Alain Combes,Guillaume Franchineau
Alain Combes
Air pollution affects 90% of the world's population and has caused 9 million deaths in 2015, becoming the most important cause of premature deaths in the world. Exposure to fine particulate matter, a major component of urban air pollution, ...
Morphological and functional adaptations of pancreatic alpha-cells during late pregnancy in the mouse [0.03%]
小鼠晚期妊娠期间胰腺α细胞的形态和功能适应性变化
Cristina Quesada-Candela,Eva Tudurí,Laura Marroquí et al.
Cristina Quesada-Candela et al.
Background: Pregnancy represents a major metabolic challenge for the mother, and involves a compensatory response of the pancreatic beta-cell to maintain normoglycemia. However, although pancreatic alpha-cells play a key ...
Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase [0.03%]
血管内皮衰老相关分泌表型(SASP)受Makorin-1泛素E3连接酶调控
Sivareddy Kotla,Nhat-Tu Le,Hang Thi Vu et al.
Sivareddy Kotla et al.
Background: Disturbed flow (d-flow)-induced senescence and activation of endothelial cells (ECs) have been suggested to have critical roles in promoting atherosclerosis. Telomeric repeat-binding factor 2 (TERF2)-interacti...
Assessing causality between childhood adiposity and early puberty: A bidirectional Mendelian randomization and longitudinal study [0.03%]
儿童肥胖与青春期提前之间因果关系的评估：双向孟德尔随机化和纵向研究
Yang-Ching Chen,Hsien-Yu Fan,Chen Yang et al.
Yang-Ching Chen et al.
Aims: Obesity and early puberty have been reported to be mutually causative. We investigated the causal relationship between adiposity and early puberty by performing bidirectional Mendelian randomization (MR) and longitu...
Will medications that mimic gut hormones or target their receptors eventually replace bariatric surgery? [0.03%]
模拟肠激素或靶向其受体的药物最终会取代代谢手术吗？
Alexander Kokkinos,Dimitrios Tsilingiris,Carel W le Roux et al.
Alexander Kokkinos et al.
Bariatric surgery is currently the most effective therapeutic modality through which sustained beneficial effects on weight loss and metabolic improvement are achieved. During recent years, indications for bariatric surgery have been expand...
Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length [0.03%]
胎盘蛋白酶PAPP-A和PAPP-A2、它们水解的结合蛋白（IGFBP-4和-5）以及IGF-I和IGF-II：脐带血中的水平与出生体重和身长的关系
Bridget DiPrisco,Ajay Kumar,Bhanu Kalra et al.
Bridget DiPrisco et al.
Background: A newborn's birth weight for gestational age provides important insights into his or her fetal growth and well-being. While the underlying mechanisms regulating fetal growth remain to be fully elucidated, the ...
Transgenic expression of the positive selected human GLUD2 gene improves in vivo glucose homeostasis by regulating basic insulin secretion [0.03%]
正向选择的人GLUD2转基因表达通过调节基础胰岛素分泌来改善体内血糖稳态
Zoe Petraki,Stavros Droubogiannis,Konstantina Mylonaki et al.
Zoe Petraki et al.
Glutamate dehydrogenase 1 (GDH1) contributes to glucose-stimulated insulin secretion in murine β-cells, but not to basic insulin release. The implications of these findings for human biology are unclear as humans have two GDH-specific enzy...
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection [0.03%]
代谢调节因子小异二聚体伴侣促进HCV感染诱导的糖脂稳态异常
Jizheng Chen,Yue Zhou,Yuan Zhuang et al.
Jizheng Chen et al.
Background: Chronic hepatitis C virus (HCV) infection can predispose the host to metabolic abnormalities. The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) has been identified as a key transcriptional reg...
Old and new tools to study human brain physiology: Current state, future directions and implications for metabolic regulation [0.03%]
研究人类大脑生理的旧有和新的工具：现状、未来展望及其对代谢调控的意义
Olivia M Farr,Christos S Mantzoros
Olivia M Farr
Evidence mapping of recommendations on diagnosis and therapeutic strategies for diabetes foot: an international review of 22 guidelines [0.03%]
关于糖尿病足诊疗策略的国际指南证据地图：对22个指南的回顾分析
Yue Sun,Ya Gao,Ji Chen et al.
Yue Sun et al.
To systematically review clinical practice guidelines (CPGs) on diabetes foot and assess the consistency of recommendations, quality of CPGs and to present an evidence-map for explicating research trends and gaps. We performed a literature ...