AgRP神经元的AMPK信号通路？
Miguel López,Christos S Mantzoros
Miguel López