Interleukin-1α leads to growth hormone deficiency in adamantinomatous craniopharyngioma by targeting pericytes: implication in pituitary fibrosis [0.03%]
白细胞介素-1α通过靶向周细胞导致颅咽管瘤生长激素缺乏：垂体纤维化的意义
Jian Mao,Binghui Qiu,Fen Mei et al.
Jian Mao et al.
Background: The incidence of growth hormone deficiency (GHD) in adamantinomatous craniopharyngioma (aCP) is significantly higher than in other sellar region tumors, but the possible mechanism is still elusive. A high leve...
Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance [0.03%]
参与MC4受体转运和能量平衡调控的下丘脑C2结构域蛋白
Chaitanya K Gavini,Tyler M Cook,David J Rademacher et al.
Chaitanya K Gavini et al.
Objective: Rates of overweight and obesity epidemic have risen significantly in the past few decades, and 34% of adults and 15-20% of children and adolescents in the United States are now obese. Melanocortin receptor 4 (M...
Preadipocyte factor 1 regulates adipose tissue browning via TNF-α-converting enzyme-mediated cleavage [0.03%]
preadipocyte因子1通过TNF - α转化酶介导的切割调节脂肪组织褐变
Marie Rhee,Ji-Won Kim,Min-Woo Lee et al.
Marie Rhee et al.
Background: Increasing adaptive thermogenesis in adipose tissue may be a potential therapeutic target for overcoming obesity and obesity-related disorders. Preadipocyte factor 1 (Pref-1), a preadipocyte secreted protein, ...
Traumatic brain injury (TBI) in collision sports: Possible mechanisms of transformation into chronic traumatic encephalopathy (CTE) [0.03%]
碰撞运动中的创伤性脑损伤（TBI）及其可能转变为慢性创伤性脑病（CTE）的机制研究
Theodore B VanItallie
Theodore B VanItallie
Traumatic brain injury (TBI) is a leading cause of death and disability, contributing to ~30% of all injury-related deaths in the US. TBI occurs when a force transmitted to the head causes neuropathologic damage and impairment of brain func...
Urban environment and psychiatric disorders: a review of the neuroscience and biology [0.03%]
城市环境与精神病障碍：神经学和生物学综述
Jorge Alberto Costa E Silva,Ricardo E Steffen
Jorge Alberto Costa E Silva
Most of the world's population now lives in cities. While living in cities have both health risks and benefits, mental health has been usually considered to be negatively affected by urbanicity. While mental health disorders have complex et...
Environment and obesity [0.03%]
环境与肥胖
Stylianos Nicolaidis
Stylianos Nicolaidis
The aim of this review was to identify and, particularly, to classify all the numerous environmental factors that play a significant role in the environment-dependent body weight dysregulation. The main environmental obesogenic factors are ...
Epigenetic impact of the social and physical environment on brain and body [0.03%]
社会和物理环境对脑和身体表观遗传的影响
Bruce S McEwen,Karen Bulloch
Bruce S McEwen
Modern biomedical scientists are often trapped in silos of knowledge and practice, such as those who study brain structure, function and behavior, on the one hand, and body systems and disorders, on the other. Scientists and physicians in e...
James P O&#x;Callaghan,Diane B Miller
James P O&#x;Callaghan
Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neu...
Johanne Tremblay,Pavel Hamet
Johanne Tremblay
Diabetes mellitus (DM) is a heterogeneous group of disorders characterized by persistent hyperglycemia. Its two most common forms are type 1 diabetes (T1D) and type 2 diabetes (T2D), for which genetic and environmental risk factors act in s...
Madeleine Tremblay-Servier,Johanne Tremblay,Theodore B VanItallie
Madeleine Tremblay-Servier